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Combination of
LoratadineH1 antagonist
Trade namesClaritin-D, Clarinase
Clinical data
  • US: B (No risk in non-human studies)
Routes of
External links
Legal status

Pseudoephedrine/loratadine (trade name Claritin-D, Clarinase) is an orally administered combination drug used for the treatment of allergic rhinitis and the common cold[1][2]. This drug can be bought "over the counter" in some countries (United States, Hong Kong), but it is restricted to prescription in others (Czech Republic, Israel).

Medical uses

Pseudoephedrine/loratadine are indicated for the relief of symptoms associated with allergic rhinitis and the common cold including nasal congestion, sneezing, rhinorrhea, pruritus and lacrimation.


Clarinase Repetabs

A Clarinase Repetab tablet contains 5 mg loratadine in the tablet coating and 120 mg pseudoephedrine sulfate equally distributed between the tablet coating and the barrier-coated core. The two active components in the coating are quickly liberated; release of pseudoephedrine in the core is delayed for several hours.

Interactions, adverse effects and contraindications

Interactions, adverse effects and contraindications are described in more detail in the articles about pseudoephedrine and loratadine.


When sympathomimetics are given to patients receiving monoamine oxidase inhibitors (MAO inhibitors), hypertensive reactions, including hypertensive crises may occur.

Side effects

During controlled clinical studies with the recommended dosage, the incidence of adverse effects was comparable to that of placebo, with the exception of insomnia and dry mouth, both of which were commonly reported.


Clarinase is contraindicated in patients receiving MAO inhibitor therapy or within 14 days of discontinuing such treatment and in patients with narrow angle glaucoma, urinary retention, severe hypertension, severe coronary artery disease and hyperthyroidism.

Society and culture


This medication has a cost in the U.S. of $15 (USD) for 10 tablets, extended release 10 mg-240 mg[3]


  1. "Clarinase repetabs" (PDF). Ministry of Health Il. Archived (PDF) from the original on 29 August 2021. Retrieved 3 April 2021.
  2. "Claritin-D: Uses, Dosage, Side Effects". Archived from the original on 9 March 2021. Retrieved 3 April 2021.
  3. "Loratadine/pseudoephedrine Prices, Coupons & Patient Assistance Programs". Archived from the original on 15 January 2021. Retrieved 3 April 2021.

External links