|Trade names||Avapro, others|
|Drug class||Angiotensin II receptor antagonist (ARB)|
|Main uses||High blood pressure, heart failure, diabetic kidney disease|
|Side effects||Dizziness, diarrhea, feeling tired, muscle pain, heartburn|
|Defined daily dose||150 mg|
|Bioavailability||60% to 80%|
|Elimination half-life||11 h to 15 h|
|Excretion||Kidney 20%, feces 65%|
|Chemical and physical data|
|Molar mass||428.540 g·mol−1|
|3D model (JSmol)|
Irbesartan, sold under the brand name Avapro among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It is a reasonable initial treatment for high blood pressure. It is taken by mouth. Versions are available as the combination irbesartan/hydrochlorothiazide.
Common side effects include dizziness, diarrhea, feeling tired, muscle pain, and heartburn. Serious side effects may include kidney problems, low blood pressure, and angioedema. Use in pregnancy may harm the baby and use when breastfeeding is not recommended. It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.
Irbesartan was patented in 1990, and approved for medical use in 1997. It is available as a generic medication. A month supply in the United Kingdom costs the NHS less than two pounds as of 2019. In the United States the wholesale cost of this amount is about six dollars. In 2017, it was the 220th most commonly prescribed medication in the United States, with more than two million prescriptions.
As with all angiotensin II receptor antagonists, irbesartan is used for the treatment of high blood pressure. It may also delay progression of diabetic nephropathy and the reduction of kidney disease progression in type 2 diabetes, hypertension and microalbuminuria (>30 mg/24 h) or proteinuria (>900 mg/24 h).
Irbesartan is also available in a combination formulation with a low-dose thiazide diuretic, invariably hydrochlorothiazide, to achieve an additive antihypertensive effect. Irbesartan/hydrochlorothiazide combination preparations are marketed under various brand names.
Society and culture
A month supply in the United Kingdom costs the NHS less than two pounds as of 2019. In the United States the wholesale cost of this amount is about six dollars.In 2017, it was the 220th most commonly prescribed medication in the United States, with more than two million prescriptions.
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