Torsades de pointes

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Torsades de pointes
Other names: Torsade de pointes, torsades
12-lead ECG of torsades de pointes (TdP) in a person with low blood potassium (2.4 mmol/L) and low blood magnesium (1.6 mg/dL)
SymptomsNone, palpitations, lightheadedness, syncope[1]
ComplicationsVentricular fibrillation, sudden cardiac death[1]
Risk factorsQT prolongation, low potassium, low magnesium, low calcium, low heart rate, heart disease[1]
Diagnostic methodelectrocardiogram (ECG)[1]
Differential diagnosisVentricular tachycardia, ventricular fibrillation[1]
PreventionStopping certain medications, correcting electrolytes[1]
TreatmentIntravenous magnesium, electrical cardioversion, defibrillation[1]

Torsades de pointes (TdP) is a specific type of abnormal heart rhythm.[1] In about half of cases there are no symptoms while many of the rest have palpitations, lightheadedness, or syncope.[1] In up to 10% of cases there is ventricular fibrillation and sudden cardiac death.[1]

Risk factors include QT prolongation, low potassium, low magnesium, low calcium, low heart rate, and heart disease.[1] QT prolongation can be either inherited or occur from medication such as antiarrhythmics, antipsychotics, antiemetics, antifungals, or antibiotics.[1] Genetic conditions that cause QT prolongation include Jervell and Lange-Nielsen syndrome and Romano-Ward syndrome.[1] Diagnosis is by an electrocardiogram (ECG) showing polymorphic ventricular tachycardia with gradually changing height of the QRS complexes.[1]

Prevention involves avoiding medications that result in QT prolongation and correcting electrolytes.[1] Many episodes end without any specific treatment.[1] Intravenous magnesium at a dose of 2 grams injected slowly into a vein is often recommended.[1] In those with low blood pressure but a pulse electrical cardioversion at 50 to 100J is recommended.[1] If no pulse is present defibrillation is recommended.[1] Other options may include isoproterenol or overdrive pacing to speed up the heart rate.[1]

TdP is rare.[1] About 1 in a million people are estimated to get TdP due to medications a year in Europe.[1] Women are more often affected than men as are those over the age of 65.[1] It was described by French physician François Dessertenne in 1966.[2][3] The term is from the French "twisting of points".[3]

Signs and symptoms

Most episodes will revert spontaneously to a normal sinus rhythm.[4] Symptoms and consequences include palpitations, dizziness, lightheadedness (during shorter episodes), fainting (during longer episodes), and sudden cardiac death.


Torsades occurs as both an inherited (linked to at least 17 genes)[5] and as an acquired form caused most often by drugs and/or electrolyte disorders that cause excessive lengthening of the QT interval.[6]

Common causes for torsades de pointes include drug-induced QT prolongation and less often diarrhea, low serum magnesium, and low serum potassium or congenital long QT syndrome. It can be seen in malnourished individuals and chronic alcoholics, due to a deficiency in potassium and/or magnesium. Certain drugs and combinations of drugs resulting in drug interactions are common contributors to torsades de pointes risk. QT-prolonging medications such as clarithromycin, levofloxacin, or haloperidol, when taken concurrently with cytochrome P450 inhibitors, such as fluoxetine, cimetidine, or particular foods including grapefruit, can result in higher-than-normal levels of medications that prolong the QT interval in the bloodstream and therefore increase a person's risk of developing torsades de pointes. At least one mention of the common over-the-counter medication loperamide causing TdP has been made in the literature, although the dose preceding this particular cardiac event was well beyond the therapeutic range of the medication.[7] In addition, patients with inherited long QT syndrome have a very high risk of episodes of TdP and that risk can be further increased by drugs and electrolyte disorders that further prolong QT.


TdP may occur in people taking certain prescription drugs has been both a major liability and reason for removal of 14 medications from the marketplace.[8] Forty nine drugs known to cause TdP and another 170 that are known to prolong QTc remain on the market because the drugs provide medical benefit and the risk of TdP can be managed and mitigated by instructions in the drug label.[9][10] Examples of compounds linked to clinical observations of TdP include amiodarone, most fluoroquinolones, methadone, lithium, chloroquine, erythromycin, azithromycin, pimozide, and phenothiazines.[11] The anti-emetic agent ondansetron may also increase the risk of developing TdP.[12] It has also been shown as a side effect of certain anti-arrhythmic medications, such as sotalol, procainamide, quinidine, ibutilide, and dofetilide[13] In one example, the gastrokinetic drug cisapride (Propulsid) was withdrawn from the US market in 2000 after it was linked to deaths caused by long QT syndrome-induced torsades de pointes. This effect can be directly linked to QT prolongation mediated predominantly by inhibition of the hERG channel and, in some cases, augmentation of the late sodium channel.[14]

Risk factors

Lead II ECG showing a TdP patient being shocked by an implantable cardioverter-defibrillator back to their baseline cardiac rhythm

The following is a partial list of factors associated with an increased tendency towards developing torsades de pointes:[15]


Action potential of cardiac muscles can be broken down into five phases:

  • Phase 0: Sodium channels open, resulting in the entrance of Na+ into the cells; this results in the depolarization of the cardiac muscles.
  • Phase 1: Sodium channels close; this stops depolarization. Potassium channels open, leading to an outward current of K+ out of the cells.
  • Phase 2: Potassium channels remain open (outward current of K+), and calcium channels now also open (inward current of Ca++), resulting in a plateau state.
  • Phase 3: Calcium channels close (inward Ca++ stops), but potassium channels are still open (outward K+ current); this persists until the cells gain back normal polarization (repolarization achieved). Please note that phase 0 leads to a net gain of Na+, while phases 1-3 lead to a net loss of K+. This imbalance is corrected by the Na+/K+-ATPase channel that pumps K+ into the cell and sodium out of the cell; this does not change polarization of the cells, but does restore ionic content to its initial state.
  • Phase 4: Exciting triggers (e.g. sinus node) will cause minor depolarization in the cells; this will result in increasing permeability of sodium channels, which trigger the opening of sodium channels.

