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Trade namesSolian, Barhemsys, Socian, Deniban, others
Other namesAPD421
  • 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
Clinical data
Drug classAtypical antipsychotics[1]
Main usesPostoperative nausea and vomiting, schizophrenia[1][2]
Side effectsNausea, breast pain, sexual dysfunction, low potassium[1][2]
Routes of
By mouth, intravenous
External links
US NLMAmisulpride
License data
Legal status
Protein binding16%[7]
MetabolismLiver (minimal; most excreted unchanged)[7]
Elimination half-life12 hours[6]
ExcretionKidney[6] (23–46%),[8][9] Faecal[7]
Chemical and physical data
Molar mass369.48 g·mol−1
3D model (JSmol)
  • O=S(=O)(c1cc(c(OC)cc1N)C(=O)NCC2N(CC)CCC2)CC
  • InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) checkY

Amisulpride, sold under the brand name Solian among others, is a medication used to treat and prevent postoperative nausea and vomiting (PONV) to treat schizophrenia.[1][2] It is taken by mouth or by injection into a vein.[1][2]

Common side effects include nausea, breast pain, sexual dysfunction, and low potassium.[1][2] Other side effects may include QT prolongation, high blood sugar, and abnormal lipids.[1][2] While its safety in pregnancy is unclear, it has caused harm with use in other animals.[10] It is an atypical antipsychotics and is believed to work by blocking the dopamine D2 and D3 receptors.[1]

Amisulpride has been in medical use since 1992.[11] It is available as a generic medication.[1] In the United Kingdom 60 pills of 400 mg costs about £42 as of 2021.[1] In the United States a vial of 5 mg costs about 45 USD.[12]

Medical uses


Although according to other studies it appears to have comparable efficacy to olanzapine in the treatment of schizophrenia.[13] Amisulpride augmentation, similarly to sulpiride augmentation, has been considered a viable treatment option (although this is based on low-quality evidence) in clozapine-resistant cases of schizophrenia.[14][15] Another recent study concluded that amisulpride is an appropriate first-line treatment for the management of acute psychosis.[16]

Postoperative nausea

Amisulpride is indicated for use in the United States in adults for the prevention of postoperative nausea and vomiting (PONV), either alone or in combination with an antiemetic of a different class; and to treat PONV in those who have received antiemetic prophylaxis with an agent of a different class or have not received prophylaxis.[17]


Amisulpride's use is contraindicated in the following disease states[7][18][19]

Neither is it recommended to use amisulpride in patients with hypersensitivities to amisulpride or the excipients found in its dosage form.[7]

Side effects

Very Common (≥10% incidence)[5]
Common (≥1%, <10% incidence)[5][7][20][18][19]
  • Hyperprolactinaemia (which can lead to galactorrhoea, breast enlargement and tenderness, sexual dysfunction, etc.)
  • Weight gain (produces less weight gain than chlorpromazine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zotepine and more (although not statistically significantly) weight gain than haloperidol, lurasidone, ziprasidone and approximately as much weight gain as aripiprazole and asenapine)[21]
  • Anticholinergic side effects (although it does not bind to the muscarinic acetylcholine receptors and hence these side effects are usually quite mild) such as
- constipation
- dry mouth
- disorder of accommodation
- Blurred vision
Rare (<1% incidence)[5][7][20][18][19]

Hyperprolactinaemia results from antagonism of the D2 receptors located on the lactotrophic cells found in the anterior pituitary gland. Amisulpride has a high propensity for elevating plasma prolactin levels as a result of its poor blood-brain barrier penetrability and hence the resulting greater ratio of peripheral D2 occupancy to central D2 occupancy. This means that to achieve the sufficient occupancy (~60–80%[22]) of the central D2 receptors in order to elicit its therapeutic effects a dose must be given that is enough to saturate peripheral D2 receptors including those in the anterior pituitary.[23][24]


The British National Formulary recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse.[25] Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite.[26] Other symptoms may include restlessness, increased sweating, and trouble sleeping.[26] Less commonly there may be a feeling of the world spinning, numbness, or muscle pains.[26] Symptoms generally resolve after a short period of time.[26]

There is tentative evidence that discontinuation of antipsychotics can result in psychosis.[27] It may also result in reoccurrence of the condition that is being treated.[28] Rarely tardive dyskinesia can occur when the medication is stopped.[26]


Torsades de pointes is common in overdose.[29][30] Amisulpride is moderately dangerous in overdose (with the TCAs being very dangerous and the SSRIs being modestly dangerous).[31][32]


Amisulpride should not be used in conjunction with drugs that prolong the QT interval (such as citalopram, bupropion, clozapine, tricyclic antidepressants, sertindole, ziprasidone, etc.),[31] reduce heart rate and those that can induce hypokalaemia. Likewise it is imprudent to combine antipsychotics due to the additive risk for tardive dyskinesia and neuroleptic malignant syndrome.[31]



