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Protein ANGPT2 PDB 1z3s.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesANGPT2, AGPT2, ANG2, angiopoietin 2, LMPHM10
External IDsOMIM: 601922 MGI: 1202890 HomoloGene: 22401 GeneCards: ANGPT2
RefSeq (mRNA)


RefSeq (protein)



Location (UCSC)Chr 8: 6.5 – 6.56 MbChr 8: 18.74 – 18.79 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.[5]

Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1[6]



ANGPT2 has been shown to interact with TEK tyrosine kinase.[7][8][9]

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091879 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031465 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cheung AH, Stewart RJ, Marsden PA (March 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics. 48 (3): 389–91. doi:10.1006/geno.1997.5207. PMID 9545648.
  6. ^ "Entrez Gene: ANGPT2 angiopoietin 2".
  7. ^ Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marmé D, Augustin HG (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". The Journal of Biological Chemistry. 278 (3): 1721–7. doi:10.1074/jbc.M208550200. PMID 12427764.
  8. ^ Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". International Immunology. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.
  9. ^ Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. doi:10.1126/science.277.5322.55. PMID 9204896.

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.