FGF14

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FGF14
Identifiers
AliasesFGF14, FGF-14, FHF-4, FHF4, SCA27, fibroblast growth factor 14
External IDsOMIM: 601515 MGI: 109189 HomoloGene: 3037 GeneCards: FGF14
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010201
NM_207667

RefSeq (protein)

NP_034331
NP_997550

Location (UCSC)Chr 13: 101.71 – 102.4 MbChr 14: 124.22 – 124.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fibroblast growth factor 14 is a biologically active protein that in humans is encoded by the FGF14 gene.[5][6][7]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.[7]

FGF14 is mainly expressed in the central nervous system and is associated with neurodegenerative diseases such as spinocerebellar ataxia (SAC27). FGF14 deficiency also impairs the maturation of cells in the hippocampus, which is possibly related to the development of schizophrenia.[8]

Relationship with Alzheimer's disease

FGF14 levels are elevated in patients with Alzheimer's disease. FGF14 messenger RNA was also found to be upregulated in Alzheimer's patients, which suggests that it is involved in the pathogenesis of the disease, although the underlying mechanism is still unknown. Research is ongoing as to whether or not FGF14 could be used as a therapy against Alzheimer's disease as well as other neurodegenerative diseases, by promote neural proliferation and regulating the plasticity of the synapses.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102466 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025551 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Oct 1996). "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A. 93 (18): 9850–7. Bibcode:1996PNAS...93.9850S. doi:10.1073/pnas.93.18.9850. PMC 38518. PMID 8790420.
  6. ^ Wozniak DF, Xiao M, Xu L, Yamada KA, Ornitz DM (Mar 2007). "Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14". Neurobiol Dis. 26 (1): 14–26. doi:10.1016/j.nbd.2006.11.014. PMC 2267915. PMID 17236779.
  7. ^ a b "Entrez Gene: FGF14 fibroblast growth factor 14".
  8. ^ Wang, Lusheng; Jing, Rongrong; Wang, Xing; Wang, Baohui; Guo, Keke; Zhao, Jungang; Gao, Shuang; Xu, Nuo; Xuan, Xuan (June 2021) [11 June 2021]. "A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer's disease model". Annals of Translational Medicine. 9 (12): 994. doi:10.21037/atm-21-2492. ISSN 2305-5839. PMC 8267273. PMID 34277794.

Further reading