From WikiProjectMed
Jump to navigation Jump to search
Structural formula of nedocromil
Space-filling model of the nedocromil molecule
Trade namesAlocril, Tilade, Rapitil, others
  • 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Clinical data
Drug classMast cell stabilizer[1]
Main usesAllergic conjunctivitis[1]
Side effectsHeadache, irritated eyes, stuffy nose[1]
Routes of
Inhalation, eye drops
External links
US NLMNedocromil
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Protein binding89%
MetabolismNot metabolized
Elimination half-life~3.3 hours
ExcretionExcreted unchanged
Chemical and physical data
Molar mass371.345 g·mol−1
3D model (JSmol)
  • O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC
  • InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26) checkY

Nedocromil, sold under the brand name Alocil among others, is a medication used to treat allergic conjunctivitis.[1] It is used as an eye drop.[2]

Common side effects include headache, irritated eyes, and stuffy nose.[1] There is no evidence of harm with use in pregnancy.[3] It is a mast cell stabilizer, which decreases the release of histamine.[2]

Nedocromil was approved for medical use in the United States in 1999.[1] In the United States it costs about 230 USD for a 5 ml bottle.[4]

Medical use

It is used to treat allergic conjunctivitis.[5]

It was previously used for asthma.[6]

Society and culture

US Production of inhaled nedocromil stopped in 2008.[7]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 "Nedocromil (EENT) Monograph for Professionals". Retrieved 12 November 2021.
  2. 2.0 2.1 Allen H. Dajani S (ed.). "ALOCRIL (nedocromil sodium) solution/ drops". DailyMed. U.S. National Institutes of Health. Retrieved 17 May 2013.
  3. "Nedocromil ophthalmic (Alocril) Use During Pregnancy". Retrieved 12 November 2021.
  4. "Nedocromil Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 12 November 2021.
  5. Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (June 2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis" (PDF). The Cochrane Database of Systematic Reviews. 6 (6): CD009566. doi:10.1002/14651858.CD009566.pub2. hdl:2164/6048. PMID 26028608.
  6. BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 255. ISBN 978-0857114105.
  7. "Questions and Answers:Phase-Out of CFC Metered-Dose Inhalers Containing flunisolide, triamcinolone, metaproterenol, pirbuterol, albuterol and ipratropium in combination, cromolyn, and nedocromil". U.S. Food and Drug Administration. 13 April 2010. Archived from the original on 2 February 2012.

External links