Portal:Medicine

The Medicine Portal

The color fresco Care of The Sick by Domenico di Bartolo, 1441–1442, depicting the Santa Maria della Scala hospital in Siena, Italy

Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others.

Medicine has been practiced since prehistoric times, during most of which it was an art (an area of skill and knowledge) frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, or an ancient philosopher and physician would apply bloodletting according to the theories of humorism. In recent centuries, since the advent of modern science, most medicine has become a combination of art and science (both basic and applied, under the umbrella of medical science). While stitching technique for sutures is an art learned through practice, the knowledge of what happens at the cellular and molecular level in the tissues being stitched arises through science.

Prescientific forms of medicine are now known as traditional medicine or folk medicine, which remains commonly used in the absence of scientific medicine, and are thus called alternative medicine. Alternative treatments outside of scientific medicine having safety and efficacy concerns are termed quackery. (Full article...)

Featured articles -

Featured articles are displayed here, which represent some of the best content on English Wikipedia.

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  Bone marrow aspirate showing acute myeloid leukemia, arrows indicate Auer rods

  
  Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. Symptoms may include feeling tired, shortness of breath, easy bruising and bleeding, and increased risk of infection. Occasionally, spread may occur to the brain, skin, or gums. As an acute leukemia, AML progresses rapidly, and is typically fatal within weeks or months if left untreated.
  
  
  Risk factors include smoking, previous chemotherapy or radiation therapy, myelodysplastic syndrome, and exposure to the chemical benzene. The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. Diagnosis is generally based on bone marrow aspiration and specific blood tests. AML has several subtypes for which treatments and outcomes may vary. (Full article...)
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  Testing for ketone bodies in urine

  
  
  The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used mainly to treat hard-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates.
  
  Normally carbohydrates in food are converted into glucose, which is then transported around the body and is important in fueling brain function. But if little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies, the latter passing into the brain and replacing glucose as an energy source. An elevated level of ketone bodies in the blood (a state called ketosis) eventually lowers the frequency of epileptic seizures. Around half of children and young people with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists after discontinuing the diet. Some evidence shows that adults with epilepsy may benefit from the diet and that a less strict regimen, such as a modified Atkins diet, is similarly effective. Side effects may include constipation, high cholesterol, growth slowing, acidosis, and kidney stones. (Full article...)
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  A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea.
  Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898, more than 9,000 virus species have been described in detail of the millions of types of viruses in the environment. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. The study of viruses is known as virology, a subspeciality of microbiology.
  
  When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent particles, or virions, consisting of (i) the genetic material, i.e., long molecules of DNA or RNA that encode the structure of the proteins by which the virus acts; (ii) a protein coat, the capsid, which surrounds and protects the genetic material; and in some cases (iii) an outside envelope of lipids. The shapes of these virus particles range from simple helical and icosahedral forms to more complex structures. Most virus species have virions too small to be seen with an optical microscope and are one-hundredth the size of most bacteria. (Full article...)
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  Amphetamine (contracted from alpha-methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. Amphetamine was discovered in 1887 and exists as two enantiomers: levoamphetamine and dextroamphetamine. Amphetamine properly refers to a specific chemical, the racemic free base, which is equal parts of the two enantiomers in their pure amine forms. The term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an athletic performance enhancer and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant. It is a prescription drug in many countries, and unauthorized possession and distribution of amphetamine are often tightly controlled due to the significant health risks associated with recreational use.
  
  The first amphetamine pharmaceutical was Benzedrine, a brand which was used to treat a variety of conditions. Currently, pharmaceutical amphetamine is prescribed as racemic amphetamine, Adderall, dextroamphetamine, or the inactive prodrug lisdexamfetamine. Amphetamine increases monoamine and excitatory neurotransmission in the brain, with its most pronounced effects targeting the norepinephrine and dopamine neurotransmitter systems. (Full article...)
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  A serpin (white) with its 'reactive centre loop' (blue) bound to a protease (grey). Once the protease attempts catalysis it will be irreversibly inhibited. (PDB: 1K9O​)

  
  Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life. The acronym serpin was originally coined because the first serpins to be identified act on chymotrypsin-like serine proteases (serine protease inhibitors). They are notable for their unusual mechanism of action, in which they irreversibly inhibit their target protease by undergoing a large conformational change to disrupt its active site. This contrasts with the more common competitive mechanism for protease inhibitors that bind to and block access to the protease active site.
  
