|Pronunciation||nye sol' di peen|
|Trade names||Sular, Baymycard, Syscor, others|
|Drug class||Calcium channel blocker (dihydropyridine)|
|Main uses||High blood pressure|
|Side effects||Swelling, headache, palpitations, nausea, rash|
|Elimination half-life||7–12 hours|
|Excretion||70–80% via urine|
|Chemical and physical data|
|Molar mass||388.414 g·mol−1|
|3D model (JSmol)|
Common side effects include swelling, headache, palpitations, nausea, and rash. Other side effects may include angina, low blood pressure], and allergic reactions. While use during pregnancy is not well studied, risk is low. It is a calcium channel blocker (CCB) of the dihydropyridine class. It works by resulting in vasodilation of arteries.
Nisoldipine was patented in 1975 and approved for medical use in 1990. It was approved in the United States in 1995. It is available as a generic medication. In the United States it costs about 54 USD per month.
It is often started at 17 mg per day and may be increased to 34 mg per day.
The substance is metabolized by the liver enzyme CYP3A4. Consequently, CYP3A4 inducers such as rifampicin or carbamazepine could reduce the effectiveness of nisoldipine, while CYP3A4 inhibitors such as ketoconazole increase the amount of nisoldipine in the body more than 20-fold. Grapefruit juice also increases nisoldipine concentrations by inhibiting CYP3A4.
Mechanism of action
It is a second generation CCB.
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- Diseases Database (DDB): 30009
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