Triprolidine

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Triprolidine
Triprolidine Structural Formula V1.svg
Names
Trade namesActidil, Myidil
With pseudoephedrine: Actifed
  • 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-
    prop-1-enyl]pyridine
Clinical data
Drug classFirst generation antihistamine[1]
Main usesAllergies[1]
Side effectsSleepiness, dry mouth, nausea, dizziness, blurry vision, urinary retention[1]
Pregnancy
category
  • C (US)
Routes of
use
By mouth[1]
External links
AHFS/Drugs.comMonograph
Legal
Legal status
Pharmacokinetics
Bioavailability4% oral
Protein binding90%
MetabolismLiver (CYP2D6)
Elimination half-life4–6 hours
ExcretionKidney
Chemical and physical data
FormulaC19H22N2
Molar mass278.399 g·mol−1
3D model (JSmol)
Melting point60 °C (140 °F)
Solubility in water500 mg/mL (20 °C)
  • n3c(\C(=C\CN1CCCC1)c2ccc(cc2)C)cccc3
  • InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+ checkY
  • Key:CBEQULMOCCWAQT-WOJGMQOQSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Triprolidine, sold under the brand name Zymine among others, is a medication used to treat allergies and the symptoms of the common cold.[1] It is taken by mouth.[1] Use is not recommended in children less than 2 years old.[1]

Common side effects include sleepiness, dry mouth, nausea, dizziness, blurry vision, and urinary retention.[1] Safety in pregnancy is unclear; though use during breastfeeding appears okay.[2] Other side effects may include low blood pressure.[1] It is a first generation antihistamine.[1]

Triprolidine was patented in 1948 and came into medical use in 1953.[3] It is available as a generic medication and over the counter.[4][5] In the United States 30 ml costs less around 20 USD.[4] It may be sold together with other agents such as pseudoephedrine.[1]

Medical uses

Common cold

For the common cold it is not recommended in t hose under 6 years old.[5]

Society and culture

Names

The combination with pseudoephedrine is sold under the brand name Actifed among others.[6]

Cost

The medication in the U.S. has a cost of $21 (USD) for 30 ml oral liquid 0.938 mg/mL[7]

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 "Triprolidine Monograph for Professionals". Drugs.com. Retrieved 20 September 2021.
  2. "Triprolidine Use During Pregnancy". Drugs.com. Retrieved 20 September 2021.
  3. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 546. ISBN 9783527607495.
  4. 4.0 4.1 "Compare Triprolidine Prices - GoodRx". GoodRx. Retrieved 20 September 2021.
  5. 5.0 5.1 "Over-the-counter cough and cold medicines for children". GOV.UK. Retrieved 20 September 2021.
  6. "List of nationally authorised medicinal products" (PDF). Retrieved 20 September 2021.
  7. "Triprolidine Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 9 April 2021.

External links

Identifiers: