Dementia with Lewy bodies

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Dementia with Lewy bodies
Other namesDiffuse Lewy body disease
See caption.
Microscopic image of Lewy bodies
SpecialtyNeurology, psychiatry
SymptomsDementia, abnormal behavior during REM sleep, fluctuations in alertness, visual hallucinations, slowness of movement[1]
Usual onsetAfter the age of 50,[2] median 76[3]
DurationLong term[4]
CausesUnknown[4]
Diagnostic methodBased on symptoms and biomarkers[1]
Differential diagnosisAlzheimer's, Parkinson's disease dementia, certain mental illnesses, vascular dementia[5]
MedicationAcetylcholinesterase inhibitors such as donepezil and rivastigmine;[6] melatonin[7]
PrognosisAverage survival 8 years from diagnosis[4]
FrequencyAbout 0.4% of persons older than 65[8]

Dementia with Lewy bodies (DLB) is a type of dementia accompanied by changes in sleep, behavior, cognition, movement, and automatic bodily functions.[9] Memory loss is not always an early symptom.[10] The disease worsens over time and is usually diagnosed when cognitive decline interferes with normal daily functioning.[11][2] Together with Parkinson's disease dementia, DLB is one of the two Lewy body dementias.[9] It is a common form of dementia,[2] but the number of people affected is not known accurately[12][13] and many diagnoses are missed.[14] The disease was first described by Kenji Kosaka in 1976.[15]

REM sleep behavior disorder (RBD)—in which people lose the muscle paralysis that normally occurs during REM sleep and act out their dreams—is a core feature. RBD may appear years or decades before other symptoms. Other core features are visual hallucinations, marked fluctuations in attention or alertness, and parkinsonism (slowness of movement, trouble walking, or rigidity). Not all features must be present for a diagnosis. Definitive diagnosis usually requires an autopsy, but a likely diagnosis is made based on symptoms and tests which may include blood tests, neuropsychological tests, imaging, and sleep studies.[11][2]

Most people with DLB do not have affected family members, although occasionally DLB runs in a family.[4] The exact cause is unknown,[4] but involves widespread deposits of abnormal clumps of protein that form in neurons of the diseased brain.[16] Known as Lewy bodies (discovered in 1912 by Frederic Lewy)[17] and Lewy neurites, these clumps affect both the central nervous system and the autonomic nervous system.[18] Heart function and every level of gastrointestinal function—from chewing to defecation—can be affected, constipation being one of the most common symptoms.[9][19] Low blood pressure upon standing can also be a symptom.[9] DLB also affects behavior; mood changes such as depression and lack of interest are common.[11]

DLB typically begins after the age of fifty[2] and people with the disease live about eight years after diagnosis.[4] There is no cure or medication to stop the disease from progressing,[20] and people in the latter stages of DLB may be unable to care for themselves.[21] Treatments aim to relieve some of the symptoms and reduce the burden on caregivers.[9][22] Medicines such as donepezil and rivastigmine are effective at improving cognition and overall functioning, and melatonin can be used for sleep-related symptoms.[23] Antipsychotics are usually avoided, even for hallucinations, because severe and life-threatening reactions occur in almost half of people with DLB,[24] and their use can result in death.[25] Management of the many different symptoms is challenging, as it involves multiple specialties and education of caregivers.[26][9][11]

Video explanation

Classification

Dementia with Lewy bodies (DLB) is a type of dementia that is progressive and neurodegenerative;[27] that is, it is characterized by degeneration of the central nervous system that worsens over time.

Dementia with Lewy bodies is sometimes classified in other ways. It is one of the two Lewy body dementias, along with Parkinson's disease dementia.[28] The atypical parkinsonian syndromes include DLB, along with other conditions.[29] Lastly, DLB is a synucleinopathy, meaning that it is characterized by abnormal deposits of alpha-synuclein protein in the brain. The synucleinopathies include Parkinson's disease, multiple system atrophy, and other rarer conditions.[30]

Signs and symptoms

DLB is dementia that occurs with "some combination of fluctuating cognition, recurrent visual hallucinations, rapid eye movement (REM) sleep behavior disorder (RBD), and parkinsonism starting with or after the dementia diagnosis", according to Armstrong (2019).[31] DLB has widely varying symptoms and is more complex than many other dementias.[32][21] Several areas of functioning can be affected by Lewy pathology,[lower-alpha 1] in which the alpha-synuclein deposits that cause DLB damage many different regions of the nervous system (such as the autonomic nervous system and numerous regions of the brain).[33]

In DLB, there is an identifiable set of early signs and symptoms; these are called the prodromal phase of the disease. The earliest signs are constipation and dizziness from autonomic dysfunction, reduced ability to smell, visual hallucinations, and REM sleep behavior disorder (RBD).[34] RBD may appear years or decades before other symptoms.[7] Memory loss is not always an early symptom.[35]

The symptoms can be divided into essential, core, and supportive features.[1] Dementia is the essential feature and must be present for diagnosis, while core and supportive features are further evidence in support of diagnosis (see diagnostic criteria below).[36]

Essential feature

A dementia diagnosis is made after cognitive decline progresses to a point of interfering with normal daily activities, or social or occupational function.[36] While dementia is an essential feature of DLB, it does not always appear early on, and is more likely to present as the condition progresses.[36][37]

Core features

While specific symptoms may vary, the core features of DLB are fluctuating cognition, alertness or attention; REM sleep behavior disorder; one or more of the cardinal features of parkinsonism, not due to medication or stroke; and repeated visual hallucinations.[1]

The 2017 Fourth Consensus Report of the DLB Consortium determined these to be core features based on the availability of high-quality evidence indicating they are highly specific to the condition.[36]

Fluctuating cognition, alertness or attention

Besides memory loss, the three most common cognitive symptoms in DLB are impairments of attention, executive function, and visuospatial function.[38] These impairments are present early in the course of the disease.[36] Individuals with DLB may be easily distracted, have a hard time focusing on tasks,[39] or appear to be "delirium-like", "zoning out", or in states of altered consciousness[36] with spells of confusion, agitation or incoherent speech.[40] They may have disorganized speech and their ability to organize their thoughts may change during the day.[5][36] Executive function describes attentional and behavioral controls, memory and cognitive flexibility that aid problem solving and planning.[41] Problems with executive function surface in activities requiring planning and organizing.[8] Deficits can manifest in impaired job performance, inability to follow conversations, difficulties with multitasking, or mistakes in driving, such as misjudging distances or becoming lost.[42] The person with DLB may experience disorders of wakefulness or sleep disorders (in addition to REM sleep behavior disorder) that can be severe.[7] These disorders include daytime sleepiness, drowsiness or napping more than two hours a day, insomnia, periodic limb movements, restless legs syndrome and sleep apnea.[7]

REM sleep behavior disorder

REM sleep behavior disorder
and dementia with Lewy bodies
"REM sleep behavior disorder (RBD) has been studied more thoroughly in correlation with DLB and is now considered a core feature. ... Basically, dementia in the presence of polysomnogram-confirmed RBD suggests possible DLB."

