Vilanterol

From WikiProjectMed
Jump to navigation Jump to search
Vilanterol
Vilanterol.svg
Names
Trade namesWith fluticasone: Breo Ellipta, Relvar Ellipta
With umeclidinium: Anoro Ellipta
With both: Trelegy Ellipta
  • 4-{(1R)-2-[(6-{2-[(2,6-Dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
Clinical data
Main usesCOPD, asthma[1][2]
Side effectsNose and throat irritation, thrush, chest pain[2]
Pregnancy
category
  • AU: B3
Routes of
use
By inhalation
External links
AHFS/Drugs.comMonograph
US NLMVilanterol
Legal
License data
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
Chemical and physical data
FormulaC24H33Cl2NO5
Molar mass486.43 g·mol−1
3D model (JSmol)
  • c1cc(c(c(c1)Cl)COCCOCCCCCCNC[C@@H](c2ccc(c(c2)CO)O)O)Cl
  • InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1
  • Key:DAFYYTQWSAWIGS-DEOSSOPVSA-N

Vilanterol is a medication primarily used to treat chronic obstructive pulmonary disease (COPD).[2] It may also be used to prevent worsening in asthma.[1] It is inhaled in combination with other medications.[1]

Common side effects include nose and throat irritation, thrush, and chest pain.[2] Other side effects may include anaphylaxis and bronchospasm.[2] It is a long-acting β2 adrenoreceptor agonist (LABA).[2]

Vilanterol in combination with fluticasone was approved for medical use in the United States in 2013.[3] It is also avaliable as umeclidinium/vilanterol and fluticasone/umeclidinium/vilanterol.[2][1] In the United Kingdom a month of medication costs the NHS about £20 to £45 as of 2021.[1] In the United States this amount costs about 190 USD.[4]

Medical uses

Combinations

Vilanterol is available in following combinations:

Dosage

It is used by inhalation once per day.[1]

See also

  • Salmeterol—a long-acting β2 adrenoreceptor agonist (LABA) with a similar backbone.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 279. ISBN 978-0-85711-369-6.CS1 maint: date format (link)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Vilanterol Monograph for Professionals". Drugs.com. Retrieved 15 September 2021.
  3. "FDA approves Breo Ellipta to treat chronic obstructive pulmonary disease". web.archive.org. 18 January 2017. Retrieved 15 September 2021.
  4. "Breo Ellipta Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 15 September 2021.

External links

Identifiers: