Dexbrompheniramine

Dexbrompheniramine

Names
Trade names	Drixoril, Conex, Dixaphedrine
Other names	Dexbrompheniramine maleate
IUPAC name (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
Clinical data
Pregnancy category	US: C (Risk not ruled out)
Routes of use	Oral
External links
AHFS/Drugs.com	Multum Consumer Information
Legal
Legal status	CA: OTC US: OTC
Pharmacokinetics
Elimination half-life	25 hours
Chemical and physical data
Formula	C16H19BrN2
Molar mass	319.246 g·mol−1
3D model (JSmol)	Interactive image
SMILES Brc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C
InChI InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1 Y Key:ZDIGNSYAACHWNL-HNNXBMFYSA-N Y

Dexbrompheniramine is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in combination with pseudoephedrine under the name Drixoral in the US and Canada. It is an alkylamine antihistamine.

Dexbrompheniramine is a first generation antihistamine that reduces the effects of the neurotransmitter histamine in the body; sneezing, itching, watery eyes, and runny nose.

Society and culture

Cost

This medication in the U.S. is $19.93 (USD) for 30 tablets of 2 mg

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  DexbrompheniramineMaleate costs (US)

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  DexbrompheniramineMaleate prescriptions (US)

Interactions

• MAO inhibitors within 14 days. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

• Potassium

• Drinking alcohol can increase side effects of dexbrompheniramine.

External links

Identifiers:	ATC code: R06AB06 (WHO) CAS Number: 132-21-8 Y PubChem CID: 16960 IUPHAR/BPS: 7588 DrugBank: DB00405 Y ChemSpider: 16068 Y UNII: 75T64B71RP ChEBI: CHEBI:59269 ChEMBL: ChEMBL1201287 N