    —B. Tousi (2017), Diagnosis and Management of Cognitive and Behavioral Changes in Dementia With Lewy Bodies.[43]

REM sleep behavior disorder (RBD) is a parasomnia in which individuals lose the paralysis of muscles (atonia) that is normal during rapid eye movement (REM) sleep, and consequently act out their dreams or make other abnormal movements or vocalizations.[44] About 80% of those with DLB have RBD.[45] Abnormal sleep behaviors may begin before cognitive decline is observed,[36] and may appear decades before any other symptoms, often as the first clinical indication of DLB and an early sign of a synucleinopathy.[46] On autopsy, 94 to 98% of individuals with polysomnography-confirmed RBD have a synucleinopathy—most commonly DLB or Parkinson's disease[47][48] in about equal proportions.[49] More than three out of four people with RBD are diagnosed with a neurodegenerative condition within ten years,[50] but additional neurodegenerative diagnoses may emerge up to 50 years after RBD diagnosis.[48] RBD may subside over time.[36]

Individuals with RBD may not be aware that they act out their dreams.[51] RBD behaviors may include yelling, screaming, laughing, crying, unintelligible talking, nonviolent flailing, or more violent punching, kicking, choking, or scratching.[52][53] The reported dream enactment behaviors are frequently violent,[54] and involve a theme of being chased or attacked.[47] People with RBD may fall out of bed or injure themselves or their bed partners,[36][47][53] which may cause bruises, fractures, or subdural hematomae.[55] Because people are more likely to remember or report violent dreams and behaviors—and to be referred to a specialist when injury occurs—recall or selection bias may explain the prevalence of violence reported in RBD.[56]

Parkinsonism

Parkinsonism is a clinical syndrome characterized by slowness of movement, rigidity, postural instability, and tremor;[57][58] it is found in DLB and many other conditions like Parkinson's disease, Parkinson's disease dementia, and others.[58] Parkinsonism occurs in more than 85% of people with DLB, who may have one or more of these cardinal features,[36] although tremor at rest is less common.[59]

Motor symptoms may include shuffling gait, problems with balance, falls, blank expression, reduced range of facial expression, and low speech volume or a weak voice.[2] Presentation of motor symptoms is variable, but they are usually symmetric, presenting on both sides of the body.[60] Only one of the cardinal symptoms of parkinsonism may be present,[1] and the symptoms may be less severe than in persons with Parkinson's disease.[61]

Visual hallucinations

Up to 80% of people with DLB have visual hallucinations, typically early in the course of the disease.[36][62] They are recurrent and frequent; may be scenic, elaborate and detailed;[63] and usually involve animated perceptions of animals or people, including children and family members.[5] Examples of visual hallucinations "vary from 'little people' who casually walk around the house, 'ghosts' of dead parents who sit quietly at the bedside, to 'bicycles' that hang off of trees in the back yard".[64]

These hallucinations can sometimes provoke fear, although their content is more typically neutral.[5] In some cases, the person with DLB may have insight that the hallucinations are not real.[65] Among those with more disrupted cognition, the hallucinations can become more complex, and they may be less aware that their hallucinations are not real.[66]

Visual misperceptions or illusions are also common in DLB but differ from visual hallucinations. While visual hallucinations occur in the absence of real stimuli, visual illusions occur when real stimuli are incorrectly perceived;[66] for example, a person with DLB may misinterpret a floor lamp for a person.[5]

Supportive features

Supportive features of DLB have less diagnostic weight, but they provide evidence for the diagnosis.[36] Supportive features may be present early in the progression, and persist over time; they are common but they are not specific to the diagnosis. The supportive features are:[1]

A sample of haloperidol under the trademark Haldol, 5 mg/ml
People with DLB are very sensitive to antipsychotic medications like haloperidol,[38] which carry an increased risk of morbidity and mortality in DLB.[23][69][70]

Partly because of loss of cells that release the neurotransmitter dopamine, people with DLB may have neuroleptic malignant syndrome, impairments in cognition or alertness, or irreversible exacerbation of parkinsonism including severe rigidity,[54] and dysautonomia from the use of antipsychotics.[70]

Dysautonomia (autonomic dysfunction) occurs when Lewy pathology affects the peripheral autonomic nervous system (the nerves that serve organs such as the intestines, heart, and urinary tract).[33] The first signs of autonomic dysfunction are often subtle.[56] Symptoms include blood pressure problems such as dizziness after standing up (orthostatic hypotension) and supine hypertension;[71] constipation,[72] urinary problems,[73] and sexual dysfunction;[74] loss of or reduced ability to smell;[56][75] and excessive sweating (hyperhidrosis), drooling, or salivation (sialorrhoea), and problems swallowing (dysphagia).[75][76]

Alpha-synuclein deposits can affect cardiac muscle and blood vessels.[77] "Degeneration of the cardiac sympathetic nerves is a neuropathological feature" of the Lewy body dementias, according to Yamada et al.[78] Almost all people with synucleinopathies have cardiovascular dysfunction, although most are asymptomatic.[79] Between 50 and 60% of individuals with DLB have orthostatic hypotension due to reduced blood flow, which can result in lightheadedness, feeling faint, and blurred vision.[77]

From chewing to defecation, alpha-synuclein deposits affect every level of gastrointestinal function.[80][81] Almost all persons with DLB have upper gastrointestinal tract dysfunction (such as gastroparesis, delayed gastric emptying) or lower gastrointestinal dysfunction (such as constipation and prolonged stool transit time).[81] Persons with Lewy body dementias almost universally experience nausea, gastric retention, or abdominal distention from delayed gastric emptying.[81] Problems with gastrointestinal function can affect medication absorption.[80] Constipation can present a decade before diagnosis,[82] and is one of the most common symptoms for people with Lewy body dementias.[80] Dysphagia is milder than in other synucleinopathies and presents later.[83] Urinary difficulties (urinary retention, waking at night to urinate, increased urinary frequency and urgency, and over- or underactive bladder) typically appear later and may be mild or moderate.[84] Sexual dysfunction usually appears early in synucleinopathies, and may include erectile dysfunction and difficulty achieving orgasm or ejaculating.[74]

