|Trade names||Pamine, Extendryl, AlleRx, Others|
|Other names||Methylscopolamine bromide|
|Main uses||Stomach ulcers|
|Side effects||Dry mouth, decreased sweating, blurry vision, increased intraocular pressure|
|Typical dose||2.5 to 5 mg QID|
|Elimination half-life||3–4 hrs|
|Chemical and physical data|
|Molar mass||318.388 g/mol (398.297 g/mol with bromide) g·mol−1|
|3D model (JSmol)|
Methylscopolamine, also known as methscopolamine, was a medication used to treat stomach ulcers. Its use has mostly been replaced by proton pump inhibitors and H2 blockers which are more effective. It is taken by mouth.
Common side effects include dry mouth, decreased sweating, blurry vision, and increased intraocular pressure. Other side effects may include allergic reactions, sleepiness, and heat stroke. It is an antimuscarinic which acts by blocking the acetylcholine.
It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications
It is often take at a dose of 2.5 to 5 mg four times per day.
Mechanism of action
Brand names include Extendryl, AlleRx, Rescon, Pamine.
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