Repolarization of the cardiomyocytes occurs in phases 1-3, and is caused predominantly by the outward movement of potassium ions. In Torsades de pointes, however, the repolarization is prolonged; this can be due to electrolyte disturbances (hypokalemia, hypomagnesemia, hypocalcemia), bradycardia, certain drugs (disopyramide, sotalol, amiodarone, amitriptyline, chlorpromazine, erythromycin) and/or congenital syndromes.[16]

The prolongation of repolarisation may result in subsequent activation of an inward depolarisation current, known as an early after-depolarisation, which may promote triggered activity.[17] Re-entry, due to a dispersion of refractory periods, is also possible;[18] this is because M Cells (found in the mid myocardial layer) show a more prolonged repolarization phase in response to potassium blockage than other cells. In turn, this produces a zone of functional refractoriness (inability to depolarize) in the mid myocardial layer.[17] When new action potential is generated, the mid myocardial layer will remain in a refractory period, but the surrounding tissue will depolarize. As soon as the mid myocardial layer is no longer in a refractory period, excitation from nearby tissue will cause a retrograde current and a reentry circuit that will result in a positive chronotropic cycle, leading to tachycardia.


The ECG tracing in torsades demonstrates a polymorphic ventricular tachycardia with a characteristic illusion of a twisting of the QRS complex around the isoelectric baseline (peaks, which are at first pointing up, appear to be pointing down for subsequent "beats" when looking at ECG traces of the "heartbeat"). It is hemodynamically unstable and causes a sudden drop in arterial blood pressure, leading to dizziness and fainting. Depending on their cause, most individual episodes of torsades de pointes revert to normal sinus rhythm within a few seconds; however, episodes may also persist and possibly degenerate into ventricular fibrillation, leading to sudden death in the absence of prompt medical intervention. Torsades de pointes is associated with long QT syndrome, a condition whereby prolonged QT intervals are visible on an ECG. Long QT intervals predispose the patient to an R-on-T phenomenon, wherein the R-wave, representing ventricular depolarization, occurs during the relative refractory period at the end of repolarization (represented by the latter half of the T-wave). An R-on-T can initiate torsades. Sometimes, pathologic T-U waves may be seen in the ECG before the initiation of torsades.[19]

A "short-coupled variant of torsade de pointes", which presents without long QT syndrome, was also described in 1994 as having the following characteristics:[20]

  • Drastic rotation of the heart's electrical axis
  • Prolonged QT interval (LQTS) - may not be present in the short-coupled variant of torsade de pointes
  • Preceded by long and short RR-intervals - not present in the short-coupled variant of torsade de pointes
  • Triggered by a premature ventricular contraction (R-on-T PVC)


The treatment of torsades de pointes aims to restore a normal rhythm and to prevent the arrhythmia recurring. While torsades may spontaneously revert to a normal sinus rhythm, sustained torsades requires emergency treatment to prevent cardiac arrest.[21] The most effective treatment to terminate torsades is an electrical cardioversion - a procedure in which an electrical current is applied across the heart to temporarily stop and then resynchronise the heart's cells.[21] Treatment to prevent recurrent torsades includes infusion of magnesium sulphate,[22] correction of electrolyte imbalances such as low blood potassium levels (hypokalaemia), and withdrawal of any medications that prolong the QT interval. Treatments used to prevent torsades in specific circumstances include beta blockers or mexiletine in long QT syndrome.[23] Occasionally a pacemaker may be used to accelerate the heart's own sinus rhythm, and those at risk of further torsades may be offered an implantable defibrillator to automatically detect and defibrillate further episodes of the arrhythmia.[23]


The phenomenon was originally described in a French medical journal by Dessertenne in 1966, when he observed this cardiac rhythm disorder in an 80-year-old female patient with complete intermittent atrioventricular block. In coining the term, he referred his colleagues to the "Dictionnaire Le Robert", a bilingual French English dictionary, of which his wife had just given him a copy. Here, "torsade" is defined as:

  • a bundle of threads, twisted in a helix or spiral, for ornamental purposes (such as in an Aran sweater);
  • long hair twisted together;
  • an ornamental motif, as seen on architectural columns.


The singular and plural forms (torsade de pointes and torsades de pointes) have both often been used. The question of whether either one is grammatically "correct" and the other "incorrect" has repeatedly arisen. This is seen among major medical dictionaries, where one enters only the plural form, another enters the plural form as the headword but lists the singular as a variant, and yet another enters the singular form as the headword and gives a usage comment saying that the plural is not preferred. One group of physicians has suggested[24] that it would make the most sense to use the singular form to refer to the arrhythmia entity (where an arrhythmia may involve one or multiple episodes), and that one might best reserve the plural form for describing repeated twisting during a single episode. Regarding the natural language variation, they concluded, in good nature, "Wasn't it the French who coined the term vive la difference?"[24]


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  2. Dessertenne, F. (1966). Prepared by Rahel Farhad. "La tachycardie ventriculaire a deux foyers opposes variables". Archives des maladies du coeur et des vaisseaux (in French). 59 (2): 263–272. ISSN 0003-9683. PMID 4956181.{{cite journal}}: CS1 maint: unrecognized language (link)
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