|Trade names||Disalcid, Salflex, other|
|Other names||Salicylsalicylic acid, sodium salicylate|
|Drug class||NSAID (salicylate)|
|Side effects||Ringing in the ears, nausea, rash, Reye syndrome, stomach bleeding, kidney problems, anaphylaxis|
|Typical dose||1 to 1.5 gram|
|Chemical and physical data|
|Molar mass||258.229 g·mol−1|
Common side effects include ringing in the ears, nausea, and rash. Other side effects may include Reye syndrome, stomach bleeding, kidney problems, liver problems, and anaphylaxis. Use in the later part of pregnancy may harm the baby. It is a nonsteroidal anti-inflammatory drug (NSAID) of the salicylate type and blocks both COX-1 and COX-2.
The typical dose is 1,000 mg three time per day or 1,500 mg twice per day.
Mechanism of action
Relative to other NSAIDs, salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several proinflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein.
The mechanism through which salsalate is thought to reduce the production of these inflammatory chemical signals is through the inhibition of IκB kinase resulting in decreased action of NF-κB genes. This mechanism is thought to be responsible for salsalate's insulin-sensitizing and blood sugar lowering properties.
Society and culture
Salsalate has been proposed for the prevention and treatment of type 2 diabetes due to its ability to lower insulin resistance associated with inflammation and may be useful in prediabetes. However, the use of salsalate to prevent the progression from prediabetes to type 2 diabetes mellitus has received limited study.
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