Site Ki (nM) Species Ref
SERT >10,000 Human [34]
NET >10,000 Human [34]
DAT >10,000 Human [34]
5-HT1A >10,000 Human [34]
5-HT1B 1,744 Human [34]
5-HT1D 1,341 Human [34]
5-HT1E >10,000 Human [34]
5-HT2A 8,304 Human [34]
5-HT2B 13 Human [34]
5-HT2C >10,000 Human [34]
5-HT3 >10,000 Human [34]
5-HT5A >10,000 Human [34]
5-HT6 4,154 Human [34]
5-HT7 11.5 Human [34]
α1A >10,000 Human [34]
α1B >10,000 Human [34]
α1D >10,000 Human [34]
α2A 1,114 Human [34]
α2C 1,540 Human [34]
β1 >10,000 Human [34]
β2 >10,000 Human [34]
β3 >10,000 Human [34]
D1 >10,000 Human [34]
D2 3.0 Human [34]
D3 3.5 Rat [34]
D4 2,369 Human [34]
D5 >10,000 Human [34]
H1 >10,000 Human [34]
H2 >10,000 Human [34]
H4 >10,000 Human [34]
M1 >10,000 Human [34]
M2 >10,000 Human [34]
M3 >10,000 Human [34]
M4 >10,000 Human [34]
M5 >10,000 Human [34]
σ1 >10,000 Rat [34]
σ2 >10,000 Rat [34]
MOR >10,000 Human [34]
DOR >10,000 Human [34]
KOR >10,000 Human [34]
GHBHigh 50 (IC50) Rat [35]
>10,000 Rat [36]
Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site.

Amisulpride functions primarily as a dopamine D2 and D3 receptor antagonist. It has high affinity for these receptors with dissociation constants of 3.0 and 3.5 nM, respectively.[34] Although standard doses used to treat psychosis inhibit dopaminergic neurotransmission, low doses preferentially block inhibitory presynaptic autoreceptors. This results in a facilitation of dopamine activity, and for this reason, low-dose amisulpride has also been used to treat dysthymia.[7]

Amisulpride and its relatives sulpiride, levosulpiride, and sultopride have been shown to bind to the high-affinity GHB receptor at concentrations that are therapeutically relevant (IC50 = 50 nM for amisulpride).[35]

Amisulpride, sultopride and sulpiride respectively present decreasing in vitro affinities for the D2 receptor (IC50 = 27, 120 and 181 nM) and the D3 receptor (IC50 = 3.6, 4.8 and 17.5 nM).[37]

Though it was long widely assumed that dopaminergic modulation is solely responsible for the respective antidepressant and antipsychotic properties of amisulpride, it was subsequently found that the drug also acts as a potent antagonist of the serotonin 5-HT7 receptor (Ki = 11.5 nM).[34] Several of the other atypical antipsychotics such as risperidone and ziprasidone are potent antagonists at the 5-HT7 receptor as well, and selective antagonists of the receptor show antidepressant properties themselves. To characterize the role of the 5-HT7 receptor in the antidepressant effects of amisulpride, a study prepared 5-HT7 receptor knockout mice.[34] The study found that in two widely used rodent models of depression, the tail suspension test, and the forced swim test, those mice did not exhibit an antidepressant response upon treatment with amisulpride.[34] These results suggest that 5-HT7 receptor antagonism mediates the antidepressant effects of amisulpride.[34]

Amisulpride also appears to bind with high affinity to the serotonin 5-HT2B receptor (Ki = 13 nM), where it acts as an antagonist.[34] The clinical implications of this, if any, are unclear.[34] In any case, there is no evidence that this action mediates any of the therapeutic effects of amisulpride.[34]

Amisulpride shows stereoselectivity in its actions.[38] Aramisulpride ((R)-amisulpride) has higher affinity for the 5-HT7 receptor (Ki = 47 nM vs. 1,900 nM) while esamisulpride ((S)-amisulpride) has higher affinity for the D2 receptor (4.0 nM vs. 140 nM).[38][39] An 85:15 ratio of aramisulpride to esamisulpride (SEP-4199) which provides more balanced 5-HT7 and D2 receptor antagonism than racemic amisulpride (50:50 ratio of enantiomers) is under development for the treatment of bipolar depression.[40]

Society and culture

Brand names

Brand names include: Amazeo, Amipride (AU), Amival, Solian (AU, IE, RU, UK, ZA), Soltus, Sulpitac (IN), Sulprix (AU), Midora (RO) and Socian (BR).[41][42]


Amisulpride was not approved by the Food and Drug Administration for use in the United States until February 2020, but it is used in Europe,[42] Israel, Mexico, India, New Zealand and Australia[7] to treat psychosis and schizophrenia.[43][44]

An IV formulation of Amisulpride was approved for the treatment of postoperative nausea and vomiting ("PONV") in the United States in February 2020.[45][17][46]


The U.S. Food and Drug Administration (FDA) approved amisulpride based on evidence from four clinical trials of 2323 subjects undergoing surgery or experiencing nausea and vomiting after the surgery.[46] The trials were conducted at 80 sites in the United States, Canada and Europe.[46]

Two trials (Trials 1 and 2) enrolled subjects scheduled to have surgery.[46] Subjects were randomly assigned to receive either amisulpride or a placebo drug at the beginning of general anesthesia.[46] In Trial 1, subjects received amisulpride or placebo alone, and in Trial 2, they received amisulpride or placebo in combination with one medication approved for prevention of nausea and vomiting.[46] Neither the subjects nor the health care providers knew which treatment was being given until after the trial was complete.[46]

The trials counted the number of subjects who had no vomiting and did not use additional medications for nausea or vomiting in the first day (24 hours) after the surgery.[46] The results then compared amisulpride to placebo.[46]

The other two trials (Trials 3 and 4) enrolled subjects who were experiencing nausea and vomiting after surgery.[46] In Trial 3, subjects did not receive any medication to prevent nausea and vomiting before surgery and in Trial 4 they received the medication, but the treatment did not work.[46] In both trials, subjects were randomly assigned to receive either amisulpride or placebo.[46] Neither the subjects nor the health care providers knew which treatment was being given until after the trial was complete.[46]

The trials counted the number of subjects who had no vomiting and did not use additional medications for nausea or vomiting in the first day (24 hours) after the treatment.[46] The trial compared amisulpride to placebo.[46]


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