Among the other supportive features, psychiatric symptoms are often present when the individual first comes to clinical attention and are more likely, compared to AD, to cause more impairment.[85] About one-third of people with DLB have depression, and they often have anxiety as well.[24] Anxiety leads to increased risk of falls,[86] and apathy may lead to less social interaction.[2]

Agitation, behavioral disturbances,[87] and delusions typically appear later in the course of the disease.[5] Delusions may have a paranoid quality, involving themes like a house being broken in to, infidelity,[5] or abandonment.[67] Individuals with DLB who misplace items may have delusions about theft.[5] Capgras delusion may occur, in which the person with DLB loses knowledge of the spouse, caregiver, or partner's face,[88] and is convinced that an imposter has replaced them.[5] Hallucinations in other modalities are sometimes present, but are less frequent.[67]

Sleep disorders (disrupted sleep cycles, sleep apnea, and arousal from periodic limb movement disorder) are common in DLB and may lead to hypersomnia.[89]Loss of sense of smell may occur several years before other symptoms.[34]

Causes

See caption.
A ribbon diagram of apolipoprotein E. Variants of this protein influence the risk of developing DLB.[90]

Like other synucleinopathies,[91] the exact cause of DLB is unknown.[17] Synucleinopathies are typically caused by interactions of genetic and environmental influences.[91] Most people with DLB do not have affected family members, although occasionally DLB runs in a family.[4] The heritability of DLB is thought to be around 30% (that is, about 70% of traits associated with DLB are not inherited).[92]

There is overlap in the genetic risk factors for DLB, Alzheimer's disease, Parkinson's disease, and Parkinson's disease dementia.[90][93] The APOE gene has three common variants. One, APOE ε4, is a risk factor for DLB and Alzheimer's disease, whereas APOE ε2 may be protective against both.[90][94] Mutations in GBA, a gene for a lysosomal enzyme, are associated with both DLB and Parkinson's disease.[95] Rarely, mutations in SNCA, the gene for alpha-synuclein, or LRRK2, a gene for a kinase enzyme, can cause any of DLB, Alzheimer's disease, Parkinson's disease or Parkinson's disease dementia.[90] This suggests some shared genetic pathology may underlie all four diseases.[90]

The greatest risk of developing DLB is being over the age of 50. Having REM sleep behavior disorder or Parkinson's disease confer a higher risk for developing DLB. Risk of developing DLB has not been linked to any specific lifestyle factors.[2] Risk factors for rapid conversion of RBD to a synucleinopathy include impairments in color vision or the ability to smell, mild cognitive impairment, and abnormal dopaminergic imaging.[96]

Pathophysiology

See cation.
This photomicrograph shows brown-immunostained alpha-synuclein in Lewy bodies (large clumps) and Lewy neurites (thread-like structures) in the neocortical tissue of a person who died with Lewy body disease.

DLB is characterized by the development of abnormal collections of alpha-synuclein protein within diseased brain neurons, known as Lewy bodies and Lewy neurites.[90] When these clumps of protein form, neurons function less optimally and eventually die.[21] Neuronal loss in DLB leads to profound dopamine dysfunction[97] and marked cholinergic pathology;[98] other neurotransmitters might be affected, but less is known about them.[99] Damage in the brain is widespread, and affects many domains of functioning.[21][lower-alpha 1] Loss of acetylcholine-producing neurons is thought to account for degeneration in memory and learning, while the death of dopamine-producing neurons appears to be responsible for degeneration of behavior, cognition, mood, movement, motivation, and sleep.[2] The extent of Lewy body neuronal damage is a key determinant of dementia in the Lewy body disorders.[101][102]

The precise mechanisms contributing to DLB are not well understood and are a matter of some controversy.[103] The role of alpha-synuclein deposits is unclear, because individuals with no signs of DLB have been found on autopsy to have advanced alpha-synuclein pathology.[90] The relationship between Lewy pathology and widespread cell death is contentious.[103] It is not known if the pathology spreads between cells or follows another pattern.[104] The mechanisms that contribute to cell death, how the disease advances through the brain, and the timing of cognitive decline are all poorly understood.[103] There is no model to account for the specific neurons and brain regions that are affected.[103]

Autopsy studies and amyloid imaging studies using Pittsburgh compound B (PiB)[105] indicate that tau protein pathology and amyloid plaques,[106] which are hallmarks of AD,[107] are also common in DLB[108] and more common than in Parkinson's disease dementia.[109] Amyloid-beta (Aβ) deposits are found in the tauopathies—neurodegenerative diseases characterized by neurofibrillary tangles of hyperphosphorylated tau protein[107][110][111]—but the mechanism underlying dementia is often mixed, and Aβ is also a factor in DLB.[112]

A proposed pathophysiology for RBD implicates neurons in the reticular formation that regulate REM sleep. RBD might appear decades earlier than other symptoms in the Lewy body dementias because these cells are affected earlier, before spreading to other brain regions.[52]

Diagnosis

Dementia with Lewy bodies can only be definitively diagnosed after death with an autopsy of the brain (or in rare familial cases, via a genetic test),[2] so diagnosis of the living is referred to as probable or possible.[36] Diagnosing DLB can be challenging because of the wide range of symptoms with differing levels of severity in each individual.[3] DLB is often misdiagnosed[20] or, in its early stages, confused with AD.[113] As many as one in three diagnoses of DLB may be missed.[114] Another complicating factor is that DLB can occur along with Alzheimer's disease (AD); autopsy reveals that most people with DLB have some level of changes attributed to AD in their brains, which contributes to the wide-ranging variety of symptoms and diagnostic difficulty.[3][115][116] Despite the difficulty in diagnosis, a prompt diagnosis is important because of the serious risks of sensitivity to antipsychotics and the need to inform both the person with DLB and the person's caregivers about those medications' side effects.[69][117] The management of DLB is difficult in comparison to many other neurodegenerative diseases, so an accurate diagnosis is important.[32]

Criteria

The 2017 Fourth Consensus Report established diagnostic criteria for probable and possible DLB, recognizing advances in detection since the earlier Third Consensus (2005)[118] version.[lower-alpha 2] The 2017 criteria are based on essential, core, and supportive clinical features, and diagnostic biomarkers.[1]

The essential feature is dementia; for a DLB diagnosis, it must be significant enough to interfere with social or occupational functioning.[36]

