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Structural formula of nedocromil
Space-filling model of the nedocromil molecule
Trade namesAlocril, Tilade, Rapitil, others
  • 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Clinical data
Drug classMast cell stabilizer[1]
Main usesAllergic conjunctivitis[1]
Side effectsHeadache, irritated eyes, stuffy nose[1]
Routes of
Inhalation, eye drops
External links
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Protein binding89%
MetabolismNot metabolized
Elimination half-life~3.3 hours
ExcretionExcreted unchanged
Chemical and physical data
Molar mass371.345 g·mol−1
3D model (JSmol)
  • O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC
  • InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26) checkY

Nedocromil, sold under the brand name Alocil among others, is a medication used to treat allergic conjunctivitis.[1] It is used as an eye drop.[2]

Common side effects include headache, irritated eyes, and stuffy nose.[1] There is no evidence of harm with use in pregnancy.[3] It is a mast cell stabilizer, which decreases the release of histamine.[2]

Nedocromil was approved for medical use in the United States in 1999.[1] In the United States it costs about 230 USD for a 5 ml bottle.[4]

Medical use

It is used to treat allergic conjunctivitis.[5]

It was previously used for asthma.[6]

Society and culture

US Production of inhaled nedocromil stopped in 2008.[7]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 "Nedocromil (EENT) Monograph for Professionals". Archived from the original on 4 March 2021. Retrieved 12 November 2021.
  2. 2.0 2.1 Allen H. Dajani S (ed.). "ALOCRIL (nedocromil sodium) solution/ drops". DailyMed. U.S. National Institutes of Health. Archived from the original on 20 May 2014. Retrieved 17 May 2013.
  3. "Nedocromil ophthalmic (Alocril) Use During Pregnancy". Archived from the original on 28 November 2020. Retrieved 12 November 2021.
  4. "Nedocromil Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 12 November 2021.
  5. Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (June 2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis" (PDF). The Cochrane Database of Systematic Reviews. 6 (6): CD009566. doi:10.1002/14651858.CD009566.pub2. hdl:2164/6048. PMID 26028608. Archived from the original on 2021-08-28. Retrieved 2021-07-16.
  6. BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 255. ISBN 978-0857114105.
  7. "Questions and Answers:Phase-Out of CFC Metered-Dose Inhalers Containing flunisolide, triamcinolone, metaproterenol, pirbuterol, albuterol and ipratropium in combination, cromolyn, and nedocromil". U.S. Food and Drug Administration. 13 April 2010. Archived from the original on 2 February 2012.

External links