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Trade namesEfflumidex, Flucon, FML Forte, others
Other namesFluorometholone acetate
  • (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[,7.011,15]heptadeca-3,6-dien-5-one
Clinical data
Drug classCorticosteroid (glucocorticoid)[1][2]
Main usesAllergic conjunctivitis, anterior uveitis[1][3]
Side effectsIncreased eye pressure, blurry vision, eye irritation, change in taste[1]
  • C
External links
Chemical and physical data
Molar mass376.468 g·mol−1
3D model (JSmol)
  • O=C(C)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](C)C[C@H]4[C@@H]2CC3)C)C
  • InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 checkY

Fluorometholone, sold under the brand names Efflumidex among others, is a steroid used to treat inflammatory eye diseases such as allergic conjunctivitis and anterior uveitis.[1][3] It is used as an eye drop.[4]

Common side effects include increased eye pressure, blurry vision, eye irritation, and change in taste.[1] Other side effects may include cataracts and eye infection.[4] It is a corticosteroid, specifically a glucocorticoid.[1][2] It comes in two main forms fluorometholone and fluorometholone acetate.[1]

Fluorometholone was patented in 1959.[2] It is available as a generic medication.[5] In the United Kingdom 10 ml of solution costs the NHS about £3 as of 2021.[4] This amount in the United States costs about 42 USD.[5]

Medical uses


It is applied every hour for the first 1 to 2 days and than two to four times per day.[4]

Side effects

It should generally not be used in people with viral infections of the eye, especially without an antiviral.[3]

Pregnancy and breastfeeding

Use during breastfeeding is not believed to be of concern.[6]


Chemically it is known under the name 6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione, (6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one.

See also


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "Fluorometholone Monograph for Professionals". Drugs.com. Archived from the original on 31 July 2020. Retrieved 14 December 2021.
  2. 2.0 2.1 2.2 Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 566–. ISBN 978-1-4757-2085-3. Archived from the original on 1 August 2020. Retrieved 3 October 2021.
  3. 3.0 3.1 3.2 "FML Ophthalmic Ointment (fluorometholone) dose, indications, adverse effects, interactions... from PDR.net". www.pdr.net. Archived from the original on 28 September 2018. Retrieved 14 December 2021.
  4. 4.0 4.1 4.2 4.3 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1208. ISBN 978-0857114105.
  5. 5.0 5.1 "Fluorometholone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 14 December 2021.
  6. "Fluorometholone". Drugs and Lactation Database (LactMed). National Library of Medicine (US). 2006. Archived from the original on 15 December 2021. Retrieved 14 December 2021.

External links