The four core clinical features (described in the Signs and symptoms section) are fluctuating cognition, visual hallucinations, REM sleep behavior disorder, and signs of parkinsonism. Supportive clinical features are marked sensitivity to antipsychotics; marked autonomic dysfunction; nonvisual hallucinations; hypersomnia; reduced ability to smell; false beliefs and delusions organized around a common theme; postural instability, loss of consciousness and frequent falls; and apathy, anxiety, or depression.[1][68]

A man is lying on his back, about to go inside a cylindrical chamber.
Positron emission tomography, for example, using PiB is helpful in the diagnosis of DLB.[36][105]

Direct laboratory-measurable biomarkers for DLB diagnosis are not known, but several indirect methods can lend further evidence for diagnosis.[36]The indicative diagnostic biomarkers are: reduced dopamine transporter uptake in the basal ganglia shown on PET or SPECT imaging; low uptake of 123iodine-metaiodobenzylguanidine (123I-MIBG) shown on myocardial scintigraphy; and loss of atonia during REM sleep evidenced on polysomnography. Supportive diagnostic biomarkers (from PET, SPECT, CT, or MRI brain imaging studies or EEG monitoring) are: lack of damage to medial temporal lobe; reduced occipital activity; and prominent slow-wave activity.[36]

Probable DLB can be diagnosed when dementia and at least two core features are present, or when one core feature and at least one indicative biomarker are present. Possible DLB can be diagnosed when dementia and only one core feature are present or, if no core features are present, then at least one indicative biomarker is present.[36][120]

DLB is distinguished from Parkinson's disease dementia by the time frame in which dementia symptoms appear relative to parkinsonian symptoms. DLB is diagnosed when cognitive symptoms begin before or at the same time as parkinsonian motor signs. Parkinson's disease dementia would be the diagnosis when Parkinson's disease is well established before the dementia occurs (the onset of dementia is more than a year after the onset of parkinsonian symptoms).[121]

DLB is listed in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) as major or mild neurocognitive disorder with Lewy bodies.[90] The differences between the DSM and DLB Consortium diagnostic criteria are: 1) the DSM does not include low dopamine transporter uptake as a supportive feature, and 2) unclear diagnostic weight is assigned to biomarkers in the DSM.[76]

Clinical history and testing

Diagnostic tests can be used to establish some features of the condition and distinguish them from symptoms of other conditions. Diagnosis may include taking the person's medical history, a physical exam, assessment of neurological function, testing to rule out conditions that may cause similar symptoms, brain imaging, neuropsychological testing to assess cognitive function,[2][122] sleep studies, or myocardial scintigraphy.[36] Laboratory testing can rule out other conditions that can cause similar symptoms, such as abnormal thyroid function, syphilis, HIV, or vitamin deficiencies that may cause symptoms similar to dementia.[122][123]

Dementia screening tests are the Mini-Mental State Examination and the Montreal Cognitive Assessment.[38] For tests of attention, digit span, serial sevens, and spatial span can be used for simple screening, and the Revised Digit Symbol Subtest of the Wechsler Adult Intelligence Scale may show defects in attention that are characteristic of DLB.[124] The Frontal Assessment Battery, Stroop test and Wisconsin Card Sorting Test are used for evaluation of executive function, and there are many other screening instruments available.[125]

A plethora of wires are brought together in a box fastened just above the waist.
Adult connected to wires from sensors for polysomnography

If DLB is suspected when parkinsonism and dementia are the only presenting features, PET or SPECT imaging may show reduced dopamine transporter activity. A DLB diagnosis may be warranted if other conditions with reduced dopamine transporter uptake can be ruled out.[36]

RBD is diagnosed either by sleep study recording or, when sleep studies cannot be performed, by medical history and validated questionnaires.[36][55][lower-alpha 3] In individuals with dementia and a history of RBD, a probable DLB diagnosis can be justified (even with no other core feature or biomarker) based on a sleep study showing REM sleep without atonia because it is so highly predictive.[36] Conditions similar to RBD, like severe sleep apnea and periodic limb movement disorder, must be ruled out.[36] Prompt evaluation and treatment of RBD is indicated when a prior history of violence or injury is present as it may increase the likelihood of future violent dream enactment behaviors.[53] Individuals with RBD may not be able to provide a history of dream enactment behavior, so bed partners are also consulted.[36][56] The REM Sleep Behavior Disorder Single-Question Screen offers diagnostic sensitivity and specificity in the absence of polysomnography with one question:[55] "Have you ever been told, or suspected yourself, that you seem to 'act out your dreams' while asleep (for example, punching, flailing your arms in the air, making running movements, etc.)?"[126]

Since 2001, 123iodine-metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy has been used diagnostically in East Asia (principally Japan), but not in the United States.[43][127][128] MIBG is taken up by sympathetic nerve endings, such as those that innervate the heart, and is labeled for scintigraphy with radioactive 123iodine.[128] Autonomic dysfunction resulting from damage to nerves in the heart in patients with DLB is associated with lower cardiac uptake of 123I-MIBG.[128]

There is no genetic test to determine if an individual will develop DLB[2][36] and, according to the Lewy Body Dementia Association, genetic testing is not routinely recommended because there are only rare instances of hereditary DLB.[129]

Differential

Many neurodegenerative conditions share cognitive and motor symptoms with dementia with Lewy bodies. The differential diagnosis includes Alzheimer's disease; such synucleinopathies as Parkinson's disease dementia, Parkinson's disease, and multiple system atrophy; vascular dementia; and progressive supranuclear palsy, corticobasal degeneration, and corticobasal syndrome.[5]

The symptoms of DLB are easily confused with delirium,[130] or more rarely as psychosis.[113] Mismanagement of delirium is a particular concern because of the risks to people with DLB associated with antipsychotics.[130] PET or SPECT imaging showing reduced dopamine transporter uptake can help distinguish DLB from delirium.[130]

Lewy pathology affects the peripheral autonomic nervous system; autonomic dysfunction is observed less often in AD, frontotemporal, or vascular dementias, so its presence can help differentiate them.[131] MRI scans almost always show abnormalities in the brains of people with vascular dementia, which can begin suddenly.[132]

