Fenoprofen

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Fenoprofen
Fenoprofen2DACS.svg
Fenoprofen-3D-balls.png
Names
Trade namesNalfon
  • 2-(3-phenoxyphenyl)propanoic acid
Clinical data
Pregnancy
category
  • US: D (Evidence of risk)
  • C
Routes of
use
By mouth
External links
AHFS/Drugs.comMonograph
MedlinePlusa681026
Legal
Legal status
Pharmacokinetics
MetabolismMajor urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide.
Elimination half-life3 hours
ExcretionRenal (~90%)
Chemical and physical data
FormulaC15H14O3
Molar mass242.274 g·mol−1
3D model (JSmol)
  • O=C(O)C(c2cc(Oc1ccccc1)ccc2)C
  • InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17) checkY
  • Key:RDJGLLICXDHJDY-UHFFFAOYSA-N checkY
  (verify)

Fenoprofen is a nonsteroidal anti-inflammatory drug (NSAID).[1] Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the US as Nalfon.

Contraindications

History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Side effects

In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.[2][3] They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.[2][3]

Interactions

Laboratory test

False elevation in free and total serum T3 as measured by Amerlex-M kit.

Pharmacology

Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase (COX-2 inhibitor) activity and prostaglandin synthesis.

Society and culture

Cost

The cost of this medication in the U.S. for $290 (USD) for 90 capsules (400 mg) [4]

Brand names

References

  1. "Fenoprofen - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 30 March 2021.
  2. 2.0 2.1 "FDA Warns that Using a Type of Pain and Fever Medication in Second Half of Pregnancy Could Lead to Complications". U.S. Food and Drug Administration (FDA) (Press release). 15 October 2020. Retrieved 15 October 2020. This article incorporates text from this source, which is in the public domain.
  3. 3.0 3.1 "NSAIDs may cause rare kidney problems in unborn babies". U.S. Food and Drug Administration. 21 July 2017. Retrieved 15 October 2020. This article incorporates text from this source, which is in the public domain.
  4. "Fenoprofen Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 30 March 2021.

External links

Identifiers: