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Trade namesPrecedex, Dexdor, Dexdomitor, Sileo, others
  • (S)-4-[1-(2,3-Dimethylphenyl)ethyl]-3H-imidazole
Clinical data
Drug classα2-adrenergic agonist[1]
Main usesProcedural sedation, sedation in the ICU[1]
Side effectsLow blood pressure, nausea, dry mouth, abnormal heart rate[1]
  • AU: B1
  • US: C (Risk not ruled out)
Routes of
Intravenous infusion, transmucosal, intranasal
External links
License data
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Protein binding94%
MetabolismNear complete liver metabolism to inactive metabolites
Elimination half-life2 hours
Chemical and physical data
Molar mass200.285 g·mol−1
3D model (JSmol)
  • Cc2cccc([C@H](C)c1c[nH]cn1)c2C
  • InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1 checkY

Dexmedetomidine, sold under the trade name Precedex among others, is a medication used for procedural sedation or sedation in the intensive care unit.[1] It results in mild to moderate sedation without much effect on breathing.[1] It is used by intravenous infusion.[1] Onset of effects may take 25 minutes.[2]

Common side effects include low blood pressure, nausea, dry mouth, and an abnormal heart rate.[1] Other side effects may include agitation, high blood sugar, increased body temperature, and decreased breathing.[3] It works by blocking the α2-adrenergic receptors present in certain parts of the brain.[4]

Dexmedetomidine was approved for medical use in the United States in 1999 and Europe in 2011.[1][5] It is available as a generic medication.[3] In the United Kingdom a 1 mg vial costs about £78 as of 2020.[3] Veterinarians may use it for similar purposes in other animals.[6]

Medical uses


Dexmedetomidine is most often used in the intensive care setting for light to moderate sedation. It is not recommended for long-term deep sedation. A feature of dexmedetomidine is that it has analgesic properties in addition to its role as a hypnotic, but is opioid sparing; thus, it is not associated with significant respiratory depression (unlike propofol).

Many studies suggest dexmedetomidine for sedation in mechanically ventilated adults may reduce time to extubation and ICU stay.[7][8] People on dexmedetomidine can be rousable and cooperative, a benefit in some procedures.

Compared with other sedatives, some studies suggest dexmedetomidine may be associated with less delirium.[9] However, this finding is not consistent across multiple studies.[8] At the very least, when aggregating many study results together, use of dexmedetomidine appears to be associated with less neurocognitive dysfunction compared to other sedatives.[10] Whether this observation has a beneficial psychological impact is unclear.[9]

Procedural sedation

Dexmedetomidine can also be used for procedural sedation such as during colonoscopy.[11] It can be used as an adjunct with other sedatives like benzodiazepines, opioids, and propofol to enhance sedation and help maintain hemodynamic stability by decreasing the requirement of other sedatives.[12][13] Dexmedetomidine is also used for procedural sedation in children.[14]

There is weak evidence that it can be used for sedation required for awake fibreoptic nasal intubation in patients with a difficult airway.[15]


Dexmedetomidine may be useful for the treatment of the negative cardiovascular effects of acute amphetamines and cocaine intoxication and overdose.[16][17] Dexmedetomidine has also been used as an adjunct to neuroaxial anesthesia for lower limb procedures.[18]

Dosage and administration

Intravenous infusion of dexmedetomidine are commonly given at a dose of 0.2–1.4 micrograms/kg/hour.[3] An initial bolus of 0.5 to 1.0 ug/kg over about 15 min may be given.[2]

There are individual variability in the hemodynamic effects (especially on heart rate and blood pressure), as well as the sedative effects. For this reason, the dose must be adjusted to achieve the desired effect.[19]

Side effects

There is no absolute contraindication to the use of dexmedetomidine. It has a biphasic effect on blood pressure with lower readings at lower drug concentrations and higher readings at higher concentrations.[20] Rapid IV administration or bolus has been associated with hypertension due to peripheral α2-receptor stimulation. Bradycardia can be a limiting factor with infusions especially in higher doses.


