Dexbrompheniramine

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Dexbrompheniramine
Dexbrompheniramine.svg
Names
Trade namesDrixoril, Conex, Dixaphedrine
Other namesDexbrompheniramine maleate
  • (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
use
Oral
External links
AHFS/Drugs.comMultum Consumer Information
Legal
Legal status
Pharmacokinetics
Elimination half-life25 hours
Chemical and physical data
FormulaC16H19BrN2
Molar mass319.246 g·mol−1
3D model (JSmol)
  • Brc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C
  • InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1 checkY
  • Key:ZDIGNSYAACHWNL-HNNXBMFYSA-N checkY

Dexbrompheniramine is an antihistamine with anticholinergic properties[1] used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in combination with pseudoephedrine under the name Drixoral in the US and Canada. It is an alkylamine antihistamine.

Dexbrompheniramine is a first generation antihistamine that reduces the effects of the neurotransmitter histamine in the body; sneezing, itching, watery eyes, and runny nose.

Society and culture

Cost

This medication in the U.S. is $19.93 (USD) for 30 tablets of 2 mg[2]

Interactions

  • MAO inhibitors within 14 days. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
  • Potassium
  • Drinking alcohol can increase side effects of dexbrompheniramine.

References

  1. Löfkvist T (1978). "A comparative evaluation of oral decongestants in the treatment of vasomotor rhinitis". The Journal of International Medical Research. 6 (1): 56–60. doi:10.1177/030006057800600110. PMID 627306. S2CID 39205584.
  2. "Dexbrompheniramine Maleate prices and discount coupons | America's Pharmacy". www.americaspharmacy.com. Archived from the original on 28 August 2021. Retrieved 27 March 2021.

External links

Identifiers: