INSL3

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INSL3
Protein INSL3 PDB 2h8b.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesINSL3, RLF, RLNL, ley-I-L, insulin like 3
External IDsOMIM: 146738 MGI: 108427 HomoloGene: 4048 GeneCards: INSL3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005543
NM_001265587

NM_013564

RefSeq (protein)

NP_001252516
NP_005534

NP_038592

Location (UCSC)Chr 19: 17.82 – 17.82 MbChr 8: 72.14 – 72.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Insulin-like 3 is a protein that in humans is encoded by the INSL3 gene.[5][6]

Function

The protein encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. INSL-3 initiates meiotic progression in follicle-enclosed oocytes by mediating a reduction in intra-oocyte cAMP concentration by activating G protein-coupled receptor 8 (LGR8).[7] It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000248099 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079019 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Burkhardt E, Adham IM, Brosig B, Gastmann A, Mattei MG, Engel W (March 1994). "Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3)". Genomics. 20 (1): 13–9. doi:10.1006/geno.1994.1121. PMID 8020942.
  6. ^ a b "Entrez Gene: INSL3 insulin-like 3 (Leydig cell)".
  7. ^ Richard FJ (March 2007). "Regulation of meiotic maturation". Journal of Animal Science. 85 (13 Suppl): E4-6. doi:10.2527/jas.2006-475. PMID 17040950.

Further reading