Amlodipine/benazepril

From WikiProjectMed
Jump to navigation Jump to search
Amlodipine/benazepril
Amlodipine.svg
Benazepril.svg
Combination of
AmlodipineCalcium channel blocker
BenazeprilACE inhibitor
Names
Trade namesLotrel
Clinical data
Pregnancy
category
  • US: D (Evidence of risk)
Routes of
use
By mouth
External links
AHFS/Drugs.comProfessional Drug Facts
Legal
License data
Legal status
 ☒N☑Y (what is this?)  (verify)

Amlodipine/benazepril, marketed as Lotrel among others, is a medication used to treat high blood pressure.[1] It is a combination of amlodipine, a calcium channel blocker and benazepril, an angiotensin converting enzyme inhibitor.[1] It may be used if a single agent is not sufficient.[1] It is taken by mouth.[1]

Common side effects include cough, dizziness, and swelling.[1] Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure.[1] Use in pregnancy is not recommended.[1] Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.[1]

The combination was approved for medical use in the United States in 1995.[2] It is available as a generic medication.[3] A month supply in the United States has a wholesale cost of about US$4.50.[4] In 2017, it was the 160th most commonly prescribed medication in the United States, with more than three million prescriptions.[5][6]

Medical use

It is used to treat high blood pressure.[1] It is not a first line treatment.[7]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Amlodipine besylate and benazepril hydrochloride- amlodipine besylate and benazepril hydrochloride capsule". DailyMed. U.S. National Library of Medicine. Retrieved 10 March 2019.
  2. Cerner Multum. "Amlodipine and benazepril Uses, Side Effects & Warnings". Drugs.com. Retrieved 10 March 2019.
  3. Bope ET, Kellerman RD (2016). Conn's Current Therapy 2017 E-Book. Elsevier Health Sciences. p. 124. ISBN 978-0-323-44335-7.
  4. "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
  5. "The Top 300 of 2020". ClinCalc DrugStats Database. ClinCalc LLC. Retrieved 11 April 2020.
  6. "Amlodipine Besylate; Benazepril Hydrochloride - Drug Usage Statistics". ClinCalc DrugStats Database. ClinCalc LLC. Retrieved 11 April 2020.
  7. Faulkner MA, Hilleman DE (January 2001). "Amlodipine/benazepril: fixed dose combination therapy for hypertension". Expert Opinion on Pharmacotherapy. 2 (1): 165–78. doi:10.1517/14656566.2.1.165. PMID 11336577. S2CID 23021242.

External links

Identifiers: