|Trade names||Axid, Tazac, others|
|Drug class||H2 antagonist|
|Main uses||Stomach ulcers, gastroesophageal reflux disease|
|Side effects||Headache, dizziness|
|Typical dose||75 to 300 mg/day|
|Elimination half-life||1–2 hours|
|Chemical and physical data|
|Molar mass||331.45 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Common side effects include headache and dizziness. Other side effects may include pneumonia. No harm has been found in pregnancy, but such use has not been well studied. Use when breastfeeding appears safe. It is a histamine H2 receptor antagonist that inhibits stomach acid production.
Nizatidine was patented in 1980 and approved for medical use in 1987. It was approved in the United States in 1988. It is available as a generic medication and over the counter. In the United Kingdom a month of medication costs the NHS about £18 as of 2021. In the United States this costs about 20 USD.
It is used at a dose of 75 to 150 mg by mouth once or twice per day.
Side effects are uncommon, usually minor, and include diarrhea, constipation, fatigue, drowsiness, headache, and muscle aches.
Nizatidine was developed by Eli Lilly, and was first marketed in the United States in 1988. It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole ring in place of the furan ring in ranitidine. In September 2000, Eli Lilly announced they would sell the sales and marketing rights for Axid to Reliant Pharmaceuticals. Subsequently, Reliant developed the oral solution of Axid, marketing this in 2004, after gaining approval from the U.S. Food and Drug Administration (FDA). However, a year later, they sold rights of the Axid Oral Solution (including the issued patent protecting the product) to Braintree Laboratories.
Axid (nizatidine) drug recalled due to presence of NDMA
- Famotidine (Pepcid) — another H2 receptor antagonist
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