Nosebleed

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Nosebleed
Other names: Epistaxis, bloody nose, nasal hemorrhage[1]
Young child with nosebleed, smiling cropped.jpg
A three-year-old child with a minor nosebleed from falling and hitting his face on the floor.
Pronunciation
SpecialtyOtorhinolaryngology
SymptomsBleeding from the nose[1]
Usual onsetLess than 10 and over 50 years old[2]
Risk factorsTrauma, blood thinners, high blood pressure, alcoholism, seasonal allergies, dry weather[3]
Diagnostic methodDirect observation[1]
Differential diagnosisBleeding from the lungs, esophageal varices[1]
PreventionPetroleum jelly in the nose[4]
TreatmentPressure over the front half of the nose, nasal packing, endoscopy[5]
MedicationTranexamic acid[6]
Frequency60% at some point in time[7]
DeathsRare[3]

A nosebleed, also known as epistaxis, is bleeding from the nose.[1] Blood can also flow down into the stomach and cause nausea and vomiting.[8] In more severe cases blood may come out of both nostrils.[9] Rarely bleeding may be so significant low blood pressure occurs.[1] Rarely the blood can come up the nasolacrimal duct and out from the eye.[10]

Risk factors include trauma including putting the finger in the nose, blood thinners, high blood pressure, alcoholism, seasonal allergies, dry weather, and inhaled corticosteroids.[3] There are two types: anterior, which is more common; and posterior, which is less common but more serious.[3] Anterior nosebleeds generally occur from Kiesselbach's plexus while posterior bleeds generally occur from the sphenopalatine artery.[3] The diagnosis is by direct observation.[1]

Prevention may include the use of petroleum jelly in the nose.[4] Initially treatment is generally by applying pressure for at least five minutes over the front half of the nose.[5] If this is not sufficient nasal packing may be used.[5] Tranexamic acid may also be helpful.[6] If bleeding episodes continue endoscopy is recommended.[5]

About 60% of people have a nosebleed at some point in their life.[7] About 10% of nosebleeds are serious.[7] Nosebleeds are rarely fatal, accounting for only 4 of the 2.4 million deaths in the U.S. in 1999.[11] Nosebleeds most commonly affect those younger than 10 and older than 50.[2]

Cause

Two children boxing, the one on the right having a nosebleed due to a punch to the face.

Nosebleeds can occur due to a variety of reasons. Some of the most common causes include trauma from nose picking, blunt trauma (such as a motor vehicle accident), or insertion of a foreign object (more likely in children).[4] Relative humidity (including centrally heated buildings), respiratory tract infections, chronic sinusitis, rhinitis or environmental irritants can cause inflammation and thinning of the tissue in the nose, leading to a greater likelihood of bleeding from the nose.[4]

Most causes are self-limiting and do not require medical attention. However, if nosebleeds are recurrent or do not respond to home therapies, an underlying cause may need to be investigated. A more extensive list of causes are below:[2][4][12]

Traumatic

Coagulopathy

Inflammatory

Medications/Drugs

Neoplastic

Vascular

Dietary

Pathophysiology

Type of nosebleeds[3]
Anterior Posterior
Usual location Kiesselbach's plexus Sphenopalatine artery
Frequency Common Rare
Features Directly seen Both nostrils
Initial measures fail
Nasal packing 5.5 cm 7.5 cm
The arteries that supply Kiesselbach's plexus (responsible for anterior nosebleeds)

The nasal mucosa contains a rich blood supply that can be easily ruptured and cause bleeding. Rupture may be spontaneous or initiated by trauma. An increase in blood pressure (e.g. due to general hypertension) tends to increase the duration of spontaneous epistaxis.[13] Anticoagulant medication and disorders of blood clotting can promote and prolong bleeding. Spontaneous epistaxis is more common in the elderly as the nasal mucosa (lining) becomes dry and thin and blood pressure tends to be higher. The elderly are also more prone to prolonged nosebleeds as their blood vessels are less able to constrict and control the bleeding.

The vast majority of nosebleeds occur in the anterior (front) part of the nose from the nasal septum. This area is richly endowed with small blood vessels (Kiesselbach's plexus). This region is also known as Little's area. Bleeding farther back in the nose is known as a posterior bleed and is usually due to bleeding from Woodruff's plexus, a venous plexus situated in the posterior part of inferior meatus.[14] Posterior bleeds are often prolonged and difficult to control. They can be associated with bleeding from both nostrils and with a greater flow of blood into the mouth.[15]

Sometimes blood flowing from other sources of bleeding passes through the nasal cavity and exits the nostrils. It is thus blood coming from the nose but is not a true nosebleed, that is, not truly originating from the nasal cavity. Such bleeding is called "pseudoepistaxis" (pseudo + epistaxis). Examples include blood coughed up through the airway and ending up in the nasal cavity, then dripping out.

