Clidinium bromide

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Not to be confused with Chlordiazepoxide/clidinium.
Clidinium bromide
Clidinium bromide.svg
Names
  • 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide
Clinical data
Pregnancy
category
  • US: D (Evidence of risk)
Routes of
use		By mouth
External links
AHFS/Drugs.comMonograph
MedlinePlusa601036
Legal
Legal status
Pharmacokinetics
BioavailabilityLow
ExcretionKidney and biliary
Chemical and physical data
FormulaC22H26NO3+
Molar mass352.454 g·mol−1
3D model (JSmol)
  • O=C(OC2C1CC[N+](CC1)(C)C2)C(O)(c3ccccc3)c4ccccc4
  • InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1 checkY
  • Key:HOOSGZJRQIVJSZ-UHFFFAOYSA-N checkY

Clidinium bromide is an anticholinergic (specifically a muscarinic antagonist) medication.[1] It may help symptoms of cramping and abdominal pain by slowing the intestines.

In the United States it is only commercially available in combination with chlordiazepoxide (a benzodiazepine) as chlordiazepoxide/clidinium.[2]

Mechanism of action

Clidinium inhibits muscarinic acetylcholine receptors on smooth muscles, secretory glands, and in the central nervous system to relax smooth muscle and decrease biliary tract secretions.[3]

References

  1. ↑ "Clidinium bromide". Drugs.com. Archived from the original on August 28, 2018. Retrieved August 24, 2013.
  2. ↑ "Clidinium Monograph for Professionals". Drugs.com. Archived from the original on 28 August 2018. Retrieved 5 January 2022.
  3. ↑ 2014 Nurses Drug Handbook (13th ed.). Burlington, MA: Jones & Bartlett Learning. 2014. pp. 245-6. ISBN 978-1-284-03115-7.

External links

Identifiers:
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