Alzheimer's disease

DLB is distinguishable from AD even in the prodromal phase.[34] Short-term memory impairment is seen early in AD and is a prominent feature, while fluctuating attention is uncommon; impairment in DLB is more often seen first as fluctuating cognition.[133] In contrast to AD—in which the hippocampus is among the first brain structures affected, and episodic memory loss related to encoding of memories is typically the earliest symptom—memory impairment occurs later in DLB.[42][134] People with amnestic mild cognitive impairment (in which memory loss is the main symptom) may progress to AD, whereas those with non-amnestic mild cognitive impairment (which has more prominent impairments in language, visuospatial, and executive domains) are more likely to progress towards DLB.[135] Memory loss in DLB has a different progression from AD because frontal structures are involved earlier, with later involvement of temporoparietal brain structures.[134] Verbal memory is not as severely affected as in AD.[136]

While 74% of people with autopsy-confirmed DLB had deficits in planning and organization, they show up in only 45% of people with AD.[137] Visuospatial processing deficits are present in most individuals with DLB,[69] and they show up earlier and are more pronounced than in AD.[138] Hallucinations typically occur early in the course of DLB,[5] are less common in early AD, but usually occur later in AD.[88] AD pathology frequently co-occurs in DLB, so the cerebrospinal fluid testing for Aβ and tau protein that is often used to detect AD is not useful in differentiating AD and DLB.[60]

PET or SPECT imaging can be used to detect reduced dopamine transporter uptake and distinguish AD from DLB.[60][139] Severe atrophy of the hippocampus is more typical of AD than DLB.[140] Before dementia develops (during the mild cognitive impairment phase), MRI scans show normal hippocampal volume. After dementia develops, MRI shows more atrophy among individuals with AD, and a slower reduction in volume over time among people with DLB than those with AD.[38] Compared to people with AD, FDG-PET brain scans in people with DLB often show a cingulate island sign.[38]

In East Asia, particularly Japan,123I-MIBG is used in the differential diagnosis of DLB and AD, because reduced labeling of cardiac nerves is seen only in Lewy body disorders.[113][128] Other indicative and supportive biomarkers are useful in distinguishing DLB and AD (preservation of medial temporal lobe structures, reduced occipital activity, and slow-wave EEG activity).[36]

Synucleinopathies

Dementia with Lewy bodies and Parkinson's disease dementia are clinically similar after dementia occurs in Parkinson's disease.[141] Delusions in Parkinson's disease dementia are less common than in DLB,[142] and persons with Parkinson's disease are typically less caught up in their visual hallucinations than those with DLB.[88] There is a lower incidence of tremor at rest in DLB than in Parkinson's disease, and signs of parkinsonism in DLB are more symmetrical.[45] In multiple system atrophy, autonomic dysfunction appears earlier and is more severe,[42] and is accompanied by uncoordinated movements, while visual hallucinations and fluctuating cognition are less common than in DLB.[143] Urinary difficulty is one of the earliest symptoms with multiple system atrophy, and is often severe.[73]

Frontotemporal dementias

Corticobasal syndrome, corticobasal degeneration and progressive supranuclear palsy are frontotemporal dementias[144] with features of parkinsonism and impaired cognition. Similar to DLB, imaging may show reduced dopamine transporter uptake. Corticobasal syndrome and degeneration, and progressive supranuclear palsy, are usually distinguished from DLB by history and examination. Motor movements in corticobasal syndrome are asymmetrical. There are differences in posture, gaze and facial expressions in the most common variants of progressive supranuclear palsy, and falling backwards is more common relative to DLB. Visual hallucinations and fluctuating cognition are unusual in corticobasal degeneration and progressive supranuclear palsy.[144]

Management

Palliative care is offered to ameliorate symptoms, but there are no medications that can slow, stop, or improve the relentless progression of the disease.[145] No medications for DLB are approved by the United States Food and Drug Administration as of 2019, although donepezil is licensed in Japan and the Philippines for the treatment of DLB.[146] As of 2020, there has been little study on the best management for non-motor symptoms such as sleep disorders and autonomic dysfunction; most information on management of autonomic dysfunction in DLB is based on studies of people with Parkinson's disease.[147]

Management can be challenging because of the need to balance treatment of different symptoms: cognitive dysfunction, neuropsychiatric features, impairments related to the motor system, and other nonmotor symptoms.[148] Individuals with DLB have widely different symptoms that fluctuate over time, and treating one symptom can worsen another; suboptimal care can result from a lack or coordination among the physicians treating different symptoms.[147] A multidisciplinary approach—going beyond early and accurate diagnosis to include educating and supporting the caregivers—is favored.[23][149]

Medication

Antipsychotic sensitivity
"The most fraught decision in the management of DLB relates to the use of antipsychotic medications ... DLB patients are particularly at risk of antipsychotic medication morbidity and mortality."

    —B.P. Boot (2015), Comprehensive treatment of dementia with Lewy bodies[70]

Pharmacological management of DLB is complex because of adverse effects to medications[52] and the wide range of symptoms to be treated (cognitive, motor, neuropsychiatric, autonomic, and sleep).[23][32] Anticholinergic and dopaminergic agents can have adverse effects or result in psychosis in individuals with DLB,[23] and a medication that addresses one feature might worsen another.[18] For example, acetylcholinesterase inhibitors (AChEIs) for cognitive symptoms can lead to complications in dysautonomia features; treatment of movement symptoms with dopamine agonists may worsen neuropsychiatric symptoms; and treatment of hallucinations and psychosis with antipsychotics may worsen other symptoms or lead to a potentially fatal reaction.[148]

Extreme caution is required in the use of antipsychotic medication in people with DLB because of their sensitivity to these agents.[lower-alpha 4] Severe and life-threatening reactions occur in almost half of people with DLB,[24][69] and can be fatal after a single dose.[70] Antipsychotics with D2 dopamine receptor-blocking properties are used only with great caution.[67] According to Boot (2013), "electing not to use neuroleptics is often the best course of action".[151] People with Lewy body dementias who take neuroleptics are at risk for neuroleptic malignant syndrome, a life-threatening illness.[54] There is no evidence to support the use of antipsychotics to treat the Lewy body dementias,[24] and they carry the additional risk of stroke when used in the elderly with dementia.[89]

Medications (including tricyclic antidepressants and treatments for urinary incontinence) with anticholinergic properties that cross the blood-brain barrier can cause memory loss.[152] The antihistamine medication diphenhydramine (Benadryl), sleep medications like zolpidem,[152] and benzodiazepines may worsen confusion[153] or neuropsychiatric symptoms.[154] Some general anesthetics may cause confusion or delirium upon waking in persons with Lewy body dementias, and may result in permanent decline.[2]

