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Triprolidine Structural Formula V1.svg
Trade namesActidil, Myidil
With pseudoephedrine: Actifed
  • 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-
Clinical data
Drug classFirst generation antihistamine[1]
Main usesAllergies[1]
Side effectsSleepiness, dry mouth, nausea, dizziness, blurry vision, urinary retention[1]
  • C (US)
Routes of
By mouth[1]
External links
Legal status
Bioavailability4% oral
Protein binding90%
MetabolismLiver (CYP2D6)
Elimination half-life4–6 hours
Chemical and physical data
Molar mass278.399 g·mol−1
3D model (JSmol)
Melting point60 °C (140 °F)
Solubility in water500 mg/mL (20 °C)
  • n3c(\C(=C\CN1CCCC1)c2ccc(cc2)C)cccc3
  • InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+ checkY
 ☒NcheckY (what is this?)  (verify)

Triprolidine, sold under the brand name Zymine among others, is a medication used to treat allergies and the symptoms of the common cold.[1] It is taken by mouth.[1] Use is not recommended in children less than 2 years old.[1]

Common side effects include sleepiness, dry mouth, nausea, dizziness, blurry vision, and urinary retention.[1] Safety in pregnancy is unclear; though use during breastfeeding appears okay.[2] Other side effects may include low blood pressure.[1] It is a first generation antihistamine.[1]

Triprolidine was patented in 1948 and came into medical use in 1953.[3] It is available as a generic medication and over the counter.[4][5] In the United States 30 ml costs less around 20 USD.[4] It may be sold together with other agents such as pseudoephedrine.[1]

Medical uses

Common cold

For the common cold it is not recommended in t hose under 6 years old.[5]

Society and culture


The combination with pseudoephedrine is sold under the brand name Actifed among others.[6]


The medication in the U.S. has a cost of $21 (USD) for 30 ml oral liquid 0.938 mg/mL[7]


  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 "Triprolidine Monograph for Professionals". Retrieved 20 September 2021.
  2. "Triprolidine Use During Pregnancy". Retrieved 20 September 2021.
  3. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 546. ISBN 9783527607495.
  4. 4.0 4.1 "Compare Triprolidine Prices - GoodRx". GoodRx. Retrieved 20 September 2021.
  5. 5.0 5.1 "Over-the-counter cough and cold medicines for children". GOV.UK. Retrieved 20 September 2021.
  6. "List of nationally authorised medicinal products" (PDF). Retrieved 20 September 2021.
  7. "Triprolidine Prices, Coupons & Patient Assistance Programs". Retrieved 9 April 2021.

External links