|Trade names||Afrin, Ocuclear, Drixine, others|
|Other names||Oxymetazoline hydrochloride|
|Drug class||Alpha adrenergic agonist|
|Main uses||Stuffy nose, eye redness|
|Side effects||Burning, nasal discharge|
|Intranasal, eye drops|
|Onset of action||Within 10 min|
|Duration of action||6 hrs|
|Metabolism||Kidney (30%), fecal (10%)|
|Elimination half-life||5–6 hours|
|Chemical and physical data|
|Molar mass||260.381 g·mol−1|
|3D model (JSmol)|
|Melting point||301.5 °C (574.7 °F)|
|(what is this?)|
Oxymetazoline, sold under many brand name, is a medication used to treat a stuffy nose or eye redness due to minor irritation. It is available as a nasal spray or eye drops. Benefits are seen within 10 minutes and last for up to 6 hours. No more than 3 to 5 days of use is recommended; with use recommended against in those under 6 years.
Common side effects may include burning and nasal discharge. Other side effects may include recurrence of stuffiness following stopping use, headache, palpitations, and nervousness. Safety in pregnancy is unclear. It works by activating alpha adrenergic receptor which cases small arteries to narrow.
Oxymetazoline was first made in 1961 and was approved for medical use in the United States in 1986. It is available as a generic medication and over the counter. In the United States 30 ml of solution costs about 12 USD as of 2021.
It is used to treat persistent facial redness associated with rosacea in adults.
Rebound congestion, or rhinitis medicamentosa, may occur. A 2006 review of the pathology of rhinitis medicamentosa concluded that use of oxymetazoline for more than three days may result in rhinitis medicamentosa and recommended limiting use to three days. In a submission to the Therapeutic Goods Administration, a Novartis representative concluded, "The justification was not based on evidence." Citing an existing extensive body of evidence and noting a range of recommended periods from five to ten days, Novartis recommended the established five day period for its use for self-medication without medical consultation as it coincides with the typical duration of the common cold.
The Food and Drug Administration places oxymetazoline in category C, indicating risk to the fetus cannot be ruled out. While it has been shown that a single dose does not significantly alter either maternal or fetal circulation, this subject has not been studied extensively enough to draw reliable conclusions.[original research?]
If accidentally ingested, standard methods to remove unabsorbed drugs should be considered.[clarification needed] There is no specific antidote for oxymetazoline, although its pharmacological effects may be reversed by α adrenergic antagonists such as phentolamine. In the event of a possibly life-threatening overdose (such as a hypertensive crisis), benzodiazepines should be considered to decrease the likelihood of seizures and convulsions, as well as reduce anxiety and to lower blood pressure. In children, oxymetazoline may produce profound central nervous system depression due to stimulation of central α2 receptors and imidazoline receptors, much like clonidine.
Oxymetazoline is a sympathomimetic that selectively agonizes α1 and, partially, α2 adrenergic receptors. Since vascular beds widely express α1 receptors, the action of oxymetazoline results in vasoconstriction. In addition, the local application of the drug also results in vasoconstriction due to its action on endothelial postsynaptic α2 receptors; systemic application of α2 agonists, in contrast, causes vasodilation because of centrally-mediated inhibition of sympathetic tone via presynaptic α2 receptors. Vasoconstriction of vessels results in relief of nasal congestion in two ways: first, it increases the diameter of the airway lumen; second, it reduces fluid exudation from postcapillary venules. It can reduce nasal airway resistance (NAR) up to 35.7% and reduce nasal mucosal blood flow up to 50%.
Imidazolines are sympathomimetic agents, with primary effects on α adrenergic receptors and little if any effect on β adrenergic receptors. Oxymetazoline is readily absorbed orally. Effects on α receptors from systemically absorbed oxymetazoline hydrochloride may persist for up to 7 hours after a single dose. The elimination half-life in humans is 5–8 hours. It is excreted unchanged both by the kidneys (30%) and in feces (10%).
The oxymetazoline brand Afrin was first sold as a prescription medication in 1966. After finding substantial early success as a prescription medication, it became available as an over-the-counter drug in 1975. Schering-Plough did not engage in heavy advertising until 1986.
From the mid 1980s to mid 1990s, the brand Sinex was featured in many television advertisements. Some of these commercials showed men, women, and children using other brands of nasal sprays, and then standing upside down on a sidewalk, or against a wall, etc or hanging upside down from various playground equipment to prevent their nasal spray from dripping out. This was juxtaposed with Sinex users not having to hang upside side down or stand on their heads as it didn't drip out.
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