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Available structures
PDBOrtholog search: PDBe RCSB
AliasesFGF18, FGF-18, ZFGF5, fibroblast growth factor 18
External IDsOMIM: 603726 MGI: 1277980 HomoloGene: 2867 GeneCards: FGF18
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 5: 171.42 – 171.46 MbChr 11: 33.07 – 33.1 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene.[5][6][7]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. FGF18 signals through fibroblast growth factor receptor FGFR3 to promote chondrogenesis[8] and has been shown to cause thickening of cartilage in a murine model of osteoarthritis,[9] and the recombinant version of it (sprifermin) is in clinical trial as a potential treatment for osteoarthritis.[10] Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156427 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057967 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fukui S, Itoh N (Aug 1998). "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18". J Biol Chem. 273 (29): 18161–4. doi:10.1074/jbc.273.29.18161. PMID 9660775.
  6. ^ Hu MC, Qiu WR, Wang YP, Hill D, Ring BD, Scully S, Bolon B, DeRose M, Luethy R, Simonet WS, Arakawa T, Danilenko DM (Nov 1998). "FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation". Mol Cell Biol. 18 (10): 6063–74. doi:10.1128/MCB.18.10.6063. PMC 109192. PMID 9742123.
  7. ^ a b "Entrez Gene: FGF18 fibroblast growth factor 18".
  8. ^ Davidson, D.; Blanc, A.; Filion, D.; Wang, H.; Plut, P.; Pfeffer, G.; Buschmann, M. D.; Henderson, J. E. (2005). "Fibroblast Growth Factor (FGF) 18 Signals through FGF Receptor 3 to Promote Chondrogenesis". Journal of Biological Chemistry. 280 (21): 20509–20515. doi:10.1074/jbc.M410148200. PMID 15781473.
  9. ^ Moore, E.; Bendele, A.; Thompson, D.; Littau, A.; Waggie, K.; Reardon, B.; Ellsworth, J. (2005). "Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis". Osteoarthritis and Cartilage. 13 (7): 623–631. doi:10.1016/j.joca.2005.03.003. PMID 15896984.
  10. ^ Merck Announces Collaboration With Nordic Bioscience for Sprifermin in Osteoarthritis of the Knee, retrieved 2013-04-02

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: O76093 (Fibroblast growth factor 18) at the PDBe-KB.