|Other names||Alclometasone dipropionate|
|Main uses||Atopic dermatitis, psoriasis, allergic contact dermatitis|
|Side effects||Redness, irritation, acne, skin thinning, striae|
|Onset of action||Eczema: 5.3 - 13.9 days; Psoriasis: 6.7 - 14.8 days |
|Bioavailability||3% systemically (topical)|
|Chemical and physical data|
|Molar mass||408.92 g·mol−1|
|3D model (JSmol)|
Alclometasone, sold under the brand name Aclovate among others, is a corticosteroid used for certain skin conditions. This includes atopic dermatitis, psoriasis, and allergic contact dermatitis. It is applied to the skin.
Common side effects include redness, irritation, acne, skin thinning, and striae. Other side effects may include Cushing’s syndrome and infection. Safety in pregnancy is unclear. It is of moderate strength.
Alclometasone was approved for medical use in the United States in 1982. It is available as a generic medication. In the United States 15 grams costs about 12 USD as of 2022. In the United Kingdom 50 grams costs the NHS about £13.
Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:
- atopic dermatitis
- allergic dermatitis
- contact dermatitis
- actinic dermatitis
- kiss-type allergy
- skin itch
Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.
It is applied as 0.05% once to two per day.
- hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
- cutaneous tuberculosis
- chicken pox
- perioral dermatitis
- open wounds
- trophic ulcers
- viral infection of skin
- skin manifestations of syphilis
Adverse reactions (sometimes, less than 1-2% cases) include:
- skin reddening
- skin irritation
- prickly heat
- white atrophy
- reinfection of skin
Alclometasone induces the production of lipocortins, formally known as annexins, which inhibit phospholipase A2 – the enzyme responsible for the synthesis of arachidonic acid. Without the oxidation of arachidonic acid, eicosanoids, such as prostaglandins, thromboxanes, and leukotrienes, can't be produced.
Society and culture
Alclometasone as Aclovate is supplied in:
- Cream; Topical; 0.05%
- Ointment; Topical; 0.05%
- BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1286. ISBN 978-0857114105.
- "Alclometasone Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 13 January 2022.
- "Alclometasone - Professional Patient Advice". Drugs.com. Archived from the original on 28 August 2019. Retrieved 29 December 2017.
- "Alclometasone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 7 November 2016. Retrieved 13 January 2022.