Cognitive symptoms

There is strong evidence for the use of AChEIs to treat cognitive problems; these medications include rivastigmine and donepezil.[3][6] Both are first-line treatments in the UK.[6] Even when the AChEIs do not lead to improvement in cognitive symptoms, people taking them may have less deterioration overall,[6] although there may be adverse gastrointestinal effects.[155] The use of these medications has demonstrated a reduced burden on caregivers, and improvement in activities of daily living for the individual with DLB.[6] The AChEIs are initiated carefully as they may aggravate autonomic dysfunction or sleep behaviors.[156] There is less evidence for the efficacy of memantine in DLB,[6] but it may be used alone or with an AChEI because of its low side effect profile.[23] Anticholinergic drugs are avoided because they worsen cognitive symptoms.[155]

To improve daytime alertness, there is mixed evidence for the use of stimulants such as methylphenidate and dextroamphetamine; although worsening of neuropsychiatric symptoms is not common, they can increase the risk of psychosis.[157] Modafinil and armodafinil may be effective for daytime sleepiness.[158]

Motor symptoms

Motor symptoms in DLB appear to respond somewhat less to medications used to treat Parkinson's disease, like levodopa, and these medications can increase neuropsychiatric symptoms.[23][59] Almost one out of every three individuals with DLB develops psychotic symptoms from levadopa.[59] If such medications are needed for motor symptoms, cautious introduction with slow increases to the lowest possible dose may help avoid psychosis.[23]

Neuropsychiatric symptoms

Neuropsychiatric symptoms of DLB (aggression, anxiety, apathy, delusions, depression and hallucinations) do not always require treatment.[24] The first line of defense in decreasing visual hallucinations is to reduce the use of dopaminergic drugs, which can worsen hallucinations.[155] If new neuropsychiatric symptoms appear, the use of medications (such as anticholinergics, tricyclic antidepressants, benzodiazepines and opioids) that might be contributing to these symptoms is reviewed.[159]

Among the AChEIs, rivastigmine, donepezil, and galantamine can help reduce neuropsychiatric symptoms,[24] and improve the frequency and severity of hallucinations in the less severe stages of DLB.[64] Although it has been shown effective in Parkinson's disease, there is limited evidence for the use of clozapine to treat visual hallucinations in DLB, and its use requires regular blood monitoring.[155] Quetiapine is relatively safe[23] and well tolerated for psychosis and agitation in DLB, but there is little evidence for its efficacy.[160]

Apathy may be treated with AChEIs, and they may also reduce hallucinations, delusions, anxiety and agitation.[23] Most medications to treat anxiety and depression have not been adequately investigated for DLB.[24] Antidepressants may affect sleep and worsen RBD.[7][24][86] Mirtazapine and SSRIs can be used to treat depression, depending on how well they are tolerated, and guided by general advice for the use of antidepressants in dementia.[23] Antidepressants with anticholinergic properties may worsen hallucinations and delusions.[89] People with Capgras syndrome may not tolerate AChEIs.[67]

Sleep disorders

Injurious dream enactment behaviors are a treatment priority.[53] RBD may be treated with melatonin or clonazepam.[161] Sleep medications are carefully evaluated for each individual as they carry increased risk of falls, increased daytime sleepiness, and worsening cognition.[7] Melatonin may be more helpful in preventing injuries,[162] and it offers a safer alternative, because clonazepam can produce deteriorating cognition,[23] and worsen sleep apnea.[162] For some people, memantine is useful.[7] Modafinil may be used for hypersomnia, but no trials support its use in DLB.[89] Mirtazapine can be used for hypersomnia, but it can exacerbate RBD.[89] Antidepressants (SSRIs, SNRIs, tricyclics, and MAOIs), AChEIs, beta blockers, caffeine, and tramadol may worsen RBD.[162]

Autonomic symptoms

Decreasing the dosage of dopaminergic or atypical antipsychotic drugs may be needed with orthostatic hypotension, and high blood pressure drugs can sometimes be stopped.[89] When non-pharmacological treatments for orthostatic hypotension have been exhausted, fludrocortisone, droxidopa, or midodrine are options,[163] but these drugs have not been specifically studied for DLB as of 2020.[80] Delayed gastric emptying can be worsened by dopaminergic medications, and constipation can be worsened by opiates and anticholinergic medications.[80] Muscarinic antagonists used for urinary symptoms might worsen cognitive impairment in people with Lewy body dementias.[80]

Other

There is no high-quality evidence for non-pharmacological management of DLB,[23][80] but some interventions have been shown effective for addressing similar symptoms that occur in other dementias.[164] For example, organized activities, music therapy, physical activity and occupational therapy may help with psychosis or agitation, while exercise and gait training can help with motor symptoms.[164] Cognitive behavioral therapy can be tried for depression or hallucinations, although there is no evidence for its use in DLB.[165] Cues can be used to help with memory retrieval.[42]

The first steps in managing sleep disorders are to evaluate the use of medications that impact sleep and provide education about sleep hygiene.[7] Frequency and severity of RBD may be lessened by treating sleep apnea, if it is present.[161]

For autonomic dysfunction, several non-medication strategies may be helpful. Dietary changes include avoiding meals high in fat[80] and sugary foods, eating smaller and more frequent meals,[166] after-meal walks, and increasing fluids or dietary fiber to treat constipation.[80] Stool softeners and exercise also help with constipation.[80] Excess sweating can be helped by avoiding alcohol and spicy foods, and using cotton bedding and loose fitting clothing.[80]

Physical exercise in a sitting or recumbent position, and exercise in a pool, can help maintain conditioning.[167] Compression stockings and elevating the head of the bed may also help, and increasing fluid intake or table salt can be tried to reduce orthostatic hypotension.[80] To lessen the risk of fractures in individuals at risk for falls, bone mineral density screening and testing of vitamin D levels are used,[168] and caregivers are educated on the importance of preventing falls.[169] Physiotherapy has been shown helpful for Parkinson's disease dementia, but as of 2020, there is no evidence to support physical therapy in people with DLB.[59]

Caregiving

Teaching caregivers how to manage neuropsychiatric symptoms (such as agitation and psychosis) is recommended.[168] Because of the neuropsychiatric symptoms associated with DLB, the demands placed on caregivers are higher than in AD,[18] but education for caregivers has not been studied as thoroughly as in AD or Parkinson's disease.[23] Contributing factors to the caregiver burden in DLB are emotional fluctuations,[18] psychosis, aggression, agitation, and night-time behaviors such as parasomnias,[130] that lead to a loss of independence earlier than in AD.[170] Caregivers may experience depression and exhaustion, and they may need support from other people.[171] Other family members who are not present in the daily caregiving may not observe the fluctuating behaviors or recognize the stress on the caregiver, and conflict can result when family members are not supportive.[2] Caregiver education reduces not only distress for the caregiver, but symptoms for the individual with dementia.[164]