  Protease inhibition by serpins controls an array of biological processes, including coagulation and inflammation, and consequently these proteins are the target of medical research. Their unique conformational change also makes them of interest to the structural biology and protein folding research communities. The conformational-change mechanism confers certain advantages, but it also has drawbacks: serpins are vulnerable to mutations that can result in serpinopathies such as protein misfolding and the formation of inactive long-chain polymers. Serpin polymerisation not only reduces the amount of active inhibitor, but also leads to accumulation of the polymers, causing cell death and organ failure. (Full article...)
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  Photomicrograph of Giemsa-stained Trypanosoma cruzi trypomastigotes in human blood.

  
  Chagas disease, also known as American trypanosomiasis or Chagas-Mazza disease, is a tropical parasitic disease caused by Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or swelling at the site of the bite. After four to eight weeks, untreated individuals enter the chronic phase of disease, which in most cases does not result in further symptoms. Up to 45% of people with chronic infection develop heart disease 10–30 years after the initial illness, which can lead to heart failure. Digestive complications, including an enlarged esophagus or an enlarged colon, may also occur in up to 21% of people, and up to 10% of people may experience nerve damage.
  T. cruzi is commonly spread to humans and other mammals by the bite of a kissing bug. The disease may also be spread through blood transfusion, organ transplantation, eating food contaminated with the parasites, and vertical transmission (from a mother to her baby). Diagnosis of early disease is by finding the parasite in the blood using a microscope or detecting its DNA by polymerase chain reaction. Chronic disease is diagnosed by finding antibodies for T. cruzi in the blood. It affects more than 150 types of animals. (Full article...)
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  Meninges of the central nervous system: dura mater, arachnoid mater, and pia mater.

  
  Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The most common symptoms are fever, headache, and neck stiffness. Other symptoms include confusion or altered consciousness, vomiting, and an inability to tolerate light or loud noises. Young children often exhibit only nonspecific symptoms, such as irritability, drowsiness, or poor feeding. If a rash is present, it may indicate a particular cause of meningitis; for instance, meningitis caused by meningococcal bacteria may be accompanied by a characteristic rash.
  
  The inflammation may be caused by infection with viruses, bacteria or other microorganisms, and less commonly by certain drugs. Meningitis can be life-threatening because of the inflammation's proximity to the brain and spinal cord; therefore, the condition is classified as a medical emergency. A lumbar puncture, in which a needle is inserted into the spinal canal to collect a sample of cerebrospinal fluid (CSF), can diagnose or exclude meningitis. (Full article...)
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  Immunohistochemical staining of H. pylori (brown) from a gastric biopsy

  
  Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, microaerophilic, spiral (helical) bacterium usually found in the stomach. Its helical shape (from which the genus name, helicobacter, derives) is thought to have evolved in order to penetrate the mucoid lining of the stomach and thereby establish infection. The bacterium was first identified in 1982 by Australian doctors Barry Marshall and Robin Warren. H. pylori has been associated with lymphomas of the mucosa-associated lymphoid tissue in the stomach, esophagus, colon, rectum, or tissues around the eye (termed extranodal marginal zone B-cell lymphoma of the cited organ), and of lymphoid tissue in the stomach (termed diffuse large B-cell lymphoma).
  
  H. pylori infection usually has no symptoms but sometimes causes gastritis (stomach inflammation) or ulcers of the stomach or first part of the small intestine. The infection is also associated with the development of certain cancers. Many investigators have suggested that H. pylori causes or prevents a wide range of other diseases, but many of these relationships remain controversial. (Full article...)
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  Illustration of a SARS-CoV-2 virion

  
  
  A virus is a tiny infectious agent that reproduces inside the cells of living hosts. When infected, the host cell is forced to rapidly produce thousands of identical copies of the original virus. Unlike most living things, viruses do not have cells that divide; new viruses assemble in the infected host cell. But unlike simpler infectious agents like prions, they contain genes, which allow them to mutate and evolve. Over 4,800 species of viruses have been described in detail out of the millions in the environment. Their origin is unclear: some may have evolved from plasmids—pieces of DNA that can move between cells—while others may have evolved from bacteria.
  
  Viruses are made of either two or three parts. All include genes. These genes contain the encoded biological information of the virus and are built from either DNA or RNA. All viruses are also covered with a protein coat to protect the genes. Some viruses may also have an envelope of fat-like substance that covers the protein coat, and makes them vulnerable to soap. A virus with this "viral envelope" uses it—along with specific receptors—to enter a new host cell. Viruses vary in shape from the simple helical and icosahedral to more complex structures. Viruses range in size from 20 to 300 nanometres; it would take 33,000 to 500,000 of them, side by side, to stretch to 1 centimetre (0.4 in). (Full article...)
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  A man with a smaller right leg due to poliomyelitis

  
  Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. In about 0.5 percent of cases, it moves from the gut to affect the central nervous system, and there is muscle weakness resulting in a flaccid paralysis. This can occur over a few hours to a few days. The weakness most often involves the legs, but may less commonly involve the muscles of the head, neck, and diaphragm. Many people fully recover. In those with muscle weakness, about 2 to 5 percent of children and 15 to 30 percent of adults die. Up to 70 percent of those infected have no symptoms. Another 25 percent of people have minor symptoms such as fever and a sore throat, and up to 5 percent have headache, neck stiffness, and pains in the arms and legs. These people are usually back to normal within one or two weeks. Years after recovery, post-polio syndrome may occur, with a slow development of muscle weakness similar to that which the person had during the initial infection.
  
