|Ipratropium bromide||Muscarinic antagonist|
|Salbutamol||Short-acting β2-adrenergic agonist|
|Trade names||Combivent, DuoNeb, Breva, others|
|Defined daily dose||not established|
|AHFS/Drugs.com||Professional Drug Facts|
Ipratropium bromide/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD). It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist). It is taken by inhalation.
Common side effects include sore throat, muscle cramps, and nausea. Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections. Safety in pregnancy is unclear. Each medication typically decreases bronchospasm and does so via different mechanisms.
The combination was approved for medical use in the United States in 1996. It is available as a generic medication. Sixty doses in the United Kingdom costs the NHS about 18 £ as of 2019. In the United States the wholesale cost of this amount is about US$9.50. In 2017, it was the 172nd most commonly prescribed medication in the United States, with more than three million prescriptions.
Society and culture
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