|Trade names||Relafen, Relifex, Gambaran, others|
|Protein binding||> 99% (active metabolite)|
|Metabolism||Liver, to active metabolite 6-methoxy-2-naphthylacetic acid; 6-MNA|
|Elimination half-life||23 hours (active metabolite)|
|Chemical and physical data|
|Molar mass||228.291 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID), used to treat inflammation in conditions such as osteoarthritis and rheumatoid arthritis. Use is recommended for a short a duration as possible.
Common side effects include abdominal pain, constipation, dizziness, swelling, headache, rash, and ringing in the ears. Other side effects may include kidney problems, heart attacks, gastrointestinal bleeding, high blood pressure, anaphylaxis, and heart failure. Use during the later part of pregnancy may harm the baby. It works by blocking COX-1 and COX-2.
Similar in action to other NSAIDs, Nabumetone is used to treat pain and inflammation.
It is take at a dose of 0.5 to 1 gram once to twice per day.
It has been shown to have a slightly lower risk of gastrointestinal side effects than most other non-selective NSAIDs since it is a non-acidic prodrug which is then metabolized to its active 6MNA (6-methoxy-2-naphthylacetic acid) form.
Side effects include: Bloody or black, tarry stools; change in color, frequency, or amount of urine; chest pain; shortness of breath; coughing up blood; pale stools; numbness; weakness; flu-like symptoms; leg pain; vision problems; speech problems; problems walking; weight gain; stomach pain; cold sweat; skin rash; blisters; headache; swelling; bleeding; bruising; vomiting blood; jaundice; diarrhea; constipation; dizziness; indigestion; gas; nausea; and ringing in the ears.
In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid. They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.
Mechanism of action
Society and culture
The medication has a cost in the U.S. of $21 (USD) for 20 tablets (750 mg)
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