|Main uses||Type 2 diabetes|
|Side effects||Dizziness, diarrhea, bronchitis, low blood sugar|
|Typical dose||60 to 180 mg TID|
|Elimination half-life||1.5 hours|
|Chemical and physical data|
|Molar mass||317.429 g·mol−1|
|3D model (JSmol)|
Nateglinide, sold under the brand name Starlix, is a medication used to treat type 2 diabetes. It is used together with diet and exercise. It is not a first line treatment, though may be added to metformin. It is taken by mouth.
Common side effects include dizziness, diarrhea, bronchitis, and low blood sugar. Use is not recommended in those with significant liver problems. Safety in pregnancy is not clear. It belongs to the meglitinide class and works by stimulating the release of insulin.
Nateglinide was approved for medical use in the United States in 2000 and Europe in 2001. In the United States it costs about 30 USD per month as of 2021. It is not available in the United Kingdom as of 2021.
It is generally take at a dose of 60 to 180 mg half an hour before meals three times per day.
Nateglinide is delivered in 60 mg & 120 mg tablet form.
Nateglinide is contraindicated in patients who:
- have known hypersensitivity to the compound or any ingredient in the formulation.
- are affected with type 1 (namely insulin-dependent) diabetes mellitus.
- are in diabetic ketoacidosis.
Nateglinide lowers blood glucose by stimulating the release of insulin from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the β cells. This depolarizes the β cells and causes voltage-gated calcium channels to open. The resulting calcium influx induces fusion of insulin-containing vesicles with the cell membrane, and insulin secretion occurs.
- BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 742. ISBN 978-0857114105.
- "Nateglinide Monograph for Professionals". Drugs.com. Archived from the original on 2 September 2019. Retrieved 12 November 2021.
- "Starlix". Archived from the original on 12 November 2020. Retrieved 12 November 2021.
- "Nateglinide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 April 2020. Retrieved 12 November 2021.