|AHFS/Drugs.com||International Drug Names|
|By mouth, topical|
|Elimination half-life||~3 h|
|Excretion||50% urine, 36% feces|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||281.234 g·mol−1|
|3D model (JSmol)|
|Melting point||124 to 125 °C (255 to 257 °F) resolidification and remelting at 134°C to 136°C|
|Solubility in water||Practically insoluble in water; soluble in ethanol, chloroform and diethyl ether mg/mL (20 °C)|
Flufenamic acid (FFA) is a member of the anthranilic acid derivatives (or fenamate) class of nonsteroidal anti-inflammatory drugs (NSAIDs).:718 Like other members of the class, it is a cyclooxygenase (COX) inhibitor, preventing the formation of prostaglandins. FFA is known to bind to and reduce the activity of prostaglandin F synthase and activate TRPC6.
It is not widely used in humans as it has a high rate (30–60%) of gastrointestinal side effects.:310 It is generally not available in the US. It is available in some Asian and European countries as a generic drug.
Although flufenamic acid was at one time informally referred to as "Fluffy" (see history cache), this pet name could also refer to flufenoxine.
- Whitehouse MW (2005). "Drugs to treat inflammation: a historical introduction". Current Medicinal Chemistry. 12 (25): 2931–42. doi:10.2174/092986705774462879. ISBN 9781608052073. PMID 16378496.
- NIH LiverTox Database Mefenamic Acid Last updated June 23, 2015. Page accessed July 3, 2015. Quote: "(fenamates generally not available in the United States, such as tolfenamic acid and flufenamic acid)"
- "Chemical–Gene Interaction Query: Flufenamic Acid (Homo sapiens)". Comparative Toxicogenomics Database. North Carolina State University. Retrieved 4 July 2015.
- Aronson JK (2009). Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs. Elsevier. ISBN 978-0-08-093294-1.
- "International listings for flufenamic acid". Drugs.com. Retrieved 3 July 2015.
|Pyrazolones / |
|Acetic acid derivatives|
and related substances
|Propionic acid derivatives|