  Poliovirus is usually spread from person to person through infected fecal matter entering the mouth. It may also be spread by food or water containing human feces and less commonly from infected saliva. Those who are infected may spread the disease for up to six weeks even if no symptoms are present. The disease may be diagnosed by finding the virus in the feces or detecting antibodies against it in the blood. The disease occurs naturally only in humans. (Full article...)
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  The 1966 New York City smog was a major air-pollution episode and environmental disaster, coinciding with that year's Thanksgiving holiday weekend. Smog covered the city and its surrounding area from November 23 to 26, filling the city's air with damaging levels of several toxic pollutants. It was the third major smog in New York City, following events of similar scale in 1953 and 1963.
  
  On November 23, a large mass of stagnant air over the East Coast trapped pollutants in the city's air. For three days, New York City was engulfed in dangerously high levels of carbon monoxide, sulfur dioxide, smoke, and haze. Pockets of air pollution pervaded the greater New York metropolitan area, including parts of New Jersey and Connecticut. By November 25, the smog became severe enough that regional leaders announced a "first-stage alert". During the alert, leaders of local and state governments asked residents and industry to take voluntary steps to minimize emissions. Health officials advised people with respiratory or heart conditions to remain indoors. The city shut off garbage incinerators, requiring massive hauling of garbage to landfills. A cold front dispersed the smog on November 26, and the alert ended. (Full article...)
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  White in 1989

  
  Ryan Wayne White (December 6, 1971 – April 8, 1990) was an American teenager from Kokomo, Indiana, who became a national poster child for HIV/AIDS in the United States after failing to be readmitted to school following a diagnosis of AIDS. As a hemophiliac, he became infected with HIV from a contaminated factor VIII blood treatment and, when diagnosed in December 1984, was given six months to live. Doctors said he posed no risk to other students, as AIDS is not an airborne disease and spreads solely through bodily fluids, but AIDS was poorly understood by the general public at the time. When White tried to return to school, many parents and teachers in Howard County rallied against his attendance due to concerns of the disease spreading through bodily fluid transfer. A lengthy administrative appeal process ensued, and news of the conflict turned Ryan into a popular celebrity and advocate for AIDS research and public education. Surprising his doctors, Ryan White lived five years longer than predicted. He died on April 8, 1990, one month before his high school graduation.
  
  During the 1980s, AIDS was largely stigmatized as an illness impacting the gay community, because it was first diagnosed among gay men. In the USA, that perception shifted with the media focus placed on Ryan and other prominent straight HIV-infected people such as Magic Johnson, Arthur Ashe and the Ray brothers, although these cases were often framed as "innocent" against gay men who were seen as "guilty" subjects. The U.S. Congress passed a major piece of AIDS legislation, the Ryan White CARE Act, shortly after White's death, which was signed into law by President George H. W. Bush in August 1990. The act has been reauthorized twice; Ryan White programs are the largest provider of services for people living with HIV/AIDS in the United States. (Full article...)
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  Buruli ulcer lesions. Top-left, an early ulcer. Top-right, a larger ulcer across the lower arm and wrist. Bottom, a large ulcer on the thigh.

  
  Buruli ulcer (/bəˈruːli/) is an infectious disease characterized by the development of painless open wounds. The disease is limited to certain areas of the world, most cases occurring in Sub-Saharan Africa and Australia. The first sign of infection is a small painless nodule or area of swelling, typically on the arms or legs. The nodule grows larger over days to weeks, eventually forming an open ulcer. Deep ulcers can cause scarring of muscles and tendons, resulting in permanent disability.
  
  Buruli ulcer is caused by skin infection with bacteria called Mycobacterium ulcerans. The mechanism by which M. ulcerans is transmitted from the environment to humans is not known, but may involve the bite of an aquatic insect or the infection of open wounds. Once in the skin, M. ulcerans grows and releases the toxin mycolactone, which blocks the normal function of cells, resulting in tissue death and immune suppression at the site of the ulcer. (Full article...)
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  Race Against Time: Searching for Hope in AIDS-Ravaged Africa is a non-fiction book written by Stephen Lewis for the Massey Lectures. Lewis wrote it in early to mid-2005 and House of Anansi Press released it as the lecture series began in October 2005. Each of the book's chapters was delivered as one lecture in a different Canadian city, beginning in Vancouver on October 18 and ending in Toronto on October 28. The speeches were aired on CBC Radio One between November 7 and 11. The author and orator, Stephen Lewis, was at that time the United Nations Special Envoy for HIV/AIDS in Africa and former Canadian ambassador to the United Nations. Although he wrote the book and lectures in his role as a concerned Canadian citizen, his criticism of the United Nations (UN), international organizations, and other diplomats, including naming specific people, was called undiplomatic and led several reviewers to speculate whether he would be removed from his UN position.
  
