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Combination of
TelmisartanAngiotensin II receptor antagonist
AmlodipineCalcium channel blocker
Trade namesTwynsta, others
Clinical data
Routes of
By mouth
Defined daily dosenot established[1]
Legal status
  • In general: ℞ (Prescription only)

Telmisartan/amlodipine, sold under the brand name Twynsta among others, is a medication used to treat high blood pressure.[2] It is a combination of telmisartan an angiotensin II receptor antagonist with amlodipine a calcium channel blocker.[2] It is taken by mouth.[2]

Common side effects include dizziness, swelling, and back pain.[2] Severe side effects may include low blood pressure, kidney problems, electrolyte problems, and a heart attack.[2] Use during pregnancy may harm the baby.[2] Telmisartan works by blocking the effects of angiotensin II while amlodipine works by decreasing calcium ion entry into smooth muscle and heart muscle.[2]

The combination was approved for medical use in the United States in 2009.[2] The combination is on the World Health Organization's List of Essential Medicines.[3] It is available as a generic medication.[4] In the United States it costs at least US$57 per month as of 2019.[5]


The defined daily dose is not established.[1]


  1. 1.0 1.1 "WHOCC - ATC/DDD Index". Archived from the original on 1 July 2021. Retrieved 10 September 2020.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 "DailyMed - TELMISARTAN AND AMLODIPINE tablet". Archived from the original on 28 February 2020. Retrieved 30 October 2019.
  3. "World Health Organization model list of essential medicines: 21st list 2019". 2019. hdl:10665/325771. {{cite journal}}: Cite journal requires |journal= (help)
  4. "Telmisartan and Amlodipine (Professional Patient Advice)". Archived from the original on 30 October 2019. Retrieved 30 October 2019.
  5. "Amlodipine/telmisartan Prices, Coupons & Patient Assistance Programs". Archived from the original on 30 October 2019. Retrieved 30 October 2019.

External links