Corbadrine

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Corbadrine
Corbadrine.svg
Clinical data
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.113.606 Edit this at Wikidata
Chemical and physical data
FormulaC9H13NO3
Molar mass183.207 g·mol−1
3D model (JSmol)
  • Oc1ccc(cc1O)[C@@H](O)[C@@H](N)C
  • InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1 checkY
  • Key:GEFQWZLICWMTKF-CDUCUWFYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Corbadrine (INN; marketed as Neo-Cobefrine), also known as levonordefrin (USAN) and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States,[1][2] (usually in a pre-mixed solution with local anesthetics, such as mepivacaine).[3]

Corbadrine is also a metabolite of the antihypertensive drug methyldopa,[4] and plays a role in its pharmacology and effects.

See also

References

  1. ^ Morton I, Morton IK, Hall JM (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 164–. ISBN 978-0-7514-0499-9.
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 275–. ISBN 978-3-88763-075-1.
  3. ^ "DailyMed — Search results for levonordefrin". DailyMed. Retrieved 20 February 2016.
  4. ^ Sjoerdsma A, Vendsalu A, Engelman K (October 1963). "Studies on the Metabolism and Mechanism of Action of Methyldopa". Circulation. 28 (4): 492–502. doi:10.1161/01.CIR.28.4.492. PMID 14068757.

External links