|Trade names||Synalar, Iluvien, others|
|Other names||Fluocinolone acetonide|
|Drug class||Corticosteroid (glucocorticoid)|
|Main uses||Skin: Eczema, psoriasis|
Eye: Uveitis, diabetic macular edema
|Side effects||Skin: Irritation, dry skin, folliculitis, acne, decreased pigmentation, skin atrophy, infection|
Eye: Increased eye pressure, eye pain, conjunctival bleeding, blurry vision, dry eyes
|Elimination half-life||1.3 to 1.7 hours|
|Chemical and physical data|
|Molar mass||452.495 g·mol−1|
|3D model (JSmol)|
Fluocinolone, sold under the brand name Synalar among others, is a corticosteroid. It is applied to the skin to treat eczema and psoriasis. It is used as an implant within the eye to treat uveitis and vision problems due to diabetic macular edema.
When applied to the skin common side effects include irritation, dry skin, folliculitis, acne, decreased pigmentation, skin atrophy, and infection. When used in the eye common side effects include increased eye pressure, eye pain, conjunctival bleeding, blurry vision, and dry eyes. Other complications may include cataracts, retinal detachment, and infection in the eye. It works by decreasing inflammation.
Fluocinolone was first made in 1959. It was approved for medical use in 1961. In the United Kingdom it costs the NHS about £10 for a tube of 60 grams and about £5,500 for a dose to place in the eye as of 2021. This amount in the United States costs about 30 USD and 9,200 USD respectively.
Fluocinolone acetonide intravitreal implants have been used to treat non-infectious uveitis. A systematic review could not determine whether fluocinolone acetonide implants are superior to standard of care treatment for uveitis.
The cream can be mild to strong depending on the concentration.
It may be given by injection into the eye of 190 micrograms.
Fluocinolone is a group V (0.025%) or group VI (0.01%) corticosteroid under US classification.
Society and culture
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