Prevention

People with uncomplicated nosebleeds can use conservative methods to prevent future nosebleeds such as sleeping in a humidified environment or applying petroleum jelly to the nasal nares.[4]

Treatment

Most anterior nosebleeds can be stopped by applying direct pressure, which helps by promoting blood clots.[4] Those who have a nosebleed should first attempt to blow out any blood clots and then apply pressure for at least five minutes and up to 20 minutes.[4] Pressure should be firm and tilting the head forward helps decrease the chance of nausea and airway obstruction.[15] When attempting to stop a nosebleed at home, the head should not be tilted back.[2] Swallowing excess blood can irritate the stomach and cause vomiting. Vasoconstrictive medications such as oxymetazoline or phenylephrine are widely available over the counter for treatment of allergic rhinitis and may also be used to control minor nosebleeds.[16] Those with nosebleeds that last longer than 20 minutes, despite direct pressure, should seek medical attention.[4]

Nasal packing

If pressure and chemical cauterization cannot stop bleeding, nasal packing is the mainstay of treatment.[17] There are several forms of packing.[18] Traditionally, packing was accomplished by placing gauze into the nose, thereby placing pressure on the vessels in the nose and stopping the bleeding.

Traditional gauze packing has been replaced with products such as Merocel and the Rapid Rhino.[17] The Merocel nasal tampon is similar to gauze packing except it is a foam polymer which expands in the nose and provides a less hospitable medium for bacteria.[4] The Rapid Rhino stops nosebleeds using a balloon catheter, which has a cuff that is inflated by air to stop bleeding through extra pressure in the nasal cavity.[17] Reviews have found the efficacy is similar between the two; however, the Rapid Rhino has been shown to have greater ease of insertion and reduced discomfort.[17] People who receive nasal packing need to return in 24–72 hours in order to have packing removed.[4][3] There are also several dissolvable packing materials that stop bleeding through use of thrombotic agents that promote blood clots, such as surgicel.[4] The thrombogenic foams and gels do not require removal and dissolve after a few days. Posterior nasal packing can be achieved by using a Foley catheter, blowing up the balloon when it is in the back of the throat, and applying traction.[18]

Complications of nasal packing include abscesses, septal hematomas, sinusitis, and pressure necrosis.[2] In rare cases toxic shock syndrome can occur with prolonged nasal packing. Some use topical antibiotic ointment on nasal packing.[2] The routine use of antibiotics to prevent infection in those who have anterior packing placed appears to not be necessary.[19]

Tranexamic acid

Tranexamic acid helps promote blood clotting.[6] For nosebleeds it can be applied to the site of bleeding, taken by mouth, or injected into a vein.[6]

Cauterization

This method involves applying a chemical such as silver nitrate to the nasal mucosa, which burns and seals off the bleeding.[12] Eventually the nasal tissue to which the chemical is applied will undergo necrosis.[12] This form of treatment is best for mild bleeds, especially in children, that are clearly visible.[12] A topical anesthetic (such as lidocaine) is usually applied prior to cauterization. Silver nitrate can cause blackening of the skin due to silver sulfide deposit, though this will fade with time.[20]

Surgery

Ongoing bleeding despite good nasal packing is a surgical emergency and can be treated by endoscopic evaluation of the nasal cavity under general anesthesia to identify an elusive bleeding point or to directly ligate (tie off) the blood vessels supplying the nose. These blood vessels include the sphenopalatine, anterior and posterior ethmoidal arteries. More rarely the maxillary or a branch of the external carotid artery can be ligated. The bleeding can also be stopped by intra-arterial embolization using a catheter placed in the groin and threaded up the aorta to the bleeding vessel by an interventional radiologist.[21] There is no difference in outcomes between embolization and ligation as treatment options, but embolization is considerably more expensive.[22] Continued bleeding may be an indication of more serious underlying conditions.[21]

Other

The utility of local cooling of the head and neck is controversial.[23] Some state that applying ice to the nose or forehead is not useful.[24][25] Others feel that it may promote vasoconstriction of the nasal blood vessels and thus be useful.[26]

Epidemiology

Nosebleeds are reported in up to 60% of the population with peak incidences in those under the age of ten and over the age of 50 and appear to occur in males more than females.[15]

Society and culture

In the visual language of Japanese manga and anime, a sudden, violent nosebleed indicates that the bleeding person is sexually aroused.[27][28] In Western fiction, nosebleeds often signify intense mental focus or effort, particularly during the use of psychic powers.[29][30]

In American and Canadian usage, "nosebleed section" or "nosebleed seats" are common slang for seating at sporting or other spectator events that are the highest up and farthest away from the event. The reference alludes to the propensity for nasal hemorrhage at high altitudes, usually owing to lower barometric pressure.

