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Combination of
Esomeprazole magnesiumProton pump inhibitor
Trade namesVimovo
Clinical data
  • AU: C[1]
  • US: C (Risk not ruled out)[1]
Routes of
By mouth
External links
AHFS/Drugs.comProfessional Drug Facts
Legal status

Naproxen/esomeprazole, sold under the brand name Vimovo, is a pain medication. It contains naproxen, an NSAID, and esomeprazole, a proton pump inhibitor (PPI).[2] It is used for osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.[3] It is taken by mouth.

The inclusion of a PPI is intended to decrease the risk of gastric ulcers from treatment with nonsteroidal anti-inflammatory drugs.[3]

It is available as a generic medication.[4] In the United States it costs about 740 USD per month as of 2020.[5] The cost of the individual components; however, is about 23 USD for esomeprazole and 10 USD for naproxen.[6][7]

Side effects

Society and culture

It was originally produced by AstraZeneca. Vimovo was acquired by the Ireland-based company, Horizon Pharma on November 19, 2013. AstraZeneca retained ex-U.S. rights to vimovo.[2]


The medication cost in the U.S. for 60 tablets in delayed release tablet 20 mg-375 mg is $1,082 (USD)[8]

The cost of the naproxen and esomeprazole separately in 2017 was $40 a month. Horizon Pharma bills insurance companies $3,252 a month for Vimovo.[9] According to The Atlantic, "since 2014, Horizon Pharma’s net sales have been more than $455 million".[9]


  1. 1.0 1.1 "Esomeprazole / naproxen (Vimovo) Use During Pregnancy". 11 September 2019. Archived from the original on 29 October 2020. Retrieved 17 August 2020.
  2. 2.0 2.1 "Horizon Pharma Announces Agreement to Acquire U.S. Rights to VIMOVO(R) and Provides 2014 Guidance". Horizon Pharma, Inc. Deerfield, Illinois. November 19, 2013. Archived from the original on July 12, 2017. Retrieved October 16, 2020.(NASDAQ: HZNP)
  3. 3.0 3.1 "VIMOVO® (naproxen and esomeprazole magnesium) Tablets". Horizon Pharma. nd. Archived from the original on June 6, 2017. Retrieved June 20, 2017.
  4. "Drugs@FDA: FDA-Approved Drugs". Archived from the original on 30 September 2020. Retrieved 15 February 2022.
  5. "Vimovo Prices, Coupons & Savings Tips". GoodRx. Archived from the original on 28 January 2021. Retrieved 15 November 2020.
  6. "Esomeprazole Prices, Coupons & Savings Tips". GoodRx. Retrieved 15 November 2020.
  7. "Naproxen Prices, Coupons & Savings Tips". GoodRx. Archived from the original on 19 July 2019. Retrieved 15 November 2020.
  8. "Esomeprazole/naproxen Prices, Coupons & Patient Assistance Programs". Archived from the original on 28 August 2021. Retrieved 29 March 2021.
  9. 9.0 9.1 Allen, Marshall (June 20, 2017). "How Two Common Medications Became One $455 Million Specialty Pill". The Atlantic. Archived from the original on June 30, 2017. Retrieved June 20, 2017. After I was prescribed a brand-name drug I didn’t need and given a coupon to cover the out-of-pocket costs, I discovered yet another reason why Americans pay too much for health care.

External links