|Other names: Bradyarrhythmia, brachycardia|
|Sinus bradycardia seen in lead II with a heart rate of about 50BPM|
|Symptoms||None, tiredness, confusion, chest pain, syncope, heart failure|
|Types||Sinus bradycardia, sick sinus syndrome, AV block|
|Causes||Physically fit, low oxygen, heart attack, low thyroid, AV block, high blood potassium, toxicity due to beta blockers, calcium channel blockers, or digoxin|
|Diagnostic method||Electrocardiogram (ECG)|
|Treatment||Atropine, cardiac pacing, infusions of dopamine or epinephrine|
Bradycardia is defined as a heart rate of under 60 beats per minute (BPM) in adults, though symptoms generally only result when the heart rate is under 50. Mild symptoms may include tiredness and shortness of breath with exercise. Severe symptoms may include confusion, chest pain, syncope, and heart failure.
Bradycardia may be normal, such as in those who are physically fit, older in age, or during an autonomic response. It may also occur due to a number of health problems such as low oxygen, heart attack, low thyroid, AV block, high blood potassium, and toxicity due to beta blockers, calcium channel blockers, and digoxin. Diagnosis is by an electrocardiogram (ECG). The term "relative bradycardia" refer to a heart rate that, although not below 60 BPM, is considered too slow for the current medical condition.
In those with symptoms atropine may be used. Other measures may include cardiac pacing, either transcutaneous pacing or transvenous pacing, or infusions of the medications dopamine or epinephrine. Bradycardia is common. Bradycardia was described by Hippocrates before 370 BC.
Atrial bradycardias are divided into three types. The first, respiratory sinus arrhythmia, is usually found in young and healthy adults. Heart rate increases during inhalation and decreases during exhalation. This is thought to be caused by changes in the vagal tone during respiration. If the decrease during exhalation drops the heart rate below 60 BPM on each breath, this type of bradycardia is usually deemed benign and a sign of good autonomic tone.
The second, sinus bradycardia, is a sinus rhythm of less than 60 BPM. It is a common condition found in both healthy individuals and those considered well-conditioned athletes. Studies have found that 50–85% of conditioned athletes have benign sinus bradycardia, as compared to 23% of the general population studied. The heart muscle of athletes has become conditioned to have a higher stroke volume, so requires fewer contractions to circulate the same volume of blood. During sleep, a slow heartbeat down to rates around 30–35 BPM is common, and is considered normal. Trained athletes may also have athletic heart syndrome, a very slow resting heart rate that occurs as a sport adaptation and helps prevent tachycardia during training.
The third, sick sinus syndrome, covers conditions that include severe sinus bradycardia, sinoatrial block, sinus arrest, and bradycardia-tachycardia syndrome (atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia).
An AV-junctional rhythm, or atrioventricular nodal bradycardia, is usually caused by the absence of the electrical impulse from the sinus node. This usually appears on an electrocardiogram (EKG) with a normal QRS complex accompanied with an inverted P wave either before, during, or after the QRS complex.
An AV-junctional escape beat is a delayed heartbeat originating from an ectopic focus somewhere in the AV junction. It occurs when the rate of depolarization of the SA node falls below the rate of the AV node. This dysrhythmia also may occur when the electrical impulses from the SA node fail to reach the AV node because of SA or AV block. This is a protective mechanism for the heart, to compensate for an SA node that is no longer handling the pacemaking activity, and is one of a series of backup sites that can take over pacemaker function when the SA node fails to do so. This would present with a longer PR interval. An AV-junctional escape complex is a normal response that may result from excessive vagal tone on the SA node. Pathological causes include sinus bradycardia, sinus arrest, sinus exit block, or AV block.
Idioventricular rhythm, also known as atrioventricular bradycardia or ventricular escape rhythm, is a heart rate of less than 50 BPM. This is a safety mechanism when a lack of electrical impulse or stimuli from the atrium occurs. Impulses originating within or below the bundle of His in the AV node will produce a wide QRS complex with heart rates between 20 and 40 BPM. Those above the bundle of His, also known as junctional, will typically range between 40 and 60 BPM with a narrow QRS complex. In a third-degree heart block, about 61% take place at the bundle branch-Purkinje system, 21% at the AV node, and 15% at the bundle of His. AV block may be ruled out with an EKG indicating "a 1:1 relationship between P waves and QRS complexes." Ventricular bradycardias occurs with sinus bradycardia, sinus arrest, and AV block. Treatment often consists of the administration of atropine and cardiac pacing.
For infants, bradycardia is defined as a heart rate less than 100 BPM (normal is around 120–160 BPM) . Premature babies are more likely than full-term babies to have apnea and bradycardia spells; their cause is not clearly understood. The spells may be related to centers inside the brain that regulate breathing which may not be fully developed. Touching the baby gently or rocking the incubator slightly will almost always get the baby to start breathing again, which increases the heart rate. Medications (theophylline or caffeine) can be used to treat these spells in babies if necessary. Neonatal intensive-care unit (NICU) standard practice is to electronically monitor the heart and lungs for this reason.
This arrhythmia can be underlain by several causes, which are best divided into cardiac and non-cardiac causes. Non-cardiac causes are usually secondary, and can involve recreational drug use or abuse; metabolic or endocrine issues, especially hypothyroidism; an electrolyte imbalance; neurologic factors; autonomic reflexes; situational factors such as prolonged bed rest; and autoimmunity.
Cardiac causes include acute or chronic ischemic heart disease, vascular heart disease, valvular heart disease, or degenerative primary electrical disease. Ultimately, the causes act by three mechanisms: depressed automaticity of the heart, conduction block, or escape pacemakers and rhythms.
In general, two types of problems result in bradycardias: disorders of the SA node, and disorders of the AV node.
With SA node dysfunction (sometimes called sick sinus syndrome), there may be disordered automaticity or impaired conduction of the impulse from the SA node into the surrounding atrial tissue (an "exit block"). Second-degree sinoatrial blocks can be detected only by use of a 12-lead EKG. It is difficult and sometimes impossible to assign a mechanism to any particular bradycardia, but the underlying mechanism is not clinically relevant to treatment, which is the same in both cases of sick sinus syndrome: a permanent pacemaker.
AV conduction disturbances (AV block; primary AV block, secondary type I AV block, secondary type II AV block, tertiary AV block) may result from impaired conduction in the AV node, or anywhere below it, such as in the bundle of His. The clinical relevance pertaining to AV blocks is greater than that of SA blocks.
Beta blocker medicines also can slow the heart rate and decrease how forcefully the heart contracts. Beta blockers may slow the heart rate to a dangerous level if prescribed with calcium channel blocker-type medications.
Bradycardia in an adult is any heart rate less than 60 beats per minute (BPM), although symptoms usually manifest only for heart rates less than 50 BPM. This is determined usually either by palpation or EKG. If symptoms occur, a determination of electrolytes may be helpful in determining the underlying cause.
Emergency treatment is not needed if the person is asymptomatic or minimally symptomatic.
If a person is unstable, the initial recommended treatment is intravenous atropine. Doses less than 0.5 mg should not be used, as this may further decrease the rate. If this is not effective, intravenous inotrope infusion (dopamine, epinephrine) or transcutaneous pacing should be used. Transvenous pacing may be required if the cause of the bradycardia is not rapidly reversible.
Society and culture
- Daniel Green holds the world record for the slowest heartbeat in a healthy human, with a heart rate measured in 2014 of 26 BPM.
- Martin Brady holds the Guinness world record for the slowest heart rate with a certified rate over a minute duration of 27 BPM.
- Professional cyclist Miguel Indurain had, during his career, a resting heart rate of 28 BPM.
- Neumar RW, Otto CW, Link MS, et al. (November 2010). "Part 8: adult advanced cardiovascular life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care". Circulation. 122 (18 Suppl 3): S729–67. doi:10.1161/CIRCULATIONAHA.110.970988. PMID 20956224.
- Mangrum, JM; DiMarco, JP (9 March 2000). "The evaluation and management of bradycardia". The New England journal of medicine. 342 (10): 703–9. doi:10.1056/NEJM200003093421006. PMID 10706901.
- "Overview of Arrhythmias - Cardiovascular Disorders". Merck Manuals Professional Edition. Retrieved 27 December 2020.
- "Types of Arrhythmia". 1 July 2011. Archived from the original on 7 June 2015. Retrieved 19 March 2015.