Visual hallucinations associated with DLB create a particular burden on caregivers.[172] Educating caregivers on how to distract or change the subject when confronted with hallucinations is more effective than arguing over the reality of the hallucination.[173][174] Coping strategies may help and are worth trying, even though there is no evidence for their efficacy.[175] These strategies include having the person with DLB look away or look at something else, focus on or try to touch the hallucination, wait for it to go away on its own, and speak with others about the visualization.[176] Delusions and hallucinations may be reduced by increasing lighting in the evening, and making sure there is no light at night when the individual with DLB is sleeping.[173]

With the increased risk of side effects from antipsychotics for people with DLB, educated caregivers are able to act as advocates for the person with DLB.[177] If evaluation or treatment in an emergency room is needed, the caregiver may be able to explain the risks associated with neuroleptic use for persons with DLB.[54] Caregiver training, watchful waiting, identifying sources of pain, and increasing social interaction can help minimize agitation.[87] Individuals with dementia may not be able to communicate that they are in pain, and pain is a common trigger of agitation.[178] Medical alert bracelets or notices about medication sensitivity are available and can save lives.[179] A home safety assessment can be done when there is risk of falling.[23] Handrails and shower chairs can help avoid falls.[180]

Individuals and their caregivers can be counselled about the need to improve bedroom safety for RBD symptoms.[181] Sleep-related injuries from falling or jumping out of bed can be avoided by lowering the height of the bed,[7] placing a mattress next to the bed to soften the impact of a fall, and removing sharp objects from around the bed.[7] Sharp surfaces near the bed can be padded, bed alarm systems may help with sleepwalking, and bed partners may find it safer to sleep in another room.[181] According to St Louis and Boeve, firearms should be locked away, out of the bedroom.[181]

Driving ability may be impaired early in DLB because of visual hallucinations, movement issues related to parkinsonism, and fluctuations in cognitive ability, and at some point it becomes unsafe for the person to drive.[182] Driving ability is assessed as part of management, and family members generally determine when driving privileges are removed.[182][180]

Prognosis

The prognosis for DLB has not been well studied; early studies had methodological limitations, such as small sample size and selection bias.[183] Relative to AD, DLB generally leads to higher disability, lower life expectancy and a reduced quality of life, with increased costs of care.[184] Depression, apathy, and visual hallucinations contribute to the reduced quality of life.[185] Decline may be more rapid when severe visuospatial deficits show up early in the course of the Lewy body dementias,[186] when the APOE gene is present, or when AD—or its biomarkers—is also present.[187] The severity of orthostatic hypotension also predicts a worse prognosis.[188]

Compared to AD, which is better studied, memory is retained longer, while verbal fluency may be lost faster.[187] There are more neuropsychiatric symptoms in DLB than AD, and they may emerge earlier, so those with DLB may have a less favorable prognosis, with more rapid cognitive decline, more admissions to residential care, and a lower life expectancy.[189][183] An increased rate of hospitalization compared to AD is most commonly related to hallucinations and confusion, followed by falls and infection.[190]

Life expectancy is difficult to predict, and limited study data are available.[171] Survival may be defined from the point of disease onset, or from the point of diagnosis.[191] A 2017 review found survival from disease onset between 5.5 and 7.7 years, survival from diagnosis between 1.9 and 6.3 years, and a shorter survival time after diagnosis than in AD. The difference in survival between AD and DLB could be because DLB is harder to diagnose, and may be diagnosed later in the course of the disease.[191] The US National Institute of Neurological Disorders and Stroke writes that people with DLB typically live 8 years following diagnosis, about the same as AD,[4] though some people with Lewy body dementias live for 20 years.[2] Shorter life expectancy is more likely when visual hallucinations, abnormal gait, and variable cognition are present early on.[171] In the late part of the disease, people may be unable to care for themselves.[21] Falls—caused by many factors including parkinsonism, dysautonomia, and frailness—increase morbidity and mortality.[59] Aspiration pneumonia, a complication of difficulty in swallowing that results from dysautonomia, commonly causes death among people with the Lewy body dementias.[83] Following pneumonia, cardiovascular disease and sepsis are common causes of death.[18]

Epidemiology

The Lewy body dementias are as a group the second most common form of neurodegenerative dementia after AD as of 2020.[147] DLB itself is one of the three most common types of dementia, along with AD and vascular dementia.[2][192][lower-alpha 5]

The diagnostic criteria for DLB before 2017 were highly specific, but not very sensitive,[193] so that more than half of cases were missed historically.[170] Dementia with Lewy bodies was under-recognized as of 2015, and there was little data on its epidemiology.[141] The incidence and prevalence of DLB are not known accurately, but estimates are increasing with better recognition of the condition since 2017.[12][13]

About 0.4% of those over the age 65 are affected with DLB,[8] and between 1 and 4 per 1,000 people develop the condition each year.[194][195] Symptoms usually appear between the ages of 50 and 80,[8] (median 76[3]) and it is not uncommon for it to be diagnosed before the age of 65.[141] DLB is thought to be slightly more common in men than women,[3] but a 2014 review challenged that view, and said that the gender distribution was unclear.[196] An estimated 10 to 15% of diagnosed dementias are Lewy body type, but estimates range as high as 23%[141] for those in clinical studies.[18]

A French study found an incidence among persons 65 years and older almost four times higher than a US study (32 US vs 112 France per 100,000 person-years), but the US study may have excluded people with only mild or no parkinsonism, while the French study screened for parkinsonism.[141] Neither of the studies assessed systematically for RBD, so DLB may have been underdiagnosed in both studies.[141] A door-to-door study in Japan found a prevalence of 0.53% for persons 65 and older, and a Spanish study found similar results.[197]

History

Frederic Lewy (1885–1950) was the first to discover the abnormal protein deposits in the early 1900s.[198][199] In 1912, studying Parkinson's disease (paralysis agitans),[200] he described findings of these inclusions in the vagus nerve, the nucleus basalis of Meynert and other brain regions.[18][201] He published a book, The Study on Muscle Tone and Movement. Including Systematic Investigations on the Clinic, Physiology, Pathology, and Pathogenesis of Paralysis agitans, in 1923 and except for one brief paper a year later, never mentioned his findings again.[202]

