|Trade names||Analpram, Fleet Pain-Relief, Itch-X, Preparation H, others|
|Other names||Pramoxine, pramoxine HCI|
|Main uses||Pain, itching|
|Side effects||Burning at the site of application|
|Topical, rectal, Vaginal|
|Chemical and physical data|
|Molar mass||293.407 g·mol−1|
|3D model (JSmol)|
Pramocaine, also known as pramoxine, is a medication used to improve pain and itching such as occurs in hemorrhoids or insect bites. It is applied to the skin. There are versions that come mixed with corticosteroids.
Common side effects include burning at the site of application. Other side effects may include allergic reactions, though it is generally safe even if someone has reactions to other local anesthetics. It works by stabilizing the cell membrane of neurons.
Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. The popular itch creams Gold Bond and some forms of calamine lotion use pramocaine hydrochloride to numb sensitive skin, as does the pain relief variant of Neosporin and some formulations of Sarna. The hydrochloride salt form of pramocaine is water-soluble.
During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent.
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- "Pramoxine". MedlinePlus Drug Information. National Library of Medicine. September 25, 2013. Archived from the original on April 20, 2015. Retrieved October 9, 2013.