|Drug class||Nonionic detergent|
|Main uses||Varicose veins|
|Side effects||Local reaction, anaphylaxis, blood clots, tissue necrosis|
|Injection into a vein|
|Chemical and physical data|
|Molar mass||582.816 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Polidocanol, sold under the brand name Asclera, is a medication used to treat varicose veins including spider veins and reticular veins. It may also be used for hemangiomas, and vascular malformations. It is given by injection into the vein as part of sclerotherapy.
The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue. Polidocanol in the form of Varithena injected in the greater saphenous vein can cause the eruption of varicose and spider veins throughout the lower leg. This procedure should be done with caution and with the knowledge that the appearance of the leg may be forever compromised.
- "Polidocanol Monograph for Professionals". Drugs.com. Retrieved 28 October 2021.
- "DailyMed - ASCLERA- polidocanol injection, solution". dailymed.nlm.nih.gov. Retrieved 28 October 2021.
- Gao Z, Zhang Y, Li W, Shi C (January 2018). "Effectiveness and safety of polidocanol for the treatment of hemangiomas and vascular malformations: A meta-analysis". Dermatologic Therapy. 31 (1). doi:10.1111/dth.12568. PMID 29082587.
- "Asclera Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 28 October 2021.
- "ADDENDUM to the SCCP opinion on polidocanol (SCCP/1130/07)" (PDF). Retrieved 28 October 2021.
- Star P, Connor DE, Parsi K (April 2018). "Novel developments in foam sclerotherapy: Focus on Varithena® (polidocanol endovenous microfoam) in the management of varicose veins". Phlebology. 33 (3): 150–162. doi:10.1177/0268355516687864. PMID 28166694.
- Facts and Companies: Varicose Vein Treatment Approved
- "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.
- Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
- "Varithena™ (polidocanol injectable foam) For Intravenous Use. Full Prescribing Information" (PDF). Biocompatibles, Inc. Archived from the original (PDF) on 4 August 2016. Retrieved 1 October 2015.