In 1961, Okazaki et al. published an account of diffuse Lewy-type inclusions associated with dementia in two autopsied cases.[198][203] Dementia with Lewy bodies was fully described in an autopsied case by Japanese psychiatrist and neuropathologist Kenji Kosaka in 1976.[204][205] Kosaka first proposed the term Lewy body disease four years later, based on 20 autopsied cases.[43][203] DLB was thought to be rare until it became easier to diagnose in the 1980s after the discovery of alpha-synuclein immunostaining that highlighted Lewy bodies in post mortem brains.[198] Kosaka et al. described thirty-four more cases in 1984, which were mentioned along with four UK cases by Gibb et al. in 1987 in the journal Brain, bringing attention of the Japanese work to the Western world.[206] A year later, Burkhardt et al. published the first general description of diffuse Lewy body disease.[207]

With Japanese, UK, and US researchers finding in the 1990s that DLB was a common dementia, there were nonetheless no diagnostic guidelines, and each group was using different terminology.[208] The different groups of researchers began to realize that a collaborative approach was needed if research was to advance.[209] The DLB Consortium was established, and in 1996, the term dementia with Lewy bodies was agreed upon[17] and the first criteria for diagnosing DLB were elaborated.[43]

Two 1997 discoveries highlighted the importance of Lewy body inclusions in neurodegenerative processes: a mutation in the SNCA gene that encodes the alpha-synuclein protein was found in kindreds with Parkinson's disease, and Lewy bodies and neurites were found to be immunoreactive for alpha-synuclein.[210] Thus, alpha-synuclein aggregation as the primary building block of the synucleinopathies was established.[210]

Between 1995 and 2005, the DLB Consortium issued three Consensus Reports on DLB.[211] DLB was included in the fourth text revision of the DSM (DSM-IV-TR, published in 2000) under "Dementia due to other general medical conditions”. In the 2010s, the possibility of a genetic basis began to emerge.[92] The Fourth Consensus Report was issued in 2017, giving increased diagnostic weighting to RBD and 123I-MIBG myocardial scintigraphy.[115]

Society and culture

See caption.
His widow said Robin Williams (shown in 2011) was diagnosed during autopsy as having diffuse Lewy bodies.[212][213][214]

The British author and poet Mervyn Peake died in 1968 and was diagnosed posthumously as a probable case of DLB in a 2003 study published in JAMA Neurology.[215] Based on signs in his work and letters of progressive deterioration, fluctuating cognitive decline, deterioration in visuospatial function, declining attention span, and visual hallucinations and delusions, his may be the earliest known case where DLB was found to have been the likely cause of death.[215]

Robin Williams, the American actor and comedian, died by suicide on August 11, 2014. He had been diagnosed with Parkinson's disease,[212] and according to his widow had experienced depression, anxiety and increasing paranoia.[213] His widow said that his autopsy found diffuse Lewy body disease,[212][213][214] while the autopsy used the term diffuse Lewy body dementia.[216] Dennis Dickson, a spokesperson for the Lewy Body Dementia Association, clarified the distinction by stating that diffuse Lewy body dementia is more commonly called diffuse Lewy body disease and refers to the underlying disease process.[216] According to Dickson, "Lewy bodies are generally limited in distribution, but in DLB, the Lewy bodies are spread widely throughout the brain, as was the case with Robin Williams."[216] Ian G. McKeith, professor and researcher of Lewy body dementias, commented that Williams' symptoms and autopsy findings were explained by DLB.[217]

Research directions

Cognitive training, deep brain stimulation and transcranial direct-current stimulation have been studied more in Parkinson's and Alzheimer's disease than they have in dementia with Lewy bodies, and all are potential therapies for DLB.[218] As of 2019, clinical trials for several drugs are underway. Trials for the antipsychotic pimavanserin for individuals with DLB are ongoing,[24] but it has a risk of cardiac side effects and increased mortality.[40] The anticonvulsant zonisamide is approved in Japan for treating Parkinson's disease and is in clinical trials for treating parkinsonism symptoms in DLB.[40]

The identification of biomarkers for DLB will enable treatments to begin sooner[218] and improve the ability to select subjects and measure efficacy in clinical trials.[219] As of 2019, the diagnosis of DLB is made using the DLB Consortium criteria, but a 2017 study of skin samples from 18 people with DLB found that all of them had deposits of phosphorylated alpha-synuclein, while none of the controls did, suggesting that skin samples are a potential biomarker.[220]

Strategies for future intervention involve modifying the course of the disease using immunotherapy, gene therapy, and stem cell therapy, and reducing amyloid beta or alpha-synuclein accumulation. Therapies under study as of 2019 aim to reduce brain levels of alpha-synuclein (with the pharmaceuticals ambroxol, NPT200-11, and E2027) or to use immunotherapy to reduce widespread neuroinflammation resulting from alpha-synuclein deposits.[221][218]

Notes

  1. 1.0 1.1 Areas of the brain and functions affected:[21] Also affected are the hypothalamus, spinal cord and peripheral nervous system—autonomic dysfunction.[100]
  2. The European Federation of Neurological Societies–European Neurological Society and the British Association for Psychopharmacology also have diagnostic guidelines, but they were not developed specifically for DLB, hence the DLB Consortium guidelines are the most widely used and cited.[119]
  3. Questionnaires such as the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), the REM Sleep Behavior Questionnaires – Hong-Kong (RBD-HK), the Mayo Sleep Questionnaire (MSQ), the Innsbruck REM Sleep Behavior Disorder Inventory, and the REM Sleep Behavior Disorder Single-Question Screen are well-validated.[53]
  4. "The use of antipsychotics ... comes with attendant mortality risks ... and they should be avoided whenever possible, given the increased risk of a serious sensitivity reaction."[23] Citing McKeith et al (1992): "Severe, and often fatal, neuroleptic sensitivity may occur [such as] ... exaggerated adverse responses to standard doses ... [and] development or worsening of extrapyramidal features ... or acute and severe physical deterioration".[150]
  5. Kosaka (2017) writes: "Dementia with Lewy bodies (DLB) is now well known to be the second most frequent dementia following Alzheimer disease (AD). Of all types of dementia, AD is known to account for about 50%, DLB about 20% and vascular dementia (VD) about 15%. Thus, AD, DLB, and VD are now considered to be the three major dementias."[192] The NINDS (2020) says that Lewy body dementia "is one of the most common causes of dementia, after Alzheimer’s disease and vascular disease."[2] Hershey (2019) says, "DLB is the third most common of all the neurodegenerative diseases behind both Alzheimer's disease and Parkinson's disease".[3]

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Works cited

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External resources