Diflorasone diacetate

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Diflorasone diacetate
Names
Trade namesPsorcon, Florone, others
  • [17-(2-Acetyloxyacetyl)- 6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] acetate
Clinical data
Drug classTopical steroid[1]
Main usesAtopic dermatitis, psoriasis, allergic contact dermatitis[1]
Side effectsIrritation, folliculitis, acne, decreased pigmentation, perioral dermatitis, infection, increased hair, striae[1]
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
use		Topical
External links
AHFS/Drugs.comMonograph
MedlinePlusa602019
Legal
License data
Legal status
Chemical and physical data
FormulaC26H32F2O7
Molar mass494.532 g·mol−1
  • InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1 checkY
  • Key:BOBLHFUVNSFZPJ-JOYXJVLSSA-N checkY

Diflorasone diacetate, sold under the brand name Psorcon among others, is a topical steroid.[1] It is used for atopic dermatitis, psoriasis, and allergic contact dermatitis.[1]

Common side effects include irritation, folliculitis, acne, decreased pigmentation, perioral dermatitis, infection, increased hair, and striae.[1] Other side effects may include Cushing's syndrome and allergic reactions.[1] Safety in pregnancy is unclear.[1] The strength in the United States is classified as group III.[2]

Diflorasone diacetate was approved for medical use in the United States in 1977.[1] It is available as a generic medication.[3] In the United States a 30 gram tube costs about 65 USD as of 2021.[3]

Medical uses

Dosage

It may be used once to four times per day.[1]

Side effects

No long-term animal studies have been done to determine whether diflorasone diacetate could have carcinogenic properties.[citation needed]

Little data is available regarding whether diflorasone diacetate would be present in great enough quantities to cause harm to a infant.[4]

Society and culture

It is manufactured by E. Fougera & Co.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 "Diflorasone Monograph for Professionals". Drugs.com. Archived from the original on 19 January 2021. Retrieved 28 December 2021.
  2. ↑ "Topical Corticosteroids: Overview". 9 July 2021. Archived from the original on 19 August 2021. Retrieved 28 December 2021.
  3. ↑ 3.0 3.1 "Diflorasone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 12 May 2016. Retrieved 28 December 2021.
  4. ↑ "Diflorasone topical". Drugs.com. Archived from the original on 2020-11-17. Retrieved 2020-11-12.

External links

Identifiers:
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