- Sidhu, S; Marine, JE (July 2020). "Evaluating and managing bradycardia". Trends in cardiovascular medicine. 30 (5): 265–272. doi:10.1016/j.tcm.2019.07.001. PMID 31311698.
- Ye, F; Hatahet, M; Youniss, MA; Toklu, HZ; Mazza, JJ; Yale, S (June 2018). "The Clinical Significance of Relative Bradycardia". WMJ : official publication of the State Medical Society of Wisconsin. 117 (2): 73–78. PMID 30048576.
- Katz, Arnold M. (2010). Physiology of the Heart. Lippincott Williams & Wilkins. p. 431. ISBN 978-1-60831-171-2.
- Allan B. Wolfson, ed. (2005). Harwood-Nuss' Clinical Practice of Emergency Medicine (4th ed.). p. 260. ISBN 978-0-7817-5125-4.
- Ward, Bryan G.; Rippe, J.M. (1992). "11". Athletic Heart Syndrome. Clinical Sports Medicine. p. 259.
- Baggish, Aaron L.; Wood, Malissa J. (14 June 2011). "Athlete's heart and cardiovascular care of the athlete: scientific and clinical update". Circulation. 123 (23): 2723–2735. doi:10.1161/CIRCULATIONAHA.110.981571. ISSN 1524-4539. PMID 21670241.
- "AV Junctional Rhythm Disturbances (for Professionals)". American Heart Association. 4 December 2008. Retrieved 15 December 2009.
- "Arrhythmias and Conduction Disorders". The merck Manuals: Online Medical Library. Merck Sharp and Dohme Corp. January 2008. Retrieved 16 December 2009.
- Adams MG, Pelter MM (September 2003). "Ventricular escape rhythms". American Journal of Critical Care. 12 (5): 477–8. doi:10.4037/ajcc2003.12.5.477. PMID 14503433.
- Ye, Fan; Hatahet, Mohamad; Youniss, Mohamed A.; Toklu, Hale Z.; Mazza, Joseph J.; Yale, Steven (June 2018). "The Clinical Significance of Relative Bradycardia". WMJ. 117 (2): 73–78. ISSN 1098-1861. PMID 30048576.
- Ufberg, JW; Clark, JS (February 2006). "Bradydysrhythmias and atrioventricular conduction blocks". Emerg. Med. Clin. North Am. 24 (1): 1–9, v. doi:10.1016/j.emc.2005.08.006. PMID 16308110.
- Michael Panneton, W. (2013). "The Mammalian Diving Response: An Enigmatic Reflex to Preserve Life?". Physiology. 28 (5): 284–297. doi:10.1152/physiol.00020.2013. ISSN 1548-9213. PMC 3768097. PMID 23997188.
- de Caen, AR; Berg, MD; Chameides, L; Gooden, CK; Hickey, RW; Scott, HF; Sutton, RM; Tijssen, JA; Topjian, A; van der Jagt, ÉW; Schexnayder, SM; Samson, RA (3 November 2015). "Part 12: Pediatric Advanced Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care". Circulation. 132 (18 Suppl 2): S526–42. doi:10.1161/cir.0000000000000266. PMC 6191296. PMID 26473000.
- Atkins, DL; Berger, S; Duff, JP; Gonzales, JC; Hunt, EA; Joyner, BL; Meaney, PA; Niles, DE; Samson, RA; Schexnayder, SM (3 November 2015). "Part 11: Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care". Circulation. 132 (18 Suppl 2): S519–25. doi:10.1161/cir.0000000000000265. PMID 26472999.
- Yechiam Ostchega; et al. (24 August 2011). "Resting Pulse Rate Reference Data for Children, Adolescents, and Adults: United States, 1999–2008" (PDF). National Health Statistics Reports. Centers for Disease Control. Retrieved 15 December 2018.
- Prutchi, David (2005). Design and Development of Medical Electronic Instrumentation. John Wiley & Sons. p. 371. ISBN 9780471681830.
- "Slowest heart rate: Daniel Green breaks Guinness World Records record". World Record Academy. 29 November 2014. Retrieved 5 August 2015.
- "Lowest heart rate". Guinness World Records. Retrieved 5 August 2015.
- Lovgren, Stefan (20 August 2004). "Olympic Gold Begins With Good Genes, Experts Say". National Geographic News. Retrieved 8 September 2014.