|Trade names||Disalcid, Salflex, other|
|Other names||Salicylsalicylic acid, sodium salicylate|
|Drug class||NSAID (salicylate)|
|Side effects||Ringing in the ears, nausea, rash, Reye syndrome, stomach bleeding, kidney problems, anaphylaxis|
|Typical dose||1 to 1.5 gram|
|Chemical and physical data|
|Molar mass||258.229 g·mol−1|
|(what is this?)|
Common side effects include ringing in the ears, nausea, and rash. Other side effects may include Reye syndrome, stomach bleeding, kidney problems, liver problems, and anaphylaxis. Use in the later part of pregnancy may harm the baby. It is a nonsteroidal anti-inflammatory drug (NSAID) of the salicylate type and blocks both COX-1 and COX-2.
The typical dose is 1,000 mg three time per day or 1,500 mg twice per day.
Mechanism of action
Relative to other NSAIDs, salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several proinflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein.
The mechanism through which salsalate is thought to reduce the production of these inflammatory chemical signals is through the inhibition of IκB kinase resulting in decreased action of NF-κB genes. This mechanism is thought to be responsible for salsalate's insulin-sensitizing and blood sugar lowering properties.
Society and culture
Salsalate has been proposed for the prevention and treatment of type 2 diabetes due to its ability to lower insulin resistance associated with inflammation and may be useful in prediabetes. However, the use of salsalate to prevent the progression from prediabetes to type 2 diabetes mellitus has received limited study.
- "Salsalate Monograph for Professionals". Drugs.com. Retrieved 10 October 2021.
- Lane, Nancy E.; Wallace, Daniel Jeffrey (2002). All about Osteoarthritis: The Definitive Resource for Arthritis Patients and Their Families. Oxford University Press. p. 165. ISBN 978-0-19-513873-3.
- "Salsalate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 10 October 2021.
- Anderson K, Wherle L, Park M, Nelson K, Nguyen L (June 2014). "Salsalate, an old, inexpensive drug with potential new indications: a review of the evidence from 3 recent studies". American Health & Drug Benefits. 7 (4): 231–5. PMC 4105730. PMID 25126374.
- Hardie DG (July 2013). "AMPK: a target for drugs and natural products with effects on both diabetes and cancer". Diabetes. 62 (7): 2164–72. doi:10.2337/db13-0368. PMC 3712072. PMID 23801715.
- Esser N, Paquot N, Scheen AJ (March 2015). "Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease". Expert Opinion on Investigational Drugs (Review). 24 (3): 283–307. doi:10.1517/13543784.2015.974804. PMID 25345753.
- Ridker PM, Lüscher TF (July 2014). "Anti-inflammatory therapies for cardiovascular disease". European Heart Journal. 35 (27): 1782–91. doi:10.1093/eurheartj/ehu203. PMC 4155455. PMID 24864079.
- Powell K (May 2007). "Obesity: the two faces of fat". Nature. 447 (7144): 525–7. Bibcode:2007Natur.447..525P. doi:10.1038/447525a. PMID 17538594.
- Ebstein W (1876). "Zur therapie des diabetes mellitus, insbesondere uber die anwendung des salicylsauren natron bei demselben". Berliner Klinische Wochenschrift. 13: 337–340.
- drugs.com Salsalate entry
- Cavallito CJ, Buck JS (1943). "Synthesis of Phenolic Acid Esters. I. Depsides1". Journal of the American Chemical Society. 65 (11): 2140. doi:10.1021/ja01251a034.
- Baker W, Ollis WD, Zealley TS (1951). "42. Eight- and higher-membered ring compounds. Part II. Di-, tri-, tetra-, and hexa-salicylides". Journal of the Chemical Society (Resumed): 201. doi:10.1039/JR9510000201.