|Trade names||Adreson, Cortison, Cortisone, Cortisone Acetate, Cortone, Cortistab, Cortisyl, others|
|Other names||Cortisone 21-acetate; 17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-acetate|
|Drug class||Corticosteroid (glucocorticoid, mineralocorticoid)|
|Main uses||Adrenal insufficiency, high blood calcium, autoimmune diseases, COPD, allergic reactions, tuberculosis|
|Side effects||Osteoporosis, cataracts, weakness, thrush|
|Typical dose||25 to 300 mg/day|
|Chemical and physical data|
|Molar mass||402.487 g·mol−1|
|3D model (JSmol)|
Cortisone acetate, sold under various brand names, is a corticosteroid used for a number of conditions. Some of these include adrenal insufficiency, high blood calcium, autoimmune diseases, COPD, allergic reactions, and certain types of tuberculosis. It is taken by mouth. Effects generally last for 1 to 2 days.
Commonly long term use results in osteoporosis, cataracts, weakness, and thrush. Other side effects may include infection, adrenal insufficiency, swelling, and poor wound healing. While short term use in the later part of pregnancy is safe, long term use may result in harm to the baby. It is a manufactured steroid with both glucocorticoid and mineralocorticoid properties.
Cortisone acetate was approved for medical use in the United States in 1950. It is available as a generic medication. In the United States 90 pills of 25 mg costs about 110 USD as of 2022. It is marketed in many countries globally.
A cortisone injection may provide short-term pain relief and may reduce the swelling from inflammation of a joint, tendon, or bursa in, for example, the joints of the knee, elbow and shoulder and into a broken coccyx.
The typical dose in adults is 25 to 300 mg per day.
Oral use of cortisone has a number of potential systemic adverse effects, including asthma, hyperglycemia, insulin resistance, diabetes mellitus, osteoporosis, anxiety, depression, amenorrhoea, cataracts, glaucoma, Cushing's syndrome, increased risk of infections and impaired growth. With topical application, it can lead to thinning of the skin, impaired wound healing, increased skin pigmentation, tendon rupture and skin infections (including abscesses).
Mechanism of action
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