  In the book and the lectures, Lewis argues that significant changes are required to meet the Millennium Development Goals in Africa by their 2015 deadline. Lewis explains the historical context of Africa since the 1980s, citing a succession of disastrous economic policies by international financial institutions that contributed to, rather than reduced, poverty. He connects the structural adjustment loans, with conditions of limited public spending on health and education infrastructure, to the uncontrolled spread of AIDS and subsequent food shortages as the disease infected much of the working-age population. Lewis also addresses such issues as discrimination against women and primary education for children. To help alleviate problems, he ends with potential solutions which mainly require increased funding by G8 countries to levels beyond what they promise. (Full article...)
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  Thyrotoxic periodic paralysis occurs when the thyroid gland releases excessive amounts of thyroxine (thyroid hormone).

  
  Thyrotoxic periodic paralysis (TPP) is a condition featuring attacks of muscle weakness in the presence of hyperthyroidism (overactivity of the thyroid gland). Hypokalemia (a decreased potassium level in the blood) is usually present during attacks. The condition may be life-threatening if weakness of the breathing muscles leads to respiratory failure, or if the low potassium levels lead to cardiac arrhythmias (irregularities in the heart rate). If untreated, it is typically recurrent in nature.
  
  The condition has been linked with genetic mutations in genes that code for certain ion channels that transport electrolytes (sodium and potassium) across cell membranes. The main ones are the L-type calcium channel α1-subunit and potassium inward rectifier 2.6; it is therefore classified as a channelopathy. The abnormality in the channel is thought to lead to shifts of potassium into cells, under conditions of high thyroxine (thyroid hormone) levels, usually with an additional precipitant. (Full article...)

Selected image –

Sequence alignment of 27 H9N2 avian influenza hemagglutinin protein sequences. The top section is colored by residue conservation and the bottom by residue chemical properties. Alignment produced with ClustalW.

Photo credit: Opabinia regalis

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Good articles -

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  Brinkley, c. 1921

  
  John Romulus Brinkley (later John Richard Brinkley; July 8, 1885 – May 26, 1942) was an American quack. He had no properly accredited education as a physician and bought his medical degree from a "diploma mill". Brinkley became known as the "goat-gland doctor" after he achieved national fame, international notoriety and great wealth through the xenotransplantation of goat testicles into humans. Although initially Brinkley promoted this procedure as a means of curing male impotence, he later claimed that the technique was a virtual panacea for a wide range of male ailments. Brinkley operated clinics and hospitals in several states and was able to continue practicing medicine for almost two decades despite his techniques being thoroughly discredited by the broader medical community.
  
  He was also, almost by accident, an advertising and radio pioneer who began the era of Mexican border blaster radio. (Full article...)
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  Herpes zoster blisters on the neck and shoulder

  
  Shingles, also known as zoster or herpes zoster, is a viral disease characterized by a painful skin rash with blisters in a localized area. Typically the rash occurs in a single, wide stripe either on the left or right side of the body or face. Two to four days before the rash occurs there may be tingling or local pain in the area. Otherwise, there are typically few symptoms though some patients may have fever or headache, or feel tired. The rash usually heals within two to four weeks; however, some people develop ongoing nerve pain which can last for months or years, a condition called postherpetic neuralgia (PHN). In those with poor immune function the rash may occur widely. If the rash involves the eye, vision loss may occur.
  
  Shingles and chickenpox are distinct human diseases but are closely related in their life cycles. Both originate from infection of an individual with the varicella zoster virus (VZV). Chickenpox, also called varicella, results from the initial infection with the virus, typically occurring during childhood or adolescence. Once the chickenpox has resolved, the virus can remain inactive (dormant) in human nerve cells for years or decades, after which it may reactivate. Shingles results when the dormant varicella virus is reactivated. Then the virus travels along nerve bodies to nerve endings in the skin, producing blisters. During an outbreak of shingles, exposure to the varicella virus found in shingles blisters can cause chickenpox in someone who has not yet had chickenpox; this initial infection will not trigger shingles, however. How the virus remains dormant in the body or subsequently re-activates is not well understood. (Full article...)
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  Chest X-ray of a pneumonia caused by influenza and Haemophilus influenzae, with patchy consolidations, mainly in the right upper lobe (arrow)

  
  Pneumonia is an inflammatory condition of the lung primarily affecting the small air sacs known as alveoli. Symptoms typically include some combination of productive or dry cough, chest pain, fever, and difficulty breathing. The severity of the condition is variable.
  
