Chloracyzine

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Chloracyzine
Identifiers
  • 1-(2-Chloro-10H-phenothiazin-10-yl)-3-(diethylamino)-1-propanone
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H21ClN2OS
Molar mass360.90 g·mol−1
3D model (JSmol)
  • CCN(CC)CCC(=O)N1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
  • InChI=1S/C19H21ClN2OS/c1-3-21(4-2)12-11-19(23)22-15-7-5-6-8-17(15)24-18-10-9-14(20)13-16(18)22/h5-10,13H,3-4,11-12H2,1-2H3
  • Key:ZZKWNLZUYAGVOT-UHFFFAOYSA-N

Chloracyzine is an antidepressant and coronary vasodilator of the phenothiazine class, invented in Russia and used as an anti-anginal agent.[1] It was found not to have antipsychotic activity, but was instead the first Russian tricyclic drug with antidepressant action.[2]

References

  1. ^ Baum T, Wendt RL, Bergey JL (1977). "Chapter 5: Antiarrhythmic and Antianginal Agents". In Clarke FH (ed.). Annual Reports in Medicinal Chemistry. Vol. 12. Elsevier Science. p. 46. doi:10.1016/S0065-7743(08)61543-2. ISBN 978-0-08-058356-3.
  2. ^ ДС Данилов (2019). "История трициклических антидепрессантов и ее значение для современной психофармакотерапии" [History of tricyclic antidepressants and its impact on current psychopharmacotherapy]. Социальная и клиническая психиатрия (in Russian).



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