|Trade names||Accupril, others|
|Defined daily dose||15 mg|
|Elimination half-life||2 hours|
|Chemical and physical data|
|Molar mass||438.524 g·mol−1|
|3D model (JSmol)|
|Melting point||120 to 130 °C (248 to 266 °F)|
Quinapril, sold under the brand name Accupril among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It is a reasonable initial treatment for high blood pressure. It is taken by mouth.
Common side effects include headaches, dizziness, feeling tired, and cough. Serious side effects may include liver problems, low blood pressure, angioedema, kidney problems, and high blood potassium. Use in pregnancy and breastfeeding is not recommended. It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.
Quinapril was patented in 1980 and came into medical use in 1989. It is available as a generic medication. A month supply of the defined daily dose of 15mg in the United Kingdom costs the NHS less than £20 as of 2020. In the United States a month supply of this dose costs about US$7. In 2017, it was the 269th most commonly prescribed medication in the United States, with more than one million prescriptions.
Quinapril is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure.
Side effects of quinapril include back pain, increased risk of infection,difficulty sleeping, upset stomach, dizziness, cough, vomiting, angioedema and fatigue. A swollen and inflamed tongue is a rare side effect.
- Pregnancy and first few weeks after delivery if breastfeeding.
- If used when there is impaired kidney function then the dose of quinapril may need to be less.
- If used when there is impaired liver function, caution needs to be taken if the person is also taking a diuretic.
- People with a history of angioedema related to previous treatment with an ACE inhibitor.
- Hypersensitivity to quinapril
Mechanism of action
Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood.
Society and culture
A month supply of the DDD of 15mg/day in the United Kingdom costs the NHS around £17 as of 2020. In the United States a month supply of this dose costs about US$7. In 2017, it was the 269th most commonly prescribed medication in the United States, with more than one million prescriptions.
- "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 7 September 2020. CS1 maint: discouraged parameter (link)
- "Quinapril Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019. CS1 maint: discouraged parameter (link)
- "Quinapril Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019. CS1 maint: discouraged parameter (link)
- Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 9783527607495.
- BNF (80 ed.). London: BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. pp. 183–184. ISBN 978-0-85711-369-6.CS1 maint: date format (link)
- "Quinapril Prices, Coupons & Savings Tips". GoodRx. Retrieved 18 March 2021. CS1 maint: discouraged parameter (link)
- "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
- "Quinapril - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.