Dexmedetomidine may enhance the effects of other sedatives and anesthetics when co-administered. Similarly, drugs that lower blood pressure and heart rate, such as beta blockers, may also have enhanced effects when co-administered with dexmedetomidine.[21]



Dexmedetomidine is a highly selective α2-adrenergic agonist. It possesses an α21 selectivity ratio of 1620:1, making it eight times more selective for the α2-receptor than clonidine.[22] Unlike opioids and other sedatives such as propofol, dexmedetomidine is able to achieve its effects without causing respiratory depression. Dexmedetomidine induces sedation by decreasing activity of noradrenergic neurons in the locus ceruleus in the brain stem, thereby increasing the downstream activity of inhibitory gamma-aminobutyric acid (GABA) neurons in the ventrolateral preoptic nucleus.[23] In contrast[clarification needed], other sedatives like propofol and benzodiazepines directly increase activity of gamma-aminobutyric acid neurons.[24] Through action on this endogenous sleep-promoting pathway the sedation produced by dexmedetomidine more closely mirrors natural sleep (specifically stage 2 non-rapid eye movement sleep), as demonstrated by EEG studies.[23][25] As such, dexmedetomidine provides less amnesia than benzodiazepines.[24] Dexmedetomidine also has analgesic effects at the spinal cord level and other supraspinal sites.[24] Thus, unlike other hypnotic agents like propofol, dexmedetomidine can be used as an adjunct medication to help decrease the opioid requirements of people in pain while still providing similar analgesia.


Intravenous dexmedetomidine exhibits linear pharmacokinetics with a rapid distribution half-life of approximately 6 minutes in healthy volunteers, and a longer and more variable distribution half-life in ICU patients.[26] The terminal elimination half-life of intravenous dexmedetomidine ranged 2.1-3.1 hours in healthy adults and 2.2-3.7 hours in ICU patients.[27] Plasma protein binding of dexmedetomidine is about 94% (mostly albumin).[28]

Dexmedetomidine is metabolized by the liver, largely by glucuronidation (34%) as well as by oxidation via CYP2A6 and other Cytochrome P450 enzymes.[27] As such, it should be used with caution in people with liver disease.[21]

The majority of metabolized dexmedetomidine is excreted in the urine (~95%).


Dexmedetomidine was approved in 1999 by the US Food and Drug Administration (FDA) as a short-term sedative and analgesic (<24 hours) for critically ill or injured people on mechanical ventilation in the intensive care unit (ICU). The rationale for its short-term use was due to concerns over withdrawal side effects such as rebound high blood pressure. These effects have not been consistently observed in research studies, however.[29] In 2008 the FDA expanded its indication to include non-intubated people requiring sedation for surgical or non-surgical procedures, such as colonoscopy.

Society and culture


From an economic perspective, dexmedetomidine maybe associated with lower ICU costs in the United States, largely due to a shorter time to extubation.[30]

Veterinary use

Dexmedetomidine, under the trade name Dexdomitor (Orion Corporation), was approved in the European Union in for use in cats and dogs in 2002 for sedation and induction of general anesthesia.[31] The FDA approved dexmedetomidine for use in dogs in 2006 and cats in 2007.[32]

In 2015, the European Medicines Agency and the FDA approved an oromucosal gel form of dexmedetomidine marketed as Sileo (Zoetis) for use in dogs for relief of noise aversion.[33][34]


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  7. Pasin, Laura; Greco, Teresa; Feltracco, Paolo; Vittorio, Annalisa; Neto, Caetano Nigro; Cabrini, Luca; Landoni, Giovanni; Finco, Gabriele; Zangrillo, Alberto (2013-01-01). "Dexmedetomidine as a sedative agent in critically ill patients: a meta-analysis of randomized controlled trials". PLOS ONE. 8 (12): e82913. Bibcode:2013PLoSO...882913P. doi:10.1371/journal.pone.0082913. ISSN 1932-6203. PMC 3877008. PMID 24391726.
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External links

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