Ipratropium/salbutamol

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Ipratropium/salbutamol
Combination of
Ipratropium bromideMuscarinic antagonist
SalbutamolShort-acting β2-adrenergic agonist
Names
Trade namesCombivent, DuoNeb, Breva, others
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)[1]
Routes of
use		Inhalation
Defined daily dosenot established[2]
External links
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa601063
Legal
License data
Legal status
  • AU: S3 (Pharmacist only)
  • UK: POM (Prescription only)
  • US: ℞-only

Ipratropium/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[3][4] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).[3] It is taken by inhalation.[5]

Common side effects include sore throat, muscle cramps, and nausea.[3] Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections.[3] Safety in pregnancy is unclear.[1] Each medication typically decreases bronchospasm and does so via different mechanisms.[3]

The combination was approved for medical use in the United States in 1996.[5] It is available as a generic medication.[4] Sixty doses in the United Kingdom costs the NHS about 18 £ as of 2019.[4] In the United States the wholesale cost of this amount is about US$9.50.[6] In 2017, it was the 172nd most commonly prescribed medication in the United States, with more than three million prescriptions.[7][8]

Medical uses

Dosage

It may be used as 1 inhalation every 4 to 6 hours for COPD.[9] It is available under the brand Combivent Respimat.[9]

The defined daily dose is not established.[2]

Society and culture

Inhalers prior to 2013 contained a chlorofluorocarbon (CFC) based propellant; however, these were removed from the market and replaced with ones that do not contain CFCs.[10] The new version also releases little green house gases, as opposed to single medication salbutamol or ipratropium MDIs.[9]

Cost

In Canada 120 doses costs about 50 CAD as of 2023.[9] Sixty doses in the United Kingdom costs the NHS about 18 £ as of 2019.[4] In the United States the wholesale cost of this amount is about US$9.50.[6]

  • Albuterol/ipratropium costs (US)

    Albuterol/ipratropium costs (US)

  • Albuterol/ipratropium prescriptions (US)

    Albuterol/ipratropium prescriptions (US)

Usage

In 2017, it was the 172nd most commonly prescribed medication in the United States, with more than three million prescriptions.[7][8]

References

  1. ↑ 1.0 1.1 "Albuterol / ipratropium Use During Pregnancy". Drugs.com. Archived from the original on 19 April 2019. Retrieved 19 April 2019.
  2. ↑ 2.0 2.1 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 9 September 2020.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 "DailyMed - ipratropium bromide and albuterol sulfate inhalant". dailymed.nlm.nih.gov. Archived from the original on 17 May 2020. Retrieved 18 April 2019.
  4. ↑ 4.0 4.1 4.2 4.3 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 247. ISBN 9780857113382.
  5. ↑ 5.0 5.1 "Ipratropium and Albuterol - FDA prescribing information, side effects and uses". Drugs.com. Archived from the original on 19 April 2019. Retrieved 18 April 2019.
  6. ↑ 6.0 6.1 "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  7. ↑ 7.0 7.1 "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  8. ↑ 8.0 8.1 "Albuterol Sulfate; Ipratropium Bromide - Drug Usage Statistics". ClinCalc. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
  9. ↑ 9.0 9.1 9.2 9.3 "BC Inhalers". www.bcinhalers.ca. Archived from the original on 30 June 2023. Retrieved 30 June 2023.
  10. ↑ Research, Center for Drug Evaluation and (3 November 2018). "Phase Out of Combivent Inhalation Aerosol - Questions and Answers". FDA. Archived from the original on 27 March 2023. Retrieved 30 June 2023.

External links

Identifiers:
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