The oral history of the Native American Sioux tribe includes reference to women who experience nosebleeds as a result of a lover's playing of music, implying sexual arousal.[31]

In Finnish language, "picking blood from one's nose" and "begging for a nosebleed" are commonly used in abstract meaning to describe self-destructive behaviour, for example ignoring safety procedures or deliberately aggravating stronger parties.[32]

In Filipino slang, to "have a nosebleed" is to have serious difficulty conversing in English with a fluent or native English speaker. It can also refer to anxiety brought on by a stressful event such as an examination or a job interview.[33]

In the Dutch language, "pretending to have a nosebleed" is a saying that means pretending not to know anything about something.[34]

Etymology

The word epistaxis is from Greek: ἐπιστάζω epistazo, "to bleed from the nose" from ἐπί epi, "above, over" and στάζω stazo, "to drip [from the nostrils]".

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Ferri, Fred F. (2013). Ferri's Clinical Advisor 2014 E-Book: 5 Books in 1. Elsevier Health Sciences. p. 399. ISBN 978-0-323-08431-4. Archived from the original on 2021-08-28. Retrieved 2020-04-13.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Kucik, Corry J.; Clenney, Timothy (2005-01-15). "Management of epistaxis". American Family Physician. 71 (2): 305–311. ISSN 0002-838X. PMID 15686301.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Tabassom, A; Cho, JJ (January 2020). "Epistaxis (Nose Bleed)". StatPearls. PMID 28613768.
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  5. 5.0 5.1 5.2 5.3 Tunkel, David E.; Anne, Samantha; Payne, Spencer C.; Ishman, Stacey L.; Rosenfeld, Richard M.; Abramson, Peter J.; Alikhaani, Jacqueline D.; Benoit, Margo McKenna; Bercovitz, Rachel S.; Brown, Michael D.; Chernobilsky, Boris; Feldstein, David A.; Hackell, Jesse M.; Holbrook, Eric H.; Holdsworth, Sarah M.; Lin, Kenneth W.; Lind, Meredith Merz; Poetker, David M.; Riley, Charles A.; Schneider, John S.; Seidman, Michael D.; Vadlamudi, Venu; Valdez, Tulio A.; Nnacheta, Lorraine C.; Monjur, Taskin M. (7 January 2020). "Clinical Practice Guideline: Nosebleed (Epistaxis) Executive Summary". Otolaryngology–Head and Neck Surgery. 162 (1): 8–25. doi:10.1177/0194599819889955. PMID 31910122.
  6. 6.0 6.1 6.2 6.3 Joseph, Jonathan; Martinez-Devesa, Pablo; Bellorini, Jenny; Burton, Martin J (2018-12-31). Cochrane ENT Group (ed.). "Tranexamic acid for patients with nasal haemorrhage (epistaxis)". Cochrane Database of Systematic Reviews. 12: CD004328. doi:10.1002/14651858.CD004328.pub3. PMC 6517002. PMID 30596479.
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  14. The Journal of Laryngology & Otology (2008), 122: 1074–1077
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  19. Tran, Quincy K.; Rehan, Meboob A.; Haase, Daniel J.; Matta, Ann; Pourmand, Ali (May 2020). "Prophylactic antibiotics for anterior nasal packing in emergency department: A systematic review and meta-analysis of clinically-significant infections". The American Journal of Emergency Medicine. 38 (5): 983–989. doi:10.1016/j.ajem.2019.11.037.
  20. Béquignon, E.; Teissier, N.; Gauthier, A.; Brugel, L.; Kermadec, H. De; Coste, A.; Prulière-Escabasse, V. (2017-08-01). "Emergency Department care of childhood epistaxis". Emerg Med J. 34 (8): 543–548. doi:10.1136/emermed-2015-205528. ISSN 1472-0205. PMID 27542804. Archived from the original on 2018-11-01. Retrieved 2018-11-01.
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  24. al.], edited by Roger Jones ... [et (2004). Oxford textbook of primary medical care (repr. ed.). Oxford: Oxford University Press. p. 711. ISBN 9780198567820. Archived from the original on 2017-07-12. Retrieved 2016-05-10.
  25. Bissonnette, Bruno (2010). Pediatric Anesthesia. New York: McGraw-Hill Medical. p. 1182. ISBN 9781607950936.
  26. al.], A.Y. Elzouki ... [et (2011-10-29). Textbook of clinical pediatrics (2nd ed.). Berlin: Springer. p. 3968. ISBN 9783642022012.
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  29. Tracey, Liz (30 August 2016). ""Stranger Things" and the Psychic Nosebleed". JSTOR Daily. Archived from the original on 6 November 2016. Retrieved 6 November 2016.
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  31. Various (1984). Erdoes, Richard; Ortiz, Alfonso (eds.). American Indian Myths and Legends (2 ed.). Toronto, Ontario: Random House of Canada Limited. p. 274.
  32. "Finnish idioms and proverbs". saaressa.blogspot.fr. Archived from the original on 2017-12-22. Retrieved 2017-12-19.
  33. OMG! Nosebleed! Say what?! Archived 2013-10-20 at the Wayback Machine Retrieved 28 August 2013
  34. "Doen alsof je neus bloedt". OnzeTaal. Archived from the original on 8 June 2020. Retrieved 8 June 2020.

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External resources