  Pneumonia is usually caused by infection with viruses or bacteria, and less commonly by other microorganisms. Identifying the responsible pathogen can be difficult. Diagnosis is often based on symptoms and physical examination. Chest X-rays, blood tests, and culture of the sputum may help confirm the diagnosis. The disease may be classified by where it was acquired, such as community- or hospital-acquired or healthcare-associated pneumonia. (Full article...)
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  Dehydration may be severe in diabetic ketoacidosis, and intravenous fluids are usually needed as part of its treatment.

  
  Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion and occasionally loss of consciousness. A person's breath may develop a specific "fruity" smell. Onset of symptoms is usually rapid. People without a previous diagnosis of diabetes may develop DKA as the first obvious symptom.
  
  DKA happens most often in those with type 1 diabetes but can also occur in those with other types of diabetes under certain circumstances. Triggers may include infection, not taking insulin correctly, stroke and certain medications such as steroids. DKA results from a shortage of insulin; in response, the body switches to burning fatty acids, which produces acidic ketone bodies. DKA is typically diagnosed when testing finds high blood sugar, low blood pH and ketoacids in either the blood or urine. (Full article...)
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  Sir Victor Ewings Negus, MS, FRCS (6 February 1887 – 15 July 1974) was a British surgeon who specialised in laryngology and also made fundamental contributions to comparative anatomy with his work on the structure and evolution of the larynx. He was born and educated in London, studying at King's College School, then King's College London, followed by King's College Hospital. The final years of his medical training were interrupted by the First World War, during which he served with the Royal Army Medical Corps. After the war, he qualified as a surgeon and studied with laryngologists in France and the USA before resuming his career at King's College Hospital where he became a junior surgeon in 1924.
  
  In the 1920s, Negus worked on aspects of both throat surgery and the anatomy of the larynx, the latter work contributing to his degree of Master of Surgery (1924). His surgical innovations included designs for laryngoscopes, bronchoscopes, oesophagoscopes, an operating table, and tracheotomy equipment. His major publications were The Mechanism of the Larynx (1929) and his work on the clinical text Diseases of the Nose and Throat, starting with the fourth edition of 1937. Negus was also awarded several lectureships and published many medical papers and other works on comparative anatomy and laryngology. He became a senior surgeon at King's College Hospital in 1940 and a consulting surgeon in 1946. (Full article...)
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  Soldiers sick with Spanish flu at a hospital ward, Camp Funston, Fort Riley, Kansas

  
  Spanish flu, also known as the Great Influenza epidemic or the 1918 influenza pandemic, was an exceptionally deadly global influenza pandemic caused by the H1N1 influenza A virus. The earliest documented case was March 1918 in Kansas, United States, with further cases recorded in France, Germany and the United Kingdom in April. Two years later, nearly a third of the global population, or an estimated 500 million people, had been infected in four successive waves. Estimates of deaths range from 17 million to 50 million, and possibly as high as 100 million, making it one of the deadliest pandemics in human history.
  
  "Spanish flu" is a misnomer. The pandemic broke out near the end of World War I, when wartime censors suppressed bad news in the belligerent countries to maintain morale, but newspapers freely reported the outbreak in neutral Spain, creating a false impression of Spain as the epicenter. Limited historical epidemiological data make the pandemic's geographic origin indeterminate, with competing hypotheses on the initial spread. (Full article...)
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  An Operation at the Military Hospital, Endell Street - Dr L Garrett, Dr Flora Murray, Dr W Buckley, Francis Dodd, 1920. Imperial War Museum, London.

  
  Endell Street Military Hospital was a First World War military hospital located on Endell Street in Covent Garden, central London. The hospital was substantially staffed by suffragists (women who supported the introduction of votes for women).
  
  The medical pioneers Flora Murray and Louisa Garrett Anderson recruited enough medically trained women to staff an entire hospital in France at the beginning of the war that was in operation from 1914 to 1915. Drawing experience and staff of this hospital, the Endell Street hospital was established in London as a RAMC hospital under the War department in May 1915 by Murray and Anderson. The Endell hospital had 573 beds, allowing for some 26,000 patients to be cared for during the five years it was active. The hospital closed shortly after the end of the war in December 1919. (Full article...)
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  Typical purpura on lower legs and buttocks

  
  Henoch–Schönlein purpura (HSP), also known as IgA vasculitis, is a disease of the skin, mucous membranes, and sometimes other organs that most commonly affects children. In the skin, the disease causes palpable purpura (small, raised areas of bleeding underneath the skin), often with joint pain and abdominal pain. With kidney involvement, there may be a loss of small amounts of blood and protein in the urine (hematuria and proteinuria), but this usually goes unnoticed; in a small proportion of cases, the kidney involvement proceeds to chronic kidney disease. HSP is often preceded by an infection, such as a throat infection.
  
