|Trade names||Pin-X, Combantrin, others|
|Main uses||Parasitic worm infections|
|Side effects||Nausea, headache, dizziness, trouble sleeping|
|Defined daily dose||0.75 gram.|
|Typical dose||10 mg/kg once per day|
|Chemical and physical data|
|Molar mass||206.31 g·mol−1|
|3D model (JSmol)|
|Melting point||178 to 179 °C (352 to 354 °F)|
Pyrantel is a medication used to treat a number of parasitic worm infections. This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis. It is taken by mouth.
Side effects include nausea, headache, dizziness, trouble sleeping, and rash. A lower dose should be used in people with liver disease. While it does not appear to be harmful during pregnancy, it has not been studied for this use. It is unclear if it is safe for use during breastfeeding. It is in the antihelmintic family of medications. It works by paralyzing worms.
Pyrantel was initially described in 1965. It is on the World Health Organization's List of Essential Medicines. Pyrantel is available as a generic medication. It costs less than US$25 per course of treatment in the United States. It may also be used to treat worms in a number of other animals.
The defined daily dose is 0.75 gram (by mouth). It is typically used as 10 mg/kg. A single dose is all that is required for ascariasis while a second dose is given after two to four weeks for pin worms. For trichinellosis it is given once per day for five days.
Pregnancy and breastfeeding
Mechanism of action
Pyrantel pamoate acts as a depolarizing neuromuscular blocking agent, thereby causing sudden contraction, followed by paralysis, of the helminths. This has the result of causing the worm to "lose its grip" on the intestinal wall and be passed out of the system by natural process. Since Pyrantel is poorly absorbed by the host's intestine, the host is unaffected by the small dosage of medication used. Spastic (tetanic) paralyzing agents, in particular pyrantel pamoate, may induce complete intestinal obstruction in a heavy worm load. This obstruction is usually in the form of a worm impaction and happens when a very small, but heavily parasitized animal is treated and tries to pass a large number of dislodged worms at once. Worms usually pass in normal stool or with diarrhea, straining, and occasional vomiting.
There are a number of brands, including "Reese's Pinworm Medicine", "Pin-X", "Pin-Rid","PYRANTRIN", "COMBANTRIN", "Anthel", "Helmintox", "Helmex", "Strongid" and Drontal Cat.
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