INSL4

From WikiProjectMed
Jump to navigation Jump to search
INSL4
Identifiers
AliasesINSL4, EPIL, PLACENTIN, insulin like 4
External IDsOMIM: 600910 HomoloGene: 88662 GeneCards: INSL4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002195

n/a

RefSeq (protein)

NP_002186

n/a

Location (UCSC)Chr 9: 5.23 – 5.24 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Early placenta insulin-like peptide is a protein that in humans is encoded by the INSL4 gene.[3][4][5]

INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120211 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Chassin D, Laurent A, Janneau JL, Berger R, Bellet D (Aug 1996). "Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta". Genomics. 29 (2): 465–70. doi:10.1006/geno.1995.9980. PMID 8666396.
  4. ^ Veitia R, Laurent A, Quintana-Murci L, Ottolenghi C, Fellous M, Vidaud M, McElreavey K (Oct 1998). "The INSL4 gene maps close to WI-5527 at 9p24.1→p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome". Cytogenet Cell Genet. 81 (3–4): 275–7. doi:10.1159/000015045. PMID 9730618. S2CID 46801238.
  5. ^ a b "Entrez Gene: INSL4 insulin-like 4 (placenta)".

Further reading