  HSP is a systemic vasculitis (inflammation of blood vessels) and is characterized by deposition of immune complexes containing the antibody immunoglobulin A (IgA); the exact cause for this phenomenon is unknown. In children, it usually resolves within several weeks and requires no treatment apart from symptom control but may relapse in a third of cases and cause irreversible kidney damage in about one in a hundred cases. In adults, the prognosis is different from in children. The average duration of cutaneous lesions is 27.9 months. For many, it tends to be relapsing–remitting over a long period of time, rather than self-limiting and there tend to be more complications. (Full article...)
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  Martha Maria "Mattie" Hughes Cannon (July 1, 1857 – July 10, 1932) was a Utah State Senator, physician, Utah women's rights advocate, suffragist, polygamous wife, and a Welsh-born immigrant to the United States. Her family immigrated to the United States as converts to The Church of Jesus Christ of Latter-day Saints (LDS Church) and traveled West to settle in Utah territory with other Saints. She started working at the age of fourteen. At sixteen she enrolled in the University of Deseret, now called the University of Utah, receiving a Bachelors in Chemistry. From there she attended the University of Michigan and received her MD. She became the fourth of six wives in a polygamous marriage to Angus M. Cannon, a prominent Latter-day Saint leader during the anti-polygamy crusade. Cannon exiled herself to Europe so she wouldn't have to testify against her husband. Upon returning to Utah, Cannon worked as a doctor and fought for women's rights. She helped put women enfranchisement into Utah's constitution when it was granted statehood in 1896. On November 3, 1896 Cannon became the first female State Senator elected in the United States, defeating her own husband, who was also on the ballot. Martha Hughes Cannon was the author of Utah sanitation laws and was a founder and member of Utah's first State Board of Health. (Full article...)
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  Playa de Oro virus (OROV) is a probable species of orthohantavirus found in the rodents Oryzomys couesi and Sigmodon mascotensis in the Mexican state of Colima. The former is thought to be the main host. The sequences of parts of the virus's RNA-based genome have been determined; they differ by 7–10% in amino acid composition and 22–24% in nucleotide composition from closely related viruses.
  
  Playa de Oro virus was identified as a new species in 2008 and is most closely related to Bayou virus, Catacamas virus, Muleshoe virus, and Black Creek Canal virus, found in other species of Oryzomys and Sigmodon. Catacamas virus is found in a different population of Oryzomys couesi, and the presence of different viruses in these two species has been used as an argument for classifying the two populations of the host as separate species. (Full article...)
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  Horace Gilbert Smithy Jr. (July 19, 1914 – October 28, 1948) was an American cardiac surgeon who in 1948 performed the first successful mitral valve repair (mitral valvulotomy) since the 1920s. Smithy's work was complicated because it predated heart-lung machines or open heart surgery. Though his procedure did not become a definitive treatment for valvular heart disease, he introduced the technique of injecting novocaine into the heart to avoid arrhythmias during surgery, and he showed that it was feasible to access and operate on the heart's valves.
  
  A graduate of the University of Virginia School of Medicine, Smithy completed a surgical residency in Charleston, South Carolina, and then practiced surgery at Roper Hospital in Charleston. He also began working with a colleague in a dog laboratory to devise a valvulotomy (surgical treatment for diseased heart valves). Smithy's interest in heart valve dysfunction was also personal; he suffered from narrowing of the aortic valve related to rheumatic heart disease. (Full article...)
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  2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a polychlorinated dibenzo-p-dioxin (sometimes shortened, though inaccurately, to simply 'dioxin') with the chemical formula C₁₂H₄Cl₄O₂. Pure TCDD is a colorless solid with no distinguishable odor at room temperature. It is usually formed as an unwanted product in burning processes of organic materials or as a side product in organic synthesis.
  
  TCDD is the most potent compound (congener) of its series (polychlorinated dibenzodioxins, known as PCDDs or simply dioxins) and became known as a contaminant in Agent Orange, a herbicide used in the Vietnam War. TCDD was released into the environment in the Seveso disaster. It is a persistent organic pollutant. (Full article...)
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  David Albala c. 1939

  
  David Albala (born David Kovu; 1 September 1886 – 4 April 1942) was a Serbian military officer, physician, diplomat and Jewish community leader.
  
  In 1905, Albala enrolled at the University of Vienna to study medicine. He returned to Serbia following the outbreak of the Balkan Wars in 1912 and enlisted in the Royal Serbian Army. In late 1915, Albala took part in the Royal Serbian Army's arduous winter retreat to the Greek island of Corfu, during which he contracted typhoid, and was subsequently evacuated to North Africa. Upon recovering, Albala returned to Corfu, where he proposed to Serbian Prime Minister Nikola Pašić that he travel to United States to lobby on Serbia's behalf. Pašić agreed to the proposal and Albala embarked on a tour of the United States giving speeches, raising bonds and soliciting loans. On 27 December 1917, the head of the Serbian delegation to the United States, Milenko Vesnić, sent Albala a letter in which he affirmed Serbia's support for the creation of a Jewish state in Palestine. Serbia thus became the first country to endorse the Balfour Declaration. (Full article...)
• 

  Tobias Watkins (December 12, 1780 – November 14, 1855) was an American physician, editor, writer, educator, and political appointee in the Baltimore-Washington, D.C. area. He played leading roles in early American literary institutions such as The Portico and the Delphian Club and in early American medical institutions such as The Baltimore Medical and Physical Recorder and The Maryland State Medical Society. He served as an assistant surgeon general in the United States Army, secretary to the Spanish Commission following the Adams–Onís Treaty, Fourth Auditor of the United States Treasury, and an education leader in the Washington, D.C. area. The Supreme Court decisions connected to his high-profile conviction for embezzlement are part of the history of original habeas as it relates to federal review of federal custody in the US. (Full article...)
• 

  

  Three-quarter facial view, first-generation patient showing slight prognathism and low set ears

  
  Noonan syndrome with multiple lentigines (NSML) which is part of a group called Ras/MAPK pathway syndromes, is a rare autosomal dominant, multisystem disease caused by a mutation in the protein tyrosine phosphatase, non-receptor type 11 gene (PTPN11). The disease is a complex of features, mostly involving the skin, skeletal and cardiovascular systems, which may or may not be present in all patients. The nature of how the mutation causes each of the condition's symptoms is not well known; however, research is ongoing. It is a RASopathy.
  
  Noonan syndrome with multiple lentigines is caused by a different missense mutation of the same gene. Noonan syndrome is fairly common (1:1,000 to 1:2,500 live births), and neurofibromatosis 1 (which was once thought to be related to NSML) is also common (1:3500); however, no epidemiological data exists for NSML. (Full article...)

Did you know –

• ... that lagophthalmos is the inability to close the eyelids?

• ... that Beck's triad of arterial hypotension, raised jugular venous pressure and muffled heart sounds is pathognomonic of cardiac tamponade?
• ... that dark chocolate contains the highest antioxidant content of any food? It contains phosphorus, magnesium, iron and potassium. In addition, dark chocolate can lower blood pressure.

General images –

The following are images from various Medicine-related articles on Wikipedia.

• 

  Mexico City epidemic of 1737, with elites calling on the Virgin of Guadalupe (from History of medicine)

• 

  The plinthios brochos as described by Greek physician Heraklas, a sling for binding a fractured jaw. These writings were preserved in one of Oribasius' collections. (from History of medicine)

• 

  American Civil War hospital at Gettysburg, 1863 (from History of medicine)

• 

  Guy's Hospital in 1820 (from History of medicine)

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  18th-century medical remedies collected by a British Gentry family (from History of medicine)

• 

  A cochlear implant is a common kind of neural prosthesis, a device replacing part of the human nervous system. (from History of medicine)

• 

  Infographic showing how healthcare data flows within the billing process (from Medical billing)

• 

  American combat surgery during the Pacific War, 1943. Major wars showed the need for effective hygiene and medical treatment. (from History of medicine)

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  Andreas Vesalius's 1543 De humani corporis fabrica contained intricately detailed drawings of human dissections, often in allegorical poses. (from History of medicine)

• 

  Sketch representing Muslim physician Muhammad ibn Zakariya al-Razi (from History of medicine)

• 

  Botánicas such as this one in Jamaica Plain, Boston, cater to the Latino community and sell folk medicine alongside statues of saints, candles decorated with prayers, lucky bamboo, and other items. (from Traditional medicine)

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  Smallpox vaccination in Niger, 1969. A decade later, this was the first infectious disease to be eradicated. (from History of medicine)

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  "More Doctors Smoke Camels than Any Other Cigarette" advertisement for Camel cigarettes in the 1940s (from Medical ethics)

• 

  Life Expectancy of the total population at birth among several OECD member nations. Data source: OECD's iLibrary (from Health insurance)

• 

  Curandera performing a limpieza in Cuenca, Ecuador (from Traditional medicine)

