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Combination of
IbuprofenNonsteroidal anti-inflammatory drug
Clinical data
Trade namesCombiflam, Advil Dual Action, Ibupane
License data
Routes of
By mouth
ATC code
  • None
Legal status
Legal status
  • AU: S3 (Pharmacist only) / S2[1]
  • US: OTC
CAS Number
  • 462631-86-3

Ibuprofen/paracetamol, sold under the brand name Combiflam among others, is a fixed-dose combination of the two medications, ibuprofen, and paracetamol (acetaminophen).[2] It is available in India,[2] the United States,[3][4] and Australia.[1] It may be used for fever, headache, muscle pain and menstrual cramps. Ibuprofen belongs to nonsteroidal anti-inflammatory drug (NSAID) class of drugs.

There is evidence that paracetamol combined with an NSAID provides pain relief better than either drug used alone.[5][6]

Adverse effects


  1. ^ a b c "Ibupane" (PDF). TGA eBS.
  2. ^ a b "Combiflam". drugs.com. Retrieved 5 February 2015.
  3. ^ "Advil Dual Action: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 28 February 2020.
  4. ^ "FDA approves GSK's Advil Dual Action with Acetaminophen for over-the-counter use in the United States" (Press release). GSK Consumer Healthcare. 28 February 2020. Retrieved 28 February 2020 – via PR Newswire.
  5. ^ Ong CK, Seymour RA, Lirk P, Merry AF (April 2010). "Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain". Anesthesia and Analgesia. 110 (4): 1170–9. doi:10.1213/ANE.0b013e3181cf9281. PMID 20142348. S2CID 7948680.
  6. ^ Moore RA, Derry C (January 2013). "Efficacy of OTC analgesics". International Journal of Clinical Practice. Supplement. 67 (178): 21–5. doi:10.1111/ijcp.12054. PMID 23163544. S2CID 205184492.

External links