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fibroblast growth factor 16
NCBI gene8823
Other data
LocusChr. X q21.1
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Fibroblast growth factor 16 is a protein which in humans is encoded by the FGF16 gene.[1][2]


The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The rat homolog is predominantly expressed in embryonic brown adipose tissue and has significant mitogenic activity, which suggests a role in proliferation of embryonic brown adipose tissue.[3]

Mutations in this gene have been found associated to cases of X-linked recessive metacarpal 4/5 fusion.[4]


  1. ^ Miyake A, Konishi M, Martin FH, Hernday NA, Ozaki K, Yamamoto S, Mikami T, Arakawa T, Itoh N (February 1998). "Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family". Biochemical and Biophysical Research Communications. 243 (1): 148–52. doi:10.1006/bbrc.1998.8073. PMID 9473496.
  2. ^ Kim HS (2001). "The human FGF gene family: chromosome location and phylogenetic analysis". Cytogenetics and Cell Genetics. 93 (1–2): 131–2. doi:10.1159/000056965. PMID 11474196. S2CID 20876318.
  3. ^ "Entrez Gene: Fibroblast growth factor 16".
  4. ^ Jamsheer A, Zemojtel T, Kolanczyk M, Stricker S, Hecht J, Krawitz P, Doelken SC, Glazar R, Socha M, Mundlos S (September 2013). "Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion". Journal of Medical Genetics. 50 (9): 579–84. doi:10.1136/jmedgenet-2013-101659. PMID 23709756. S2CID 9501794.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.