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  healthcare expenditure in Japan by age group (from Health insurance)

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  Florence Nightingale triggered the professionalization of nursing. Photograph c. 1860 (from History of medicine)

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  Hospital train "Therapist Matvei Mudrov" in Khabarovsk, Russia (from Health care)

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  Global concentrations of health care resources, as depicted by the number of physicians per 10,000 individuals, by country. Data is sourced from a World Health Statistics 2010, a WHO report. (from Health care)

• 

  Medical recipe concerning poisoning. Terracotta tablet, from Nippur, Iraq, 18th century BCE. Ancient Orient Museum, Istanbul (from History of medicine)

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  The numbers of Americans lacking health insurance and the uninsured rate from 1987 to 2008 (from Health insurance)

• 

  The Quaker-run York Retreat, founded in 1796, gained international prominence as a centre for moral treatment and a model of asylum reform following the publication of Samuel Tuke's Description of the Retreat (1813). (from History of medicine)

• 

  Depiction of smallpox in Franciscan Bernardino de Sahagún's history of the conquest of Mexico, Book XII of the Florentine Codex, from the defeated Aztecs' point of view (from History of medicine)

• 

  World map of universal healthcare.
  
  

    Countries with free and universal health care

  (from Health insurance)
• 

  The Edwin Smith Surgical Papyrus, written in the 17th century BCE, contains the earliest recorded reference to the brain. New York Academy of Medicine. (from History of medicine)

• 

  "Diagram of the causes of mortality in the army in the East" by Florence Nightingale. (from History of medicine)

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  AMA Code of Medical Ethics (from Medical ethics)

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  The oldest Polish Collegium Medicum at Jagiellonian University founded in 1364 (from History of medicine)

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  Health Expenditure per capita (in PPP-adjusted US$) among several OECD member nations. Data source: OECD's iLibrary (from Health insurance)

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  Patient, Surrey County Lunatic Asylum, c. 1850–58. The asylum population in England and Wales rose from 1,027 in 1827 to 74,004 in 1900. (from History of medicine)

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  Traditional medicine in a market in Antananarivo, Madagascar (from Traditional medicine)

• 

  The Hippocratic Corpus
  A collection of early medical works may be associated with Hippocrates (from History of medicine)

• 

  The National Hospital for Neurology and Neurosurgery in London, United Kingdom is a specialist neurological hospital. (from Health care)

• 

  Sometimes traditional medicines include parts of endangered species, such as the slow loris in Southeast Asia. (from Traditional medicine)

• 

  Replica of Antonie van Leeuwenhoek's microscope of the 1670s (from History of medicine)

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  Monumental stone relief of a fish-garbed figure from the Temple of Ninurta in the Assyrian city of Kalhu, believed by some experts to be a representation of an āšipu, or exorcist-priest, who functioned as a kind of healer and primitive doctor (from History of medicine)

• 

  Primary care may be provided in community health centers. (from Health care)

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  Most countries have seen a tremendous increase in life expectancy since 1945. However, in southern Africa, the HIV epidemic beginning around 1990 has eroded national health. (from History of medicine)

• 

  A 12th-century Byzantine manuscript of the Hippocratic Oath (from Medical ethics)

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  Mandrake (written 'ΜΑΝΔΡΑΓΟΡΑ' in Greek capitals). Naples Dioscurides, 7th century (from History of medicine)

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  Louis Pasteur experimenting on bacteria, c. 1870 (from History of medicine)

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  Ayurvedic herbal medicines (from History of medicine)

• 

  Taoist symbol of Yin and Yang (from Medical ethics)

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  Assorted dried plant and animal parts used in traditional Chinese medicines, clockwise from top left corner: dried Lingzhi (lit. "spirit mushrooms"), ginseng, Luo Han Guo, turtle shell underbelly (plastron), and dried curled snakes (from History of medicine)

• 

  The emergency room is often a frontline venue for the delivery of primary medical care. (from Health care)

More Did you know (auto generated)

• ... that confectionery in the English Renaissance marks the transition of sugar from a medicine to a sweetener?
• ... that Professor Shabir Madhi, who led trials of the Oxford–AstraZeneca COVID-19 vaccine in South Africa, did not originally want to study medicine?
• ... that nephrologist and cellist Leah Lowenstein, an advocate for women in medicine, was the first female dean of a co-educational medical school in the United States?
• ... that German undercover agent Friedrich Salomon Hall's identity was betrayed by the corns on his feet?
• ... that some medicines, such as vancomycin, may require higher doses in critically ill patients, due to augmented renal (kidney) clearance?
• ... that Dorothy Christian Hare was the first woman general physician to be elected a fellow of the Royal College of Physicians?

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