Prednicarbate

From WikiProjectMed
Jump to navigation Jump to search
Prednicarbate
Prednicarbate.png
Names
Trade namesDermatop, others
Other names{2-[(8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl} propanoate
  • 17-[(Ethoxycarbonyl)oxy]-11β-hydroxy-3,20-dioxopregna-1,4-dien-21-yl propionate
Clinical data
Drug classCorticosteroid
Main usesAtopic dermatitis, psoriasis, allergic contact dermatitis[1]
Side effectsBurning, irritation, thinning of the skin, acne, loss of pigmentation, striae, telangiectasia[1]
Routes of
use
Topical
External links
AHFS/Drugs.comMonograph
US NLMPrednicarbate
MedlinePlusa604021
Chemical and physical data
FormulaC27H36O8
Molar mass488.577 g·mol−1
3D model (JSmol)
  • O=C(OCC(=O)[C@@]1(OC(=O)OCC)CC[C@H]2[C@H]4[C@H]([C@@H](O)C[C@]12C)[C@]/3(/C=C\C(=O)\C=C\3CC4)C)CC
  • InChI=1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1 ☒N
  • Key:FNPXMHRZILFCKX-KAJVQRHHSA-N ☒N

Prednicarbate, sold under the brand name Dermatop among others, is a corticosteroid that is used to treat skin conditions such as atopic dermatitis, psoriasis, and allergic contact dermatitis.[1] It is applied to the skin.[1]

Common side effects include burning, irritation, thinning of the skin, acne, loss of pigmentation, striae, and telangiectasia.[1] Other side effects may include skin infection, allergic reactions, and Cushing's syndrome.[1] It is considered to be a medium strength steroid.[1]

Prednicarbate was approved for medical use in the United States in 1991.[1] It is available as a generic medication.[2] A 60 gram tube in the United States costs about 34 USD as of 2021.[2]

Medical uses

Dosage

It is applied to the affected area twice per day at a 0.1% strength.[1]

Chemistry

It is nonhalogenated.[3]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Prednicarbate Monograph for Professionals". Drugs.com. Archived from the original on 26 September 2020. Retrieved 29 October 2021.
  2. 2.0 2.1 "Prednicarbate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 10 June 2016. Retrieved 29 October 2021.
  3. Gupta AK, Chow M (2004). "A review of prednicarbate (Dermatop)". Skin Therapy Lett. 9 (10): 5–6, 9. PMID 15657633. Archived from the original on 2018-01-09. Retrieved 2021-04-15.

External links

Identifiers: