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Pronunciationse vim' e leen[1]
Trade namesEvoxac
  • (2R,2R)-2'-Methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane]
Clinical data
Drug classMuscarinic agonist[1]
Main usesDry mouth[1]
Side effectsIncreased sweating, runny nose, nausea, diarrhea, headaches, dizziness, visual disturbances, tiredness[1]
  • C
Routes of
By mouth (capsules)
External links
Legal status
  • In general: ℞ (Prescription only)
Protein binding<20%
Chemical and physical data
Molar mass199.31 g·mol−1
3D model (JSmol)
  • O1[C@H](SC[C@@]12CN3CCC2CC3)C
  • InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10-/m1/s1 checkY

Cevimeline, sold under the brand name Evoxac, is a medication used to treat dry mouth due to Sjögren's syndrome or radiation therapy.[1] It is similar to pilocarpine.[2] It is taken by mouth.[1]

Side effects are usually mild and may include increased sweating, runny nose, nausea, diarrhea, headaches, dizziness, visual disturbances, and tiredness.[1] Safety in pregnancy is unclear.[2] It is a muscarinic agonist, which results in increased saliva production.[1]

Cevimeline was approved for medical use in the United States in 2000.[2] It is available as a generic medication.[3] In the United States a month of medication costs about 52 USD as of 2021.[3]

Medical use


The typical dose is 30 mg three times daily.[1]

Side effects

Known side effects include nausea, vomiting, diarrhea, excessive sweating, rash, headache, runny nose, cough, drowsiness, hot flashes, blurred vision, and difficulty sleeping.[4]

Contraindications include asthma and angle closure glaucoma.[citation needed]

Mechanism of action

By activating the M3 receptors of the parasympathetic nervous system, cevimeline stimulates secretion by the salivary glands, thereby alleviating dry mouth.

See also

  • Pilocarpine — a similar parasympathomimetic medication for dry mouth (xerostomia)
  • Bethanechol — a similar muscarinic parasympathomimetic with longer-lasting effect


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Cevimeline". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 3 January 2022.
  2. 2.0 2.1 2.2 "Cevimeline Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 3 January 2022. Cite error: Invalid <ref> tag; name "AHFS2022" defined multiple times with different content
  3. 3.0 3.1 "Cevimeline Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 26 September 2016. Retrieved 3 January 2022.
  4. [1] Archived 2017-09-30 at the Wayback Machine MedicineNet: Cevimeline. Accessed 10/12/2007

External links