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AliasesFGF3, HBGF-3, INT2, fibroblast growth factor 3
External IDsOMIM: 164950 MGI: 95517 HomoloGene: 3841 GeneCards: FGF3
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 11: 69.81 – 69.82 MbChr 7: 144.39 – 144.4 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.[5]


FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.[5]

Clinical significance

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.[5] Also, haploinsufficiency in the FGF3 gene is thought to cause otodental syndrome.


FGF3 (gene) has been shown to interact with EBNA1BP2.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186895 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031074 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "Entrez Gene: FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)".
  6. ^ Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (Aug 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC 87226. PMID 11438656.

Further reading