|Other names||5,7,8-Trihydroxyflavone; 5,7,8-THF|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||270.240 g·mol−1|
|3D model (JSmol)|
Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in Scutellaria baicalensis (Baikal skullcap). It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin (7,8-DHF).
- Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell PE, et al. (2013). Khan AU (ed.). "Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii". PLOS ONE. 8 (4): e61594. Bibcode:2013PLoSO...861594M. doi:10.1371/journal.pone.0061594. PMC 3632535. PMID 23630600.
- Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. (December 2010). "A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect". Journal of Medicinal Chemistry. 53 (23): 8274–86. doi:10.1021/jm101206p